Relationship between sleep deprivation and anxiety: experimental research perspective

Pires, Gabriel Natan; Tufik, Sérgio; Andersen, Mônica Levy

doi:10.1590/s1679-45082012000400022

Cited by 10 publications

(14 citation statements)

References 24 publications

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“…The EPM test was used to assess the anxiety-like behavior of rodents, being considered the gold standard for the evaluation of anxiety in basic research (Pires et al 2012 …”

Section: Anxiety-like Behavior Testsmentioning

confidence: 99%

Modulatory effects of caffeine on oxidative stress and anxiety-like behavior in ovariectomized rats

Caravan

Berghian

Moldovan

et al. 2016

Can. J. Physiol. Pharmacol.

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Menopause is accompanied by enhanced oxidative stress and behavioral changes, effects attenuated by antioxidants. The aim of this study was to evaluate the effects of caffeine on behavior and oxidative stress in an experimental model of menopause. Female rats were divided in: sham-operated (CON), sham-operated and caffeine-treated (CAF), ovariectomized (OVX), ovariectomized and caffeinetreated (OVX+CAF). Caffeine (6 mg/kg) and vehicle were administered for 21 days (subchronic) and 42 days (chronic), using 2 experimental subsets. Behavioral tests and oxidative stress parameters in the blood, whole brain and hippocampus were assessed. The subchronic administration of caffeine decreased the lipid peroxidation and improved the antioxidant defense in the blood and brain. The GSH/GGSG ratio in the brain was improved by chronic administration, with reduced activities of antioxidant enzymes and enhanced nitric oxide and malondialdehyde levels. In particular, the lipid peroxidation in the hippocampus decreased in both experiments. The rats became hyperactive after 21 days of treatment, but no effect was observed after chronic administration. In both experimental subsets, caffeine had anxiolytic effects as tested in EPM. The administration of low doses of caffeine, for a short period of time, may be a new therapeutic approach to modulating the oxidative stress and anxiety in menopause.

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“…The EPM test was used to assess the anxiety-like behavior of rodents, being considered the gold standard for the evaluation of anxiety in basic research (Pires et al 2012 …”

Section: Anxiety-like Behavior Testsmentioning

confidence: 99%

Modulatory effects of caffeine on oxidative stress and anxiety-like behavior in ovariectomized rats

Caravan

Berghian

Moldovan

et al. 2016

Can. J. Physiol. Pharmacol.

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“…High levels of anxiety have a negative impact on attention, memory and problem solving (as components of cognitive performance), whereas low and moderate anxiety levels are related to better cognitive performance [ 26 ]. Anxiety has been described as one of the most important consequences of sleep deprivation [ 27 ] and sleep deprivation has a substantial effect on mood and motor and cognitive performance in humans. [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Quality of sleep and anxiety are related to circadian preference in university students

2020

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Chronotype is a circadian phenotype expressed in the preference of individuals to perform their activities and sleep in specific phases along the day. The objective of the study was to identify anxiety levels, quality of sleep and different chronotypes of university students and investigate their possible relationships. This is a cross-sectional study with a quantitative approach, in which 103 undergraduate students answered the Morningness-Eveningness Questionnaire (MEQ) the State and Trait Anxiety Inventory (STAI) and the Pittsburgh Sleep Quality Index (PSQI). There is a relationship between chronotype, quality of sleep and anxiety in the investigated population. Evening chronotype students showed higher anxiety status and have poor sleep quality when compared with morning chronotype students. The high occurrence of anxiety levels and poor sleep quality in evening students may be a consequence of high academic demand in a shift incompatible with the phase delay of the circadian timing system of these individuals.

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“…The effects of acute sleep deprivation on anxiety have produced some controversy in the literature, mainly when considered from a translational perspective (Nunes, Pezzato, & Hoshino, 2012; Pires, Tufik, & Andersen, 2012, 2013; Silva et al, 2004; Tufik, Andersen, Bittencourt, & Mello, 2009). While clinical studies point to an increase in anxiety due to sleep deprivation, the results of animal experiments have been inconsistent.…”

mentioning

confidence: 99%

Sleep deprivation and anxiety in humans and rodents—Translational considerations and hypotheses.

Pires¹,

Tufik²,

Andersen³

2015

Behavioral Neuroscience

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The effects of acute sleep deprivation on anxiety are the focus of controversy in the literature. While clinical research studies on the effects of sleep deprivation seem to show a consistent increase in acute anxiety, rodent studies have produced inconsistent results, with some experiments pointing to anxiogenesis and others to anxiolysis. Such observations impair the translational applicability of rodent models on the paradigm between sleep deprivation and anxiety. Current studies fail in the very basic principle of biomedical translational research: to provide relevant and reliable knowledge from basic experimental science that can be applied in clinical environments. Possible explanations for the disparity between human and animal studies include the accuracy of both human and rodent research, the ability of current behavioral protocols to truly reflect the anxiety response of rodents to sleep deprivation, and the nature of sleep deprivation-induced anxiety in rodents. Based on these hypotheses, we performed a brief overview of the literature on the relationship between sleep deprivation and anxiety and propose a research agenda that could lead to a better understanding of the reasons for the discrepancies found in the literature and provide more reliable data on the translational relationship between sleep deprivation and anxiety.

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Relationship between sleep deprivation and anxiety: experimental research perspective

Cited by 10 publications

References 24 publications

Modulatory effects of caffeine on oxidative stress and anxiety-like behavior in ovariectomized rats

Modulatory effects of caffeine on oxidative stress and anxiety-like behavior in ovariectomized rats

Quality of sleep and anxiety are related to circadian preference in university students

Sleep deprivation and anxiety in humans and rodents—Translational considerations and hypotheses.

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