Pleurodese: técnica e indicações

Vaz, Marcelo C.; Marchi, Evaldo; Vargas, Francisco Suso

doi:10.1590/s1806-37132006000400014

Cited by 10 publications

(2 citation statements)

References 17 publications

(19 reference statements)

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“…[1] In addition to dyspnea, recurrent thoracenteses often deteriorate the general condition of the patients who are in the terminal period by disrupting the protein, electrolyte, and fluid balance. [2][3][4] Pleurodesis is the process of eliminating pleural space to prevent the recurrence of pleural effusion or pneumothorax. Owing to its success in palliative treatment, patients with malignant pleural effusion (MPE) are the most frequently used.…”

Section: Introductionmentioning

confidence: 99%

Evaluation Of Quality Of Life In Patients With Pleurodesis

Ersöz¹

2019

South Clin Ist Euras

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Malignant pleural effusions (MPEs) cause a decrease in the quality of life and are the most important cause of anxiety in this group of patients. Currently, it is aimed not only to eliminate the diseases but also to increase the quality of life of individuals. The aim of the present study was to determine the effect of pleurodesis on the quality of life of patients with MPE. Methods: Twenty-four patients who underwent pleurodesis were prospectively included in the study. Talc pleurodesis was performed to the patients by tube thoracostomy. The 36-Item Short Form Survey (SF-36) quality of life scale was applied to the patients during their hospitalization and on day 11 of discharge. Data were analyzed statistically. Results: Female patients comprised 70.8% (n=17) of the cases. The mean age of the patients was 54.29±13.84 years. Fifty percent (n=12) of the cases were applied pleurodesis due to pleura metastasis of breast cancer, whereas 29.2% (n=7) due to lung cancer and the rest (20.8%, n=5) due to ovarian carcinomas, respectively. As a result of the comparison of the responses of the patients to the SF-36 quality of life results before and after the procedure, pleurodesis provided significantly positive results on all parameters (p<0.05) except for only mental health (p=0.20). Conclusion: The main reason for impairment in mental health is that patients have advanced cancers. We believe that the explanation of that is if pleurodesis does not change the stage of cancer. However, the presence of significant contribution of the treatment on all of the other parameters is an indication of how important pleurodesis is. Our study also provided hints that young patients can benefit more from pleurodesis. We think that the patient's cachexia status due to primary disease has no effect on the quality of life that pleurodesis provided. We believe that pleurodesis should be performed in all patients with MPE, if possible.

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Section: Introductionmentioning

confidence: 99%

Evaluation Of Quality Of Life In Patients With Pleurodesis

Ersöz¹

2019

South Clin Ist Euras

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“…O processo inflamatório pleural induzido pela injeção de um agente esclerosante no espaço pleural não está completamente elucidado e é dependente do esclerosante escolhido [5] . É referido que na fase precoce da pleurodese induzida por talco ou nitrato de prata ocorre inflamação aguda pleural e sistêmica com recrutamento de neutrófilos e liberação de citocinas inflamatórias tais como IL-8 e VEGF [6] , A interleucina 8 é um potente fator quimiotático que parece ter grande importância na formação do derrame pleural.…”

Section: Conclusãounclassified

Influência do anticorpo anti-VEGF bevacizumab na inflamação pleural e na pleurodese experimental induzida por talco ou nitrato de prata

Ribeiro¹

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À Profa. Dra Lisete Ribeiro Teixeira, respeitada pesquisadora, grande médica e, mais importante ainda, exemplo de caráter e de humanidade. Obrigada pelos muitos ensinamentos, pela disponibilidade, pela paciência e especialmente pela amizade e pelo apoio além de qualquer expectativa. À Dra Milena Acêncio, por colaborar com seu conhecimento e experiência em todas as fases deste trabalho e pela disposição incansável em ajudar e orientar. Ao Prof. Francisco Vargas por me acolher no grupo de Pleura e supervisionar o projeto que gerou esta tese. Aos Professores Evaldo Marchi e Leila Antonangelo, por sua valiosa contribuição para o aprimoramento deste trabalho. Ao Grupo da Pleura, cuja estrutura possibilitou a realização deste trabalho, especialmente ao Dr. Onishi, Carlos e Gabriela. Aos Professores Mário Terra Filho e Rogério de Souza em especial e à Pós-Graduação da Pneumologia, por todos os ensinamentos e pela experiência adquirida. Ao Dr. Pedro Medeiros e Dr. Rodrigo Brandão pela importância na minha formação, pela amizade de muitos anos e por me mostrarem, cada um a seu modo, de que é feito um grande médico.

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Comparison of sodium tetradecyl sulfate, bleomycin, and talc powder for rat pleurodesis induction

et al. 2019

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Malignant pleural effusion greatly alters patient's quality of life and pleurodesis significantly improves this index in these patients. Numerous agents have been introduced for pleurodesis. In this study, sodium tetradecyl sulfate (STS) is used for induction of pleurodesis and its efficacy is compared with other sclerosing agents: talc powder and bleomycin. Randomly divided four groups of rats undergone pleurodesis using STS, bleomycin, talc powder, and normal saline. The efficacy of each agent is investigated both microscopic and grossly. The most severe fibrosis was induced by bleomycin and STS respectively and this fibrosis was statistically significant in microscopic evaluation scales. Grossly the most severe fibrosis was induced by bleomycin. Talc Powder and STS caused less fibrosis but the same degree in gross evaluation. This study demonstrates the efficacy of STS for induction of pleurodesis in rat; however, further studies should be done for evaluation of its safety and efficacy in human subjects.

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Pleurodese: técnica e indicações

Cited by 10 publications

References 17 publications

Evaluation Of Quality Of Life In Patients With Pleurodesis

Evaluation Of Quality Of Life In Patients With Pleurodesis

Influência do anticorpo anti-VEGF bevacizumab na inflamação pleural e na pleurodese experimental induzida por talco ou nitrato de prata

Comparison of sodium tetradecyl sulfate, bleomycin, and talc powder for rat pleurodesis induction

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