High Ratio of Triglycerides to HDL-Cholesterol Predicts Extensive Coronary Disease

Luz, Protásio Lemos da; Favarato, Desidério; Faria-Neto, José Rocha; Lemos, Pedro A.; Chagas, Antônio Carlos Palandri

doi:10.1590/s1807-59322008000400003

Cited by 253 publications

(101 citation statements)

References 21 publications

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“…Corresponding lipid ratios of triglycerides/HDL cholesterol and triglycerides/non-HDL cholesterol were increasing with an increase in FR index. Overall, these findings were in agreement with other study of similar nature [8]. These findings validate the high risk profile for obstructive coronary artery disease in patients with abnormal lipid levels, which makes this population appropriate for the analysis of the correlation between lipid profile and extent of impairment of the coronary arteries.…”

Section: Discussionsupporting

confidence: 91%

“…Several clinical and epidemiological studies have indicated a strong association between dyslipidemia and atherosclerosis [2]- [7]. Nevertheless, data on the association between lipid levels and extent or severity of coronary lesions in patients with coronary artery disease are limited [8]. Friesinger (FR) index [9] is an important tool to assess the extent and severity of coronary artery lesions.…”

Section: Introductionmentioning

confidence: 99%

“…Friesinger (FR) index [9] is an important tool to assess the extent and severity of coronary artery lesions. A significant association between the FR index and lipid levels has been observed in the past years [8]. However, such investigations are very scarce in literature.…”

Section: Introductionmentioning

confidence: 99%

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Link between Friesinger Index and Lipid Profile in Patients Undergoing Diagnostic Coronary Angiography

Agarwal¹,

Sinha²,

Jaiswal³

et al. 2015

IJCM

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Background: A strong association between abnormal lipid variables and development of atherosclerosis is widely established. However, few data exist on the association between lipid levels and the extent or severity of coronary lesions in patients with coronary artery disease. Objective: We aimed to determine the link between lipid levels and the extent or severity of coronary lesions in patients with suspected coronary artery disease using Friesinger index (FR). Methodology: In this prospective and singe-center study, consecutive patients who underwent coronary angiography for diagnostic purposes were analyzed. Each participant was evaluated for lipid levels i.e. total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, very-low-density lipoprotein (VLDL) cholesterol, non-HDL cholesterol, triglycerides/ HDL cholesterol, and triglycerides/non-HDL cholesterol. The extent of coronary disease was evaluated using FR index. Results: A total of 566 patients (mean age: 56.17 ± 9.99 years) were included in the study. The mean FR index was 5.40 ± 3.78. A significantly positive correlation was observed between FR index and total cholesterol (P = 0.002), triglycerides (P < 0.001), VLDL cholesterol (P < 0.001), non-HDL cholesterol (P = 0.006), triglycerides/HDL cholesterol ratio (P = 0.008), and triglycerides/non-HDL cholesterol ratio (P = 0.002). On the contrary, an inverse correlation was observed between FR index and HDL cholesterol (P < 0.001). Age or gender played no role in governing the FR index severity, while body-mass index, hypertension, diabetes, and smoking showed significant association with FR index (P < 0.001 for all). Conclusion: The present study demonstrates a significant link between the extent of coronary artery disease and levels of certain lipid variables.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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Link between Friesinger Index and Lipid Profile in Patients Undergoing Diagnostic Coronary Angiography

Agarwal¹,

Sinha²,

Jaiswal³

et al. 2015

IJCM

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“…Luz et al found Friesinger index 0 in 19.0% patients, 1-4 in 17.9% patients, 5 -10 in 36.1% patients and 11-15 in 27.0% patients. 26 There was a strong positive correlation between the QTc dispersion and Leaman score (Pearson's correlation coefficient). Bampi et al observed that, Friesinger score 0-4 indicates less extensive disease and Friesinger score e"5 indicates extensive coronary atherosclerosis with extensive coronary artery disease.…”

Section: Discussionmentioning

confidence: 96%

“…[25][26][27] Female are less prone to developed IHD in premenopausal age due to protective role of estrogen, moreover smoking as a risk factor of IHD is less common in our country among female, which may explain male predominance of IHD. 28 The common risk factors for coronary artery disease in the present study showed that, smoking was the highest in Group-I followed by hypertension, family history of CAD, diabetes mellitus (DM) and dyslipidemia.…”

Section: Prolonged Qtc Dispersion and Leaman Scorementioning

confidence: 99%

Prolonged QTc Dispersion Correlates with Coronary Artery Disease in Acute ST Elevated Myocardial Infarction (STEMI)

et al. 2013

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Background: It has been found that there is strong association of QT dispersion and QT dispersion ratio with extent and severity of coronary artery disease. Qualitative importance of QTc dispersion on the base line ECG in patients with MI is recognized clinically but quantification of this phenomenon is less commonly used in clinical practice, which might be a better independent risk predictor of this group of patients. Methods: A total of 100 patients were selected, Study populations sub-divided into two groups on the basis of QTc dispersion. In group I (comparison group): QTc dispersion is <60 milliseconds (msec) in group II (study group) : QTc dispersion e60milliseconds(msec). 50 patients in each group. QT dispersion was calculated on standard resting 12 lead ECGs. QT interval was measured from the beginning of the inscription of the QRS complex to the point at which the T wave returned to the isoelectric line. Angiographic severity of coronary artery disease was assessed by- Vessel score, Friesinger score and Leaman score. Interpretation of coronary angiogram was reviewed by at least two cardiologists. . Results: The mean vessel score for group I patients was 1.16±0.68 and that of group II patients was 2.30±0.64 and the mean difference was statistically significant (p<0.05). Patients those had single vessel involvement had mean QTc dispersion 57.05, patients those had double vessel disease mean QTc dispersion was 102.00 and patients those had triple vessel involvement had mean QTc dispersion 177.60. There was a strong positive correlation with the QTc dispersion and increasing number of vessel involvement (Pearsons correlation coefficient). The mean Friesinger score for group I patients was 4.84±2.56 and that of group II patients was 9.80±2.60. The mean difference was significantly (p<0.05) higher in group II patients. There was a strong positive correlation between the QTc dispersion and Leaman score (Pearsons correlation coefficient). In group I patients 56% had insignificant coronary artery disease and 44% had significant coronary artery disease defined by Friesinger index (n=100). In group II patients 6% had Insignificant coronary artery disease & had 94% significant coronary artery disease. Conclusion: QTc dispersion>60 ms had independent predictive value for the severity of coronary artery disease. The greater the QTc dispersion the higher the number of coronary artery involvement. We observed that there is a positive correlation between prolonged QT dispersion and coronary artery disease severity in terms of Vessel score, Friesinger score, Leaman score. DOI: http://dx.doi.org/10.3329/cardio.v5i2.14322 Cardiovasc. j. 2013; 5(2): 173-181

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Epidemiology

2011

High‐Density Lipoproteins

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High Ratio of Triglycerides to HDL-Cholesterol Predicts Extensive Coronary Disease

Cited by 253 publications

References 21 publications

Link between Friesinger Index and Lipid Profile in Patients Undergoing Diagnostic Coronary Angiography

Link between Friesinger Index and Lipid Profile in Patients Undergoing Diagnostic Coronary Angiography

Prolonged QTc Dispersion Correlates with Coronary Artery Disease in Acute ST Elevated Myocardial Infarction (STEMI)

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