Multiple myeloma: five-year experience at a University Hospital

Todaro, Juliana; Bigonha, Jandey; Borducchi, Davimar Miranda Maciel; Matos, Leandro Luongo de; Trufelli, Damila Cristina; Sales, Suzane Martines Alves de; Shiroma, Marina; Giglio, Auro del

doi:10.1590/s1679-45082011ao2006

Cited by 2 publications

(3 citation statements)

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“…Multiple myeloma bone lesions arise from altered bone remodeling due to both increased osteoclast activation and decreased osteoblast differentiation. 15 Bone involvement in our study is in concurrence with the study conducted by Todaro et al, 14 who found 74% of patients of multiple myeloma had osteolytic lesions.…”

Section: Discussionsupporting

confidence: 92%

“…The incidence of renal involvement is slightly higher in studies conducted by Dawson et al and Kyle et al, who have found an incidence of 45% and 55%, respectively. 13 Hypercalcemia was found in 32% of patients in our study, which is comparable to the study done by Vahini et al 9 and Todaro et al 14 In our study, 73% of patients had osteolytic lesions showing varied skeletal involvement in radiological investigations. Bone disease in multiple myeloma results in severe bone pain, pathological fractures, and hypercalcemia.…”

Section: Discussionsupporting

confidence: 90%

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Clinico-hematological profile of multiple myeloma in a teaching hospital - A 2 year study

Sheik¹,

Variganji²,

Inuganti³

et al. 2020

ACHR

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Multiple myeloma accounts for 1% of all cancers and 10-15% of all hematologic malignancies. It is characterized by bone marrow infiltration with clonal plasma cells, production of monoclonal immunoglobulin, and associated end-organ damage. The study aims to find out the incidence of multiple myeloma and to study the clinico-hematological profile along with radiological features. Materials and Methods: The present study was done both retrospectively and prospectively in 26 patients of multiple myeloma diagnosed over a period of 2 years from June 2017 to June 2019 in our teaching hospital. Data from hematological, biochemical, and radiological investigations were collected. For evaluation of each case, revised International Myeloma Working Group criteria were applied. Results: 26 patients were diagnosed during the study period, with the majority of them in the 6 th decade with age range was 41-74 years. The male to female ratio was 1.3:1. Most common clinical feature was fever (50%) followed by bone pains (42%) and generalized weakness (42 %). Anemia was the most common hematological manifestation. All the patients had 'M band' on serum electrophoresis, and 27% of patients had urinary Bence Jones proteins. Among the skeletal system, the spine (63%) is the most common site of involvement. Conclusion: Among the 26 patients, various clinical presentations observed were pathological fracture, infections, renal impairment, generalized weakness in addition to anemia, and bone pains. Multiple myeloma should be considered as a differential diagnosis in old age patients presenting with such complaints.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Clinico-hematological profile of multiple myeloma in a teaching hospital - A 2 year study

Sheik¹,

Variganji²,

Inuganti³

et al. 2020

ACHR

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“…In Brazil, the mean age at diagnosis is 10 years lower than those reported in published literature, and this fact can be explained given that the most of diagnoses occur at advanced stages. (4,5) The clinical presentation of MM is variable, and the chain of myeloma development, which possibly begins from monoclonal gammopathy, may be mediated by a condition called "smoldering myeloma". This, as suggested by its name, does not present symptoms despite the presence of 10% plasma cells and evidence of a monoclonal protein (diagnostic criterion).…”

Section: ❚ Introductionmentioning

confidence: 99%

Cross-cultural translation and adaptation of Functional Assessment of Cancer Therapy – Multiple Myeloma tool – MM1 and LEU3 – for Portuguese

Todaro¹,

Souza²,

Pietrocola³

et al. 2022

Einstein (São Paulo)

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Objective: To describe of the translation from English to Portuguese and adaption process of subitems of the Functional Assessment of Cancer Therapy -Multiple Myeloma. Methods: In the first phase, translations from English into Portuguese of two subitems of Functional Assessment of Cancer Therapy -Multiple Myeloma were performed. Subsequently, a consensus and back translation were conducted, and, finally, translation and back translations were reviewed by four independent bilingual experts. In the second phase, the translated subitems were applied, along with a questionnaire, to 10 native Portuguese speakers patients with multiple myeloma. Results: There was a recognition of the translation process in its first version applied to 10 patients with multiple myeloma, whose reported no difficult to understand the translated and validated instrument. Patients also did not find the content irrelevant or offensive, and they did not suggested changes. Conclusion: The subitems of the Functional Assessment of Cancer Therapy -Multiple Myeloma were translated from English into Portuguese following the proposed methodology and there was not need of readjustments. This process allowed this instrument of quality of life, which is widely known to be beneficial in the management of patients with multiple myeloma, to be used among our population.

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Multiple myeloma: five-year experience at a University Hospital

Abstract: This set of cases from a tertiary public healthcare service reflect the approach of multiple myeloma in a predominantly young population with advanced clinical staging, with results comparable to those of the literature.

Cited by 2 publications

References 16 publications

Clinico-hematological profile of multiple myeloma in a teaching hospital - A 2 year study

Clinico-hematological profile of multiple myeloma in a teaching hospital - A 2 year study

Cross-cultural translation and adaptation of Functional Assessment of Cancer Therapy – Multiple Myeloma tool – MM1 and LEU3 – for Portuguese

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