Effects of the Histamine H2 Receptor Antagonist Famotidine on the Healing of Colonic Anastomosis in Rats

Abstract

İnan A, Şen M, Sürgit O, Ergin M, Bozer M. Effects of the histamine h2 receptor antagonist famotidine on the healing of colonic anastomosis in rats. Clinics. 2009;64(6):567-70. BACKGROUND:Failure of anastomotic healing is one of the major complications in colorectal surgery. Because histamine plays an important role in immune and inflammatory reactions, we demonstrate the effects of famotidine on the healing of colonic anastomosis in rats. METHODS: Twenty-eight Sprague-Dawley rats were used in the study. Excision and end-to-end anastomosis was performed in the distal colon of the rat. The Famotidine Group received 2 mg/kg/day famotidine; the Control Group received the same amount of saline. Bursting pressure of anastomoses and hydroxyproline content of perianastomotic tissues were evaluated on the third and seventh days following surgery. RESULTS: Bursting pressures and hydroxyproline contents for the Famotidine Group were significantly lower than the equivalent parameters for the Control Group on both the third and seventh days post-surgery. CONCLUSIONS: According to our findings, famotidine exerts detrimental effects on the anastomotic bursting pressure and hydroxyproline content of perianastomotic tissues in the colon of rats.

İskemik kolon anastomozlarının iyileşmesi üzerine pentoxifylline ve vinpocetinenin etkisi. (Deneysel Çalışma)

“…Biochemical parameters of anastomotic healing are reflected by the collagen content in perianastomotic tissues, as determined by hydroxyproline content. [4] In this study, comparison of the control and treatment groups with regard to bursting pressure revealed a high, but not statistically significant, difference. Hydroxyproline levels were found to be higher in the treatment groups than in the control group.…”

“…[1,2] Anastomotic leak in colorectal surgery increases the morbidity and mortality rates. [3,4] Tissue blood flow and oxygenation are very significant factors contributing to the healing of colonic anastomosis, whereas ischemia and infection are known to be the most important factors interrupting the healing process. [5,6] Ischemia is one of the most influential causes leading to impaired wound healing.…”

“…Although the incidence of this complication has been significantly reduced with the application of modern surgical techniques, it is still an important complication. [4,9,[12][13][14] As with all anastomoses, tissue blood flow and oxygenation are considerable factors in colonic anastomoses. [5,12] In comparison with other gastrointestinal components, the colon is known to present higher anastomotic leak rates due to its certain anatomical and biological characteristics, such as low collagen content, high collagenase activity, reduced collateral circulation, and absence of a serosa in the extraperitoneal rectum.…”

“…The common denominator of all those studies was the effort to reduce ischemia. [4,5,12,14,16,17] Benacerraf et al [18] reported 100% anastomotic leak in cases where perianastomotic oxygen pressure was below 20 mmHg, while denoting that the anastomotic leak rate was reduced by elevation of oxygen pressure. In the current study, we used pentoxifylline and vinpocetine to reduce ischemia.…”

Effect of Ozone Therapy (OT) on Healing of Colonic Anastomosis in a Rat Model of Peritonitis

“…These agents include hyperbaric oxygen, glucan, erythropoietin, bosentan, growth hormone, and H 2 antagonists like famotidine. All of these agents aim to reduce ischemia (18)(19)(20)(21)(22)(23). OT increases tissue oxygenation by shifting the oxyhaemoglobin curve to the right.…”