Paullinia cupana para o controle de fogachos em pacientes com câncer de mama: um estudo piloto

Abstract

Objective:To evaluated whether Paullinia cupana decrease number and severity of hot flashes in breast cancer survivors.Methods:This was a prospective phase II pilot study. We studied female breast cancer survivors who had completed the cancer treatment 3 months previously and who were experiencing at least 14 hot flashes per week. At least 9 of the 15 patients were required to have a decrease of at least 50% in hot flash severity score in keeping with the Simon Design. Patients received 50mg of dry extract of Paullinia cupana orally twice a day for 6 weeks. We assessed both frequency and severity of hot flashes.Results:A total of 18 patients started the Paullinia cupana treatment, and 15 completed the study. Three patients left the study immediately after starting the treatment because of personal difficulties in participation or noncompliance. Of the 15 patients who completed the study 10 had a decrease of more than 50% in hot flash severity scores. During the 6 weeks of treatment, statistically significant decreases were seen in both numbers of hot flashes (p=0.0009) and severity scores (p<0.0001). Paullinia cupana was well tolerated, and there were no instances of discontinuation because of toxicity.Conclusions: Paullinia cupana appears promising for controlling hot flashes. More extensive studies seem warranted.

USO DE FERMENTAÇÃO POR LACTOBACILOS PARA AUMENTO DAS CARACTERÍSTICAS ANTIOXIDANTES DE Theobroma grandiflorum

“…The decreasing of hot flashes in breast cancer survivors (OLIVEIRA et al, 2013), and in LDL oxidation in elderly people (PORTELLA et al, 2013), besides weight stabilization (PALMA et al, 2016) were health aspects associated with catechins present in guarana.…”

A systematic review of non-hormonal treatments of vasomotor symptoms in climacteric and cancer patients

“…Herbal supplements are widely used for vasomotor symptoms, with varying degrees of efficacy. Among the more frequently studied are hops (Heyerick et al 2006 ; Erkkola et al 2010 ), red clover (Hidalgo et al 2005 ; Geller et al 2009 ; Lipovac et al 2012 ), flaxseed (Lewis et al 2006 ; Colli et al 2012 ; Pruthi et al 2012 ), St. John’s Wort ( Hypericum perforatum ) (Al-Akoum et al 2009 ; Abdali et al 2010 ; Uebelhack et al 2006 ; Briese et al 2007 ), evening primrose ( Oenothera biennis ) (Farzaneh et al 2013 ), French maritime pine bark (Pycngenol) (Yang et al 2007 ; Kohama & Negami 2013 ); Sibiric Rhubarb ( Rheum rhaponticum ) (Heger et al 2006 ; Kaszkin-Bettag et al 2007 ; Kaszkin-Bettag et al 2009 ; Hasper et al 2009 ), valerian root ( Valeriana officinalis ) (Mirabi & Mojab 2013 ), Guaraná (Paullinia cupana ) (Oliveira et al 2013 ), and magnesium (Park et al 2011 ). Summaries of these studies can be found in Additional file 1 .…”

Use of Guarana for Hot Flashes after Breast Cancer: Randomized, Double-Blind, Placebo-Controlled Phase II Trial

“…A pilot study conducted with women taking adjuvant hormone therapy due to breast cancer who had hot flashes showed that the use of non-purified dry extract of guarana at a dose of 50 mg twice daily for 6 weeks had significant effects on the amount (p = 0.0009) and intensity (p < 0.0001) of the hot flashes, with great tolerance and there was no discontinuation due to toxicity 35 . However, the interpretation of the efficacy of various agents studied for hot flashes, as exemplified above, are subject to the direct influence of the placebo effect, which is responsible for reducing hot flashes 20 to 50 % 41 .…”