2010
DOI: 10.1590/s1806-83242010000200010
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Abstract: Cyclosporin A (CyA) induces gingival overgrowth via its stimulatory effects on expression of transforming growth factor-beta1 (TGF-β1) and collagen. It is not known whether CyA has a direct effect on gingival fibroblasts or induces its effect indirectly via stimulation of myofibroblast transdifferentiation. The present study was undertaken to examine the in vivo and in vitro effect of CyA on myofibroblast transdifferentiation. Rats were treated for 60 days with a daily subcutaneous injection of CyA, and the gi… Show more

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Cited by 11 publications
(9 citation statements)
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“…We found that treatment of HDF with TGFβ1 caused formation of actin-containing stress fibers, in a fashion sensitive to DPI and NAC ( Fig 3 ). TGFβ1 caused an appreciable increase in rhodamine-phalloidin signal in HGF; however, consistent with previous observations [ 20 22 ], actin-containing stress fibers were not readily apparent. Nonetheless, this modest increase in rhodamine-phalloidin signal was sensitive to NAC and DPI ( Fig 3 ).…”
Section: Resultssupporting
confidence: 91%
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“…We found that treatment of HDF with TGFβ1 caused formation of actin-containing stress fibers, in a fashion sensitive to DPI and NAC ( Fig 3 ). TGFβ1 caused an appreciable increase in rhodamine-phalloidin signal in HGF; however, consistent with previous observations [ 20 22 ], actin-containing stress fibers were not readily apparent. Nonetheless, this modest increase in rhodamine-phalloidin signal was sensitive to NAC and DPI ( Fig 3 ).…”
Section: Resultssupporting
confidence: 91%
“…Pathological scarring is caused by the myofibroblast, a type of fibroblast containing contractile α-SMA stress fibers [ 3 , 18 ]. Fibrotic responses in the oral cavity are hyperproliferative, resulting in gingival overgrowths instead of scar tissue that possess abundant myofibroblasts [ 4 , 20 22 ]. In every model thus far examined, CCN2 expression is an excellent surrogate marker for the severity of fibrosis [ 25 ].…”
Section: Discussionmentioning
confidence: 99%
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“…Although immunohistochemical studies did not reveal the presence of MFs [13,18], cell cultures of fibroblasts from healthy gingiva and periodontal ligament demonstrated that a few cells express alpha-SMA [19,23]. It remains to be determined whether the alpha-SMA positive cells in gingiva and periodontal ligament represent a permanent or modulated fibroblastic population.…”
Section: Discussionmentioning
confidence: 99%
“…These lesions are characterized by a diverse array of responses with a more fibrotic reaction in phenytoin-derived lesions, higher inflammation and less fibrosis in cyclosporine A lesions and a mixed condition in nifedipine-derived lesions (Uzel et al, 2001). This heterogeneity is probably reflected in the involvement of myofibroblasts in these lesions as this cell phenotype has been identified in phenytoin-induced gingival overgrowth (Dill & Iacopino, 1997) but not in cyclosporine A-induced lesions (Sobral, Kellermann, Graner, Martelli-Junior, & Coletta, 2010). It is highly probable that the heterogenic nature of the connective cell populations in the periodontium (Häkkinen & Larjava, 1992;McCulloch & Bordin, 1991), as well as the diverse array of factors that may stimulate these responses, may explain these apparently discrepant results.…”
Section: Myofibroblasts and Their Role In Drug-induced Gingival Ovementioning
confidence: 99%