2005
DOI: 10.1590/s1807-59322005000400010
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Abstract: PURPOSE: To determine whether patients with male factor infertility can be accurately identified by calculating a novel semen quality score and measuring levels of reactive oxygen species during routine infertility screening. METHODS: Semen samples from 133 patients and 91 healthy donors were evaluated with manual and computer-assisted semen analysis. A principal component analysis model was employed to calculate a semen quality score. In brief, this score was calculated by base 10 logarithms multiplied by var… Show more

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Cited by 16 publications
(12 citation statements)
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References 36 publications
(38 reference statements)
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“…Such long exposure of oocytes to spermatozoa can increase oxygen species-induced damage (27,28), and therefore, some laboratories have considered shortening this time. Reports show the beneficial effects of short coincubation of gametes in IVF (29)(30)(31), whereas other investigators noted the opposite (32,33).…”
Section: Discussionmentioning
confidence: 99%
“…Such long exposure of oocytes to spermatozoa can increase oxygen species-induced damage (27,28), and therefore, some laboratories have considered shortening this time. Reports show the beneficial effects of short coincubation of gametes in IVF (29)(30)(31), whereas other investigators noted the opposite (32,33).…”
Section: Discussionmentioning
confidence: 99%
“…In Drosophila, lack of Cu-Zn SOD also causes nearly complete sterility in males (12). A growing body of evidence associates ROS in humans with reduced sperm vitality (13), ovarian DNA damage (14), and preeclampsia and other pregnancy complications (15). Surprisingly, mice in which the catalase gene is disrupted grow normally and are as fertile as wild-type mice (16), indicating that, in vertebrates, this enzyme is not essential to protect spermatozoids or the ovaries from oxidative damage.…”
Section: •ϫmentioning
confidence: 99%
“…Reports from our center have shown that measurement of ROS level should be included in routine semen analysis (2,7,8). Previously, we have reported that ROS cutoff value of 0.0185 Â 10 6 cpm/20 Â 10 6 sperm is highly predictive of infertility (2).…”
mentioning
confidence: 99%