Esophageal eosinophilia in pediatric patients with cerebral palsy

Abstract

Objective:To describe the clinical picture, test results, and clinical evolution of patients with cerebral palsy associated with diagnosis of eosinophilic esophagitis, monitored at tertiary centre.Methods:Cross-sectional, retrospective and descriptive study that evaluated the medical records data of pediatric patients with diagnosis of cerebral palsy and eosinophilic esophagitis in a tertiary center of pediatric gastroenterology between August 2005 and August 2013.Results:Seven out of 131 patients with cerebral palsy had the diagnosis of eosinophilic esophagitis. The mean age at diagnosis of eosinophilic esophagitis was 52.3 months and the mean number of eosinophils in esophagus was 35 per high-power field. Symptoms more frequent were recurrent vomiting and disphagia. Endoscopic alterations found were mucosal thickening, vertical lines, mucosal opacificacion and white plaques.Conclusion:The frequency of eosinophilic esophagitis found was higher than in general pediatric population. The investigation of eosinophilic esophagitis should be done regularly in those patients, once this entity could overlap other gastrointestinal diseases.

Cerebral palsy dysphagia: a systematic review

“…In them, it is confirmed that upper digestive alterations may trigger recurrent respiratory infections, insufficient nutritional intake, nutritional deficit in the growth curve, greater number of hospitalizations and the need for gastrostomy 1,10,11,15,[18][19][20][21] .…”

“…The early diagnosis of eosinophilic esophagitis is essential in CP patients and should be done carefully and should take into account the regular criteria, since the frequency of eosinophilic esophagitis in CP patients found in this study was high when compared to the presence of the same disease in the general population. Further studies are needed to establish a specific diagnosis and treatment in patients with cerebral palsy and esophageal eosinophilia 21 .…”

Incidence of Childhood Eosinophilic Esophagitis in Central Brazil: How Many Are We Missing?

“…The comparison between the groups of confirmed PPI responders and nonresponders did not show significant differences regarding gender, age, the presence of atopic children with psychomotor impairment, and although reflux disease is more common, we should suspect EoE in patients who do not respond to conventional GERD treatment [28].…”

Morphofunctional features of organs in children with cerebral palsy

“…В ретроспективном исследовании Napolis A. и др. с участием 131 ребенка с ДЦП, у 7 детей был диагностирован эозинофильный эзофагит [9]. В общей популяции детей распространенность ЭоЭ составляет 0,16-0,89 на 10 тыс.…”