2008
DOI: 10.1590/s1807-59322008000100019
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Sepsis is a syndrome related to severe infections. It is defined as the systemic host response to microorganisms in previously sterile tissues and is characterized by end-organ dysfunction away from the primary site of infection. The normal host response to infection is complex and aims to identify and control pathogen invasion, as well as to start immediate tissue repair. Both the cellular and humoral immune systems are activated, giving rise to both anti-inflammatory and proinflammatory responses. The chain … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
18
0
5

Year Published

2010
2010
2022
2022

Publication Types

Select...
6
2
1

Relationship

0
9

Authors

Journals

citations
Cited by 30 publications
(24 citation statements)
references
References 110 publications
(118 reference statements)
1
18
0
5
Order By: Relevance
“…It is appraised that in the United States more than 750,000 septic cases occur once a year and even with optimal treatment, mortality is approximately 40 percent and can exceed 50 percent in some critically ill patients with worse clinical status (18)(19)(20)(21). Until the present time, no worldwide approved pharmacologic agents for the treatment or prevention of sepsis are present.…”
Section: Discussionmentioning
confidence: 99%
“…It is appraised that in the United States more than 750,000 septic cases occur once a year and even with optimal treatment, mortality is approximately 40 percent and can exceed 50 percent in some critically ill patients with worse clinical status (18)(19)(20)(21). Until the present time, no worldwide approved pharmacologic agents for the treatment or prevention of sepsis are present.…”
Section: Discussionmentioning
confidence: 99%
“…The annual health care expenditure associated with this ailment is as high as $16.7 billion per year in the United States. [1] Previous studies [2,3] on the pathogenesis of sepsis has highlighted the importance of proinflammatory mediators in the course of sepsis. Despite success in animals, clinical trials aiming at inhibiting the early cytokine mediators[i. e., tumor necrosis factor (TNF) or interleukin (IL) -1] have failed to improve survival in septic patients.…”
Section: Introductionmentioning
confidence: 99%
“…Böylece çok düşük yoğunluklu lipoprotein (very low density lipoprotein; ÇDYL)'lerin yıkımı hızlanmakta ve plazma YYL düzeyleri yükselmektedir. Fibrik asit türevleri (fibratlar) YYL düzeylerini artırırken, trigliserit düzeylerini azaltır-lar (32)(33)(34)(35)(36). Bu etkiler PPARα aracılı mekanizmalarla gerçekleşmektedir.…”
Section: Ppar Alt Türlerinin İnsülin Direnci Patojenezindeki Rolüunclassified