2008
DOI: 10.1590/s1806-37132008000700004
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Abstract: Objective: The aim of this study was to identify the best experimental model in which to observe the pulmonary alterations characterizing hepatopulmonary syndrome (HPS). Methods: Male Wistar rats, with mean weight of 250 g, were used in four experimental models: inhaled carbon tetrachloride; intraperitoneal carbon tetrachloride; partial portal vein ligation; and bile duct ligation (BDL). The animals in all groups were divided into control and experimental subgroups. The following variables were measured: trans… Show more

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Cited by 7 publications
(11 citation statements)
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“…Regarding photomicrographs of the lung tissue, the BDL model caused an increase in diameter of arterioles of the lung tissue. This finding corroborates studies reporting the increase of animals subjected to BDL (29) . This result may be due to the increased intrapulmonary shunt caused by liver injury leading to an accumulation of blood in the body, which in turn dilates the arterioles of the lung tissue and releases nitric oxide.…”
Section: Discussionsupporting
confidence: 92%
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“…Regarding photomicrographs of the lung tissue, the BDL model caused an increase in diameter of arterioles of the lung tissue. This finding corroborates studies reporting the increase of animals subjected to BDL (29) . This result may be due to the increased intrapulmonary shunt caused by liver injury leading to an accumulation of blood in the body, which in turn dilates the arterioles of the lung tissue and releases nitric oxide.…”
Section: Discussionsupporting
confidence: 92%
“…Studies by Kontouras et al (14) showed that 15 days after bile duct ligation (BDL), the metabolic and biochemical changes were not fully established. Thus, in our experiment, the animals were sacrificed only after 28 days of BDL, when studies confirmed liver cirrhosis (17,29) . In this study, both the BDL and the CCl 4 caused liver damage and elevated serum levels of AST, ALT and ALP, which are commonly known to be markers of liver injury.…”
Section: Discussionmentioning
confidence: 99%
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“…(1-5, [8][9][10][11][12][13][14][15] As características fisiopatológicas da SHP experimental induzida pela ligadura do ducto biliar comum (ligadura do colédoco) são alterações da microvasculatura pulmonar, incluindo vasodilatação, acúmulo intravascular de monócitos e a angiogênese. Alguns autores mostraram um aumento na expressão da enzima óxido nítrico sintase induzível (iNOS) nos pulmões dos animais com ligadura do colédoco e que pode também contribuir para a produção de ON local durante a progressão da SHP.…”
Section: Descriptorsunclassified
“…(11,14,(16)(17)(18)(19)(20)(21)(22) Este modelo simula a doença devido às alterações decorrentes da reação inflamatória causada pela estase biliar, e a desorganização da arquitetura natural do parênquima, com áreas inflamatórias e da deposição de colágeno e fibrose. (9)(10)(11) Com a demonstração prévia por alguns autores como Fallon et al,…”
Section: Descriptorsunclassified