Adenosquamous Carcinoma of the Penis

Romero, Frederico R.; Castro, Marí­lia Germanos de; Garcia, Carlos Ricardo Camargo; Perez, Marcelo Vaz

doi:10.1590/s1807-59322006000400016

Cited by 15 publications

(4 citation statements)

References 9 publications

(19 reference statements)

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“…59 There is little knowledge about nonurethral glandular tumors of the penis, 60 but the potential of the surface squamous epithelium of the penis to differentiate along glandular lines was proven in this study by the identification in both series of adenosquamous carcinomas. 61,62 Similar to other subtypes, we found no differences in their incidence.…”

Section: Discussionsupporting

confidence: 72%

Comparison of Subtypes of Penile Squamous Cell Carcinoma From High and Low Incidence Geographical Regions

Chaux¹,

Lezcano²,

Cubilla³

et al. 2009

Int J Surg Pathol

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There is a worldwide geographical variation in the incidence of penile squamous cell carcinoma (PSCC); some subtypes are HPV-related (warty, basaloid) while others (keratinizing variants) are not. The aims of this study were to compare the distribution of different histological subtypes of PSCC from regions of low (Paraguay, 144 cases) and high (USA, 157 cases) incidence and to identify and compare tumors with and without warty and/or basaloid morphology. The distribution of subtypes in the Paraguayan and the American series was: usual, 49.3 and 46.5%; verrucous, 8.3 and 7.6%; papillary NOS, 7.6 and 5.7%; warty, 6.9 and 8.3%; basaloid, 4.2 and 7.0%; sarcomatoid, 0.7 and 0.6%; adenosquamous, 3.5 and 0.6%; and mixed, 19.4 and 23.6%, respectively. The distribution of mixed PSCC was: warty-basaloid, 50.0 and 59.5%; usual-verrucous, 21.4 and 21.6%; usual-warty, 14.3 and 8.1%; usual-basaloid, 7.1 and 0.0%; usual-papillary, 3.6 and 5.4%; and others, 3.6 and 5.4%, respectively. In conclusion, we found no geographical difference in the incidence of histological subtypes (p = 0.6501), mixed PSCC (p = 0.5937) or HPV-related tumors (p = 0.2505). Geographical variation may be the result of staging variation at clinical presentation or of pathological diagnosis. The identification of similar histological subtypes in both series validates this classification approach for penile cancer. The tendency for typical SCC to mix with verrucous and papillary carcinomas and of the basaloid to preferentially mix with benign condyloma and condylomatous (warty) carcinomas would support the hypothesis of the existence of an etiologically different dual population of penile tumors.

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Section: Discussionsupporting

confidence: 72%

Comparison of Subtypes of Penile Squamous Cell Carcinoma From High and Low Incidence Geographical Regions

Chaux¹,

Lezcano²,

Cubilla³

et al. 2009

Int J Surg Pathol

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“…About a dozen cases have been reported [16,[29][30][31][32][33][34]. The tumor originates in the glans central/perimeatal region and has a tendency for deep infiltration.…”

Section: Variegated Spectrum Of Penile Squamous Cell Carcinomasmentioning

confidence: 99%

Advances in the pathology of penile carcinomas

Chaux

Cubilla²

2012

Human Pathology

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“…Primary cutaneous ASC often has an aggressive course with a propensity for both local recurrence and distant metastasis. We have identified 12 cases of ASC of the penis, none of which had their HPV states reported to our knowledge . Given the spectrum of histologic presentations of SCC of the penis the presence of oncogenic virus within this uncommon tumor type is intriguing.…”

Section: Discussionmentioning

confidence: 99%

“…Pseudoglandular SCC demonstrates a cracked appearance similar to gland formation; however, upon close inspection, no mucin production is seen and the gland‐like areas are found to be acantholytic squamous cells forming cleft‐like spaces with discohesive cells that appear to ‘float’ in these spaces . In addition to the difference in histologic appearance, these tumors do not show immunohistochemical expression for carcinoembryonic antigen (CEA) …”

Section: Discussionmentioning

confidence: 99%

Primary cutaneous adenosquamous carcinoma of the penis: the first characterization of HPV status in this rare and diagnostically challenging entity with review of glandular carcinomas of the penis

et al. 2016

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Glandular and pseudoglandular tumors of the penile skin are extremely uncommon and can present diagnostic challenges. Primary adenosquamous carcinoma of the penis is an extremely rare tumor, composed of distinct areas of malignant squamous and glandular cells, making it a diagnostically challenging entity. The World Health Organization (WHO) recognizes several subtypes of squamous cell carcinoma (SCC), each with its own distinctive pathologic appearance, clinical associations and prognosis. Among these variants is the exceedingly uncommon adenosquamous carcinoma (ASC), representing 1%-2% of all SCC of the penis. Recent large studies have interrogated the presence of human papillomavirus (HPV) in malignant penile tumors and have shown specific morphologic patterns and clinical presentations to associate with HPV status. However, given the rarity of the adenosquamous variant of SCC, it has largely been excluded from these studies. The glandular components of these lesions can present a confusing appearance, particularly when a large tumor is represented on a small biopsy. Here we describe a difficult histologic presentation of this rare tumor, with the first published characterization of the HPV status of this subtype. This case represents a distinctly unusual case of metastatic HPV-positive primary cutaneous adenosquamous carcinoma of the penis.

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Adenosquamous Carcinoma of the Penis

Cited by 15 publications

References 9 publications

Comparison of Subtypes of Penile Squamous Cell Carcinoma From High and Low Incidence Geographical Regions

Comparison of Subtypes of Penile Squamous Cell Carcinoma From High and Low Incidence Geographical Regions

Advances in the pathology of penile carcinomas

Primary cutaneous adenosquamous carcinoma of the penis: the first characterization of HPV status in this rare and diagnostically challenging entity with review of glandular carcinomas of the penis

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