New World Health Organization reference values for semen analysis: where do we stand?

Vieira, Marcelo

doi:10.1590/s1679-45082013000200023

Cited by 7 publications

(5 citation statements)

References 4 publications

(12 reference statements)

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“…In addition, the new reference values were derived from data belonging to fertile men from Europe, Australia and North America, thus ignoring the vast majority of fertile men living in Africa, Asia, Middle East and South America. Recent controlled prospective studies confirmed regional differences between countries and continents as regards semen quality (Ellekilde Bonde, ; Vieira, ). Therefore, a major concern surrounded the ability of the new reference values for human semen to represent fertile men worldwide.…”

Section: Introductionmentioning

confidence: 82%

Evaluation of reference values of standard semen parameters in fertile Egyptian men

et al. 2018

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SummaryThe reference values of human semen, published in the WHO's latest edition in 2010, were lower than those previously reported. The objective of this study was to evaluate reference values of standard semen parameters in fertile Egyptian men. This cross-sectional study included 240 fertile men. Men were considered fertile when their wives had recent spontaneous pregnancies with time to pregnancy (TTP) ≤12 months. The mean age of fertile men was 33.8 ± 0.5 years (range 20-55 years). The 5th percentiles (95% confidence interval) of macroscopic semen parameters were 1.5 ml for volume and 7.2 for pH. The 5th percentiles of microscopic parameters were 15 million/ml for sperm concentration, 30 million per ejaculate for total sperm count, 50% for total motility, 40% for progressive motility, 62% for vitality, 4% for normal sperm forms and 0.1 million/ml for seminal leucocyte counts. In conclusion, fertile Egyptian men had higher reference values of sperm total motility, progressive motility and vitality, and lower reference values for total sperm counts as compared to those determined by the latest edition of the WHO laboratory manual in 2010. Other semen parameters were identical to those defined by the WHO 2010 manual. | IntroductionStandard procedures of semen analysis are routinely used in most laboratories for initial evaluation of male fertility potential. These procedures include initial macroscopic examination of semen appearance, liquefaction, volume, viscosity and pH; and microscopic investigation of sperm concentration, motility and morphology; and assessment of seminal leucocytes and immature germ cells (WHO, 2010). Despite its weaknesses as a diagnostic tool, standard semen analysis allows for detection of remarkable cases of infertility such as azoospermia (Saleh et al., 2002). In addition, with repetitively abnormal semen analyses results, men can be diagnosed as infertile and an approximate prognosis can be given.The methods of human semen evaluation are provided by the WHO, which periodically releases manuals including specific protocols and reference standards (Esteves, 2014). The WHO published its updated 5th edition of the laboratory manual for the examination of human semen in late 2010. This latest edition of the manual established reference values derived from data belonging to eight countries located in three continents from 1953 fertile men with a time to pregnancy (TTP) of <1 year (Cooper et al., 2010). The new reference values

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Section: Introductionmentioning

confidence: 82%

Evaluation of reference values of standard semen parameters in fertile Egyptian men

et al. 2018

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“…As per the WHO's amended guidelines, their male partners' semen analytical parameters were normal. 13 Intervention: Group I: 100 cases received letrozole (FEMARA 2.5 MG, Novartis company) (dose: 5.0 mg/d −1 on the 3 rd -7 th days of the menstrual period for five consecutive days). If the patient did not conceive, the therapy has been repeated for another cycle.…”

Section: Methodsmentioning

confidence: 99%

Comparing Effectiveness of Letrozole versus Postmenopausal FSH in Patients with Clomiphene Citrate-Resistant Polycystic Ovary Syndrome

Shafey

Ahmed²,

Sultan³

2022

Al-Azhar International Medical Journal

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Background: Follicle-stimulating hormone (FSH) is known for inducing multi-follicular growth in women. Letrozole (LE) is a third-generation aromatase inhibitor (AI) that is both powerful and selective. It was found to be effective in inducing ovulation, increased pregnancy rate, improve uterine environment, endometrial development with favorable cervical mucus. Aim of the work:To assess the effectiveness of Letrozole with postmenopausal FSH in the treatment of anovulation in Clomiphene Citrate-Resistant Polycystic Ovary Syndrome. Patients and methods: This was a randomized-controlled clinical trial involving 200 females with PCOS who were recruited from outpatient clinics at Al-Hussien University Hospital and Kafr EL-Sheikh General Hospital at the start of the study and followed up with after intervention to record the results from June 2020 to June 2021. Results: The rate of ovulation has slightly been better in the postmenopausal FSH group (58%) compared to the letrozole group (54%), but without a significant difference (P=0.569) with the mean value ± SD for the overall number of follicles throughout activation being considerably larger in the postmenopausal FSH group (2.12 ± 1.35) versus (1.7 ±0.99) in the letrozole group; P=0.05). Out of those ovulating cases, 63% had single follicles compared to 50% in the postmenopausal FSH group and the remaining had multiple follicles, 37% versus 50% in both groups, respectively. Conclusion: Letrozole and postmenopausal FSH were both beneficial in the treatment of patients with CC-resistant PCOS. Both medications were well tolerated, although letrozole was significantly easier to administer and less expensive.

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“…The first stage of the fertility assessment method involves analyzing the sperm count, morphology, and motility of the semen. Additional investigations such as sperm chromatin evaluation, acrosome response, ROS, and chemical testing of SP are also feasible [ 72 ]. It is essential to perform several analyses in order to have a more complete understanding of fecundity.…”

Section: Current Status Of Male Infertility Assessment and Indexes Fo...mentioning

confidence: 99%

Integrative Assessment of Seminal Plasma Biomarkers: A Narrative Review Bridging the Gap between Infertility Research and Clinical Practice

Moustakli,

Zikopoulos,

Skentou

et al. 2024

JCM

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Infertility represents a significant global health challenge impacting millions of couples worldwide. Approximately half of all infertile couples exhibit compromised semen quality, indicative of diminished male fertility. While the diagnosis of male infertility traditionally relies on semen analysis, its limitations in providing a comprehensive assessment of male reproductive health have spurred efforts to identify novel biomarkers. Seminal plasma, a complex fluid containing proteins, lipids, and metabolites, has emerged as a rich source of such indicators. Reproduction depends heavily on seminal plasma, the primary transporter of chemicals from male reproductive glands. It provides a non-invasive sample for urogenital diagnostics and has demonstrated potential in the identification of biomarkers linked to illnesses of the male reproductive system. Τhe abundance of seminal proteins has enabled a deeper understanding of their biological functions, origins, and differential expression in various conditions associated with male infertility, including azoospermia, asthenozoospermia, oligozoospermia, teratozoospermia, among others. The true prevalence of male infertility is understated due to the limitations of the current diagnostic techniques. Τhis review critically evaluates the current landscape of seminal plasma biomarkers and their utility in assessing male infertility. Βy bridging the gap between research and clinical practice, the integrative assessment of seminal plasma biomarkers offers a multimodal approach to comprehensively evaluate male infertility.

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New World Health Organization reference values for semen analysis: where do we stand?

Cited by 7 publications

References 4 publications

Evaluation of reference values of standard semen parameters in fertile Egyptian men

Evaluation of reference values of standard semen parameters in fertile Egyptian men

Comparing Effectiveness of Letrozole versus Postmenopausal FSH in Patients with Clomiphene Citrate-Resistant Polycystic Ovary Syndrome

Integrative Assessment of Seminal Plasma Biomarkers: A Narrative Review Bridging the Gap between Infertility Research and Clinical Practice

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