Staphylococcal superantigen-specific IgE antibodies: degree of sensitization and association with severity of asthma

Filho, Elabras J; Fc, Mello; Lupi, Omar; Be, Bica; Ja, Papi; At, França

doi:10.1590/s1806-37562016000000010

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…A number of studies have demonstrated in the past that sensitization to staphylococcal enterotoxins is associated with asthma severity ( 16 – 19 ), asthma exacerbations ( 17 ), asthma control and age of asthma onset ( 20 , 21 ). There is only one study that associates increased SE-IgE to COPD exacerbations and COPD control but without defining the allergic profile of those COPD patients ( 22 ) ( Table 1 ).…”

Section: Interplay Between Atopy and Bacterial Infection In Asthma And Copdmentioning

confidence: 99%

The Role of Atopy in COPD and Asthma

et al. 2021

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Common to several allergic diseases is the generation of immunoglobulin E (IgE) by plasma cells, when exposed to an innocuous antigen. Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent chronic airway inflammatory diseases. Asthma is mediated in some patients through eosinophilic inflammatory mechanisms that include allergic sensitization and Th2-mediated immune airway response. COPD, on the other hand is mainly considered a Th1-mediated inflammatory process with neutrophilic predominance or a non-Th2 inflammation, occasionally associated with the presence of airway bacteria or viruses. IgE production appears to play an important role in the development of both COPD and asthma, as it has been associated to respiratory symptoms, lung function, bacterial and viral infections, airway remodeling and bronchial hyperreactivity in both diseases. The aim of this review is to summarize all current data concerning the role of specific and total IgE in COPD and asthma and to highlight similarities and differences in view of possible therapeutic interventions.

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Section: Interplay Between Atopy and Bacterial Infection In Asthma And Copdmentioning

confidence: 99%

The Role of Atopy in COPD and Asthma

et al. 2021

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“…Clinical improvement was more noticeable in NCSA-positive patients than NCSA-negative for nasal symptoms (35.2% vs. 21%) but comparable to each other for nonnasal symptoms (15.7% vs. 15.2%), however, the difference is non-significant. The symptom severity scores in the two groups after finishing the course of immunotherapy is shown in table (5).…”

Section: Egyptian Journal Of Medical Microbiologymentioning

confidence: 99%

“…Staphylococcal toxins, which have a superantigenic activity, act locally by stimulating polyclonal T cell and B cell proliferation and causing class switching to immunoglobulin IgE leading to production of allergen-specific IgE by mucosal B cells 4 . Serum IgE antibodies to staphylococcal superantigens are also produced 5 . Moreover, S. aureus superantigens inhibit the activity of T regulatory cells that normally control inflammation 4 .…”

Section: Introductionmentioning

confidence: 99%

Nasal Carriage of Staphylococcus aureus does not affect the Clinical Response to Immunotherapy in Allergic Rhinitis Patients

Elazab

2018

Egyptian Journal of Medical Microbiology

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Nasal carriage of Staphylococcus aureus (NCSA) is frequent in patients with allergic rhinitis (AR). Allergen immunotherapy is safe and effective in the treatment of AR. Objective: The present work aims to assess the effect of NCSA on the clinical response to immunotherapy (IT) in AR patients. Methodology: Assessment of symptom severity was done by visual analogue scale in 25 NCSA-positive and 25 NCSA-negative AR patients. Patients were treated by cluster IT for 8 weeks after which symptom severity was reassessed. Results: Before IT, NCSA-positive patients showed significant increase in rhinorrhea, sneezing, and nasal blockage than NCSA-negative patients. No significant difference was observed in non-nasal symptoms or total symptom severity scores. After IT, there was no difference in the severity of nasal and non-nasal symptoms between the two groups. Clinical improvement was more noticeable in NCSA-positive than NCSAnegative patients; however, the difference is non-significant. Conclusion: NCSA does not affect the clinical response to immunotherapy in AR patients.

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Role of Superantigens in Allergic Inflammation: Their Relationship to Allergic Rhinitis, Chronic Rhinosinusitis, Asthma, and Atopic Dermatitis

Muluk

Altın

Cingi

2018

Am J Rhinol�Allergy

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Objectives Our intention was to review all material published to date regarding superantigens (SAgs) and allergy from an otorhinolaryngological viewpoint to understand this association more clearly. Methods We identified all materials published mentioning both SAg and allergic rhinitis (AR), chronic sinusitis, asthma, and atopic dermatitis (AD) that are indexed on PubMed, Google, or the ProQuest Central databases. Results Staphylococcus aureus is a significant bacterial pathogen in humans and has the ability to produce enterotoxins with superantigenic features. The inflammatory response in allergy seen in both B cell and T cell may be attributed to SAgs. Sufferers of both allergic asthma with rhinitis and AR alone produce serological evidence of immunoglobulin E formation to SAgs produced by S. aureus. Perennial AR sufferers carry S. aureus more frequently and the presence of the organism within the nasal cavity may exacerbate perennial AR. SAg produced by S. aureus potentially worsens the asthmatic inflammatory response within the airway and may lead to the airways becoming hyperresponsive, as well as possibly activating T cells if asthmatic control is poor. Staphylococcal SAgs potentially increase the risk of developing chronic rhinosinusitis with nasal polyposis, additionally being a marker for more severe disease. If SAgs bring about chronic inflammatory responses in the nose and sinuses, then T cells excreting interferon-gamma may be a crucial mediator. In allergic dermatitis, S. aureus could be a key player in exacerbation of the condition. Even in younger pediatric patients with allergic dermatitis, allergic hypersensitivity to SAgs is frequent and may be a factor explaining how severe the condition becomes. Conclusion Just as SAgs are known to feature in many allergic conditions, they play their part in AR, chronic rhinosinusitis, asthma, and AD. Further research is required before the relationship between SAgs and allergy can be adequately explained.

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Staphylococcal superantigen-specific IgE antibodies: degree of sensitization and association with severity of asthma

Cited by 4 publications

References 17 publications

The Role of Atopy in COPD and Asthma

The Role of Atopy in COPD and Asthma

Nasal Carriage of Staphylococcus aureus does not affect the Clinical Response to Immunotherapy in Allergic Rhinitis Patients

Role of Superantigens in Allergic Inflammation: Their Relationship to Allergic Rhinitis, Chronic Rhinosinusitis, Asthma, and Atopic Dermatitis

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