2009
DOI: 10.1590/s1807-59322009000500009
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Abstract: INTRODUCTION: Invasive and non-invasive tests can be used to evaluate the activity of inflammatory bowel diseases. OBJECTIVE: The aim of the present study was to investigate the role of fecal calprotectin in evaluating inflammatory bowel disease activity and the correlation of fecal calprotectin with the erythrocyte sedimentation rate and C reactive protein values in inflammatory bowel disease. METHOD: Sixty-five patients affected with inflammatory bowel disease were enrolled. Twenty outpatients diagnosed with… Show more

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Cited by 45 publications
(40 citation statements)
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“…The association of FC with intestinal inflammatory diseases has been thoroughly investigated during the last decade [30]. It is believed that the presence of calprotectin in stool indicates increased neutrophil migration towards the intestinal mucosa, which is triggered by bowel inflammation [31]. Although the actual pathophysiologic pathways remain vague, it seems that the activated neutrophils gradually degranulate and secrete calprotectin, which inhibits matrix metalloproteinases and triggers apoptosis [32].…”
Section: Discussionmentioning
confidence: 99%
“…The association of FC with intestinal inflammatory diseases has been thoroughly investigated during the last decade [30]. It is believed that the presence of calprotectin in stool indicates increased neutrophil migration towards the intestinal mucosa, which is triggered by bowel inflammation [31]. Although the actual pathophysiologic pathways remain vague, it seems that the activated neutrophils gradually degranulate and secrete calprotectin, which inhibits matrix metalloproteinases and triggers apoptosis [32].…”
Section: Discussionmentioning
confidence: 99%
“…Some of the authors postulate that the correlation between fecal calprotectin concentration and the activity of the disease is stronger in the case of UC than in CD, which is linked with a rare involvement of the large intestine and with a lack of a complete mucosal healing even in remission phase [7,23,25]. Others have obtained similar fecal calprotectin concentration in both diseases [12,15,26,28] or directed attention to the strong correlation between the activity disease in patients with CD [13,29]. Kosiara and Komraus [14,27] have observed lower average concentration of fecal calprotectin in patients with CD; however, other authors have noted in patients in remission higher content of fecal calprotectin in patients with CD [12,20,26].…”
Section: Discussionmentioning
confidence: 99%
“…In Crohn's disease faecal calprotectin level will be usually elevated. [3][4][5] Patient not receiving BCG vaccination at his childhood could also be a contributing factor.…”
Section: Discussionmentioning
confidence: 99%