2009
DOI: 10.1590/s1806-37132009001100011
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Abstract: It has been well established that, in addition to the pulmonary involvement, COPD has systemic consequences that can lead to peripheral muscle dysfunction, with greater muscle fatigue, lower exercise tolerance and lower survival in these patients. In view of the negative repercussions of early muscle fatigue in COPD, the objective of this review was to discuss the principal findings in the literature on the metabolic and bioenergy determinants of muscle fatigue, its functional repercussions, as well as the met… Show more

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Cited by 31 publications
(17 citation statements)
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“…Sarcopenia is an important public health concern due to its role in exercise intolerance, increased morbidity, and loss of independence in the elderly [105-108]. This loss of independence is due to an inability to perform activities of daily living that require sustained muscle power, such as walking, dressing, and showering as well as an increased risk of falling [109].…”
Section: Reviewmentioning
confidence: 99%
“…Sarcopenia is an important public health concern due to its role in exercise intolerance, increased morbidity, and loss of independence in the elderly [105-108]. This loss of independence is due to an inability to perform activities of daily living that require sustained muscle power, such as walking, dressing, and showering as well as an increased risk of falling [109].…”
Section: Reviewmentioning
confidence: 99%
“…Fatigue in response to exercise (exercise (-induced) fatigue) can be caused by mental disorders, organic central nervous system (CNS) abnormalities (central fatigue), or by peripheral nervous system (PNS) dysfunction or skeletal muscle disease (peripheral, muscle, contractile, or mechanical fatigue, contractile impairment, loss of force generating capacity) [1,2]. Factors that contribute to feeling tired include neurological and non-neurological causes [3].…”
Section: Introductionmentioning
confidence: 99%
“…Skeletal muscle dysfunction (reduced muscle strength and endurance and increased muscle fatigability) is a central contributor to the limitations in exercise capacity seen in patients with COPD,42 but there have been few comparisons of skeletal muscle dysfunction in men and women. Higher muscle fatigue in COPD patients may be due to lower levels of high-energy phosphates, lower mitochondrial density, early lactacidemia, or reduced muscle perfusion 43. However, in men and women with COPD with similar exercise capacity, no differences have been found in fiber type composition, mitochondrial density, and muscle enzyme activities in the quadriceps femoris muscle 44.…”
Section: Discussionmentioning
confidence: 98%