2009
DOI: 10.1590/s1807-59322009000500012
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Abstract: INTRODUCTION: Mechanical ventilation with positive end expiratory pressure (PEEP) improves oxygenation and treats acute pulmonary failure. However, increased intrathoracic pressure may cause regional blood flow alterations that may contribute to mesenteric ischemia and gastrointestinal failure. We investigated the effects of different PEEP levels on mesenteric leukocyte-endothelial interactions. METHODS: Forty-four male Wistar rats were initially anesthetized (Pentobarb… Show more

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Cited by 12 publications
(14 citation statements)
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References 39 publications
(47 reference statements)
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“…ϭ 19). We continued anesthesia with isoflurane (1.5%) 26 during the 2 hours of mechanical ventilation, with a PEEP of 10 cm H 2 O on room air. The respiratory rate was set at 70 breaths/min in the high-V T and high-V T /pentoxifylline groups, and at 80 breaths/min in the low-V T group, to maintain normocapnia.…”
Section: Animalsmentioning
confidence: 99%
See 3 more Smart Citations
“…ϭ 19). We continued anesthesia with isoflurane (1.5%) 26 during the 2 hours of mechanical ventilation, with a PEEP of 10 cm H 2 O on room air. The respiratory rate was set at 70 breaths/min in the high-V T and high-V T /pentoxifylline groups, and at 80 breaths/min in the low-V T group, to maintain normocapnia.…”
Section: Animalsmentioning
confidence: 99%
“…[24][25][26] After midline abdominal incision, the distal ileum and its accompanying mesentery is exposed for examination of the microcirculation. The animal is placed in the right lateral decubitus on a warmed (37°C) stage, and the mesentery is transilluminated and kept moist with continuous applications of warm (37°C) Krebs solution.…”
Section: Intravital Microscopy Of the Mesenterymentioning
confidence: 99%
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“…(8) A randomized experimental study in rats, published by Aikawa et al, investigated the effects of different PEEP levels on mesenteric microcirculation and concluded that higher PEEP levels (≥ 10 cmH 2 O) cause impaired mesenteric flow. (9) …”
Section: Intensive Carementioning
confidence: 99%