SARS-CoV-2 reinfection caused by the P.1 lineage in Araraquara city, Sao Paulo State, Brazil

Romano, Camila Malta; Félix, Alvina Clara; A, de Paula; Jesus, Jaqueline Góes de; Andrade, Pâmela S; Cândido, Darlan da Silva; Oliveira, Franciane Mendes de; Ribeiro, A; Silva, Francini C da; Inemami, Marta; Costa, André Oliveira; Leal, Cibele O D; Figueiredo, Walter Manso; Pannuti, Cláudio Sérgio; Souza, William Marciel de; Faria, Nuno Rodrigues; Sabino, Éster Cerdeira

doi:10.1590/s1678-9946202163036

Cited by 35 publications

(31 citation statements)

References 14 publications

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“…P.1 (VOC), recently named as Gamma variant by the newly WHO nomenclature proposal 5 as well as P.2 (VOI) variants have evolved from the lineage B.1.1.28 1 , 2 and harbor E484K (P.1 and P.2) and N501Y (P.1) mutations, which are associated with increased transmissibility or immune evasion 6 . The persistence of protective immunity provided by the coronavirus disease 2019 (COVID-19) or vaccination is not yet well established and some cases of reinfection have been reported 7 , 8 .…”

Section: Introductionmentioning

confidence: 99%

Early detection of SARS-CoV-2 P.1 variant in Southern Brazil and reinfection of the same patient by P.2

Silva

Demoliner

Hansen

et al. 2021

Rev. Inst. Med. trop. S. Paulo

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Section: Introductionmentioning

confidence: 99%

Early detection of SARS-CoV-2 P.1 variant in Southern Brazil and reinfection of the same patient by P.2

Silva

Demoliner

Hansen

et al. 2021

Rev. Inst. Med. trop. S. Paulo

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“…noted the re‐infection cases by the P.1 variants in São Paulo city of Brazil. 48 At the same time, four re‐infection cases by the B.1.351 were recorded in Luxembourg. 44 Researchers reported that a higher transmission rate was noted in B.1.1.7 with 43%–82%.…”

Section: New Variants and Their Impact On Transmissibility Infectivity And Re‐infectivitymentioning

confidence: 94%

“…47 The variant is also accountable for the re‐infection of the São Paulo State. 48 The variant got transmitted outside Brazil and circulated in different countries throughout the world. Di Giallonardo et al.…”

Section: Properties Of the Significant Vocsmentioning

confidence: 99%

Present variants of concern and variants of interest of severe acute respiratory syndrome coronavirus 2: Their significant mutations in S‐glycoprotein, infectivity, re‐infectivity, immune escape and vaccines activity

Chakraborty

Bhattacharya

Sharma

2021

Reviews in Medical Virology

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Summary Newly arising variants of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) are now a threat to global public health and are creating COVID‐19 surges in different countries. At the same time, there is limited knowledge about these emerging variants. Even if research data are available, it is varyingly scattered. In this review, we have discussed the appearance of significant alarming SARS‐CoV‐2 variants in the entire world. The study also discusses the properties of the substantial variant of concern (VOC) variants such as B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma), B.1.427 (Epsilon) and B.1.429 (Epsilon). At the same time, the characteristic properties of some significant variant of interest (VOI) variants like B.1.525 (Eta), B.1.526 (Iota) (sublineage B.1.526.1), B.1.617 (sublineages B.1.617.1 (Kappa), B.1.617.2 (Delta) and B.1.617.3), P.2 (Zeta), P.3 (Theta), B.1.616 and B.1.427 have also been discussed. Here, we have explained some essential mutations for the VOC and VOI variants such as K417T/N, L452R, E484K, N501Y, D614G and P681R. Consecutively, we also highlighted the crucial clinical characteristics of the variants, such as transmissibility, infectivity, re‐infectivity, immune escape, vaccine activity and vaccine escape. Our comprehensive review will provide updated information on the newly appearing variants of SARS‐CoV‐2 and help the researchers to formulate strategies to curtail the COVID‐19 pandemic.

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“…The copyright holder for this preprint this version posted July 31, 2021. ; https://doi.org/10.1101/2021.07.28.21261228 doi: medRxiv preprint 20,21,22 . Although several studies documented P.1's increased transmissibility 15,23 and immune evasion 20,22,[24][25][26] , little is known about its association with the severity of COVID-19 disease and mortality risk, which is crucial to better understand and mitigate the severe impact of the ongoing pandemic. of the administered doses 27 , respectively.…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies have reported that P.1 lineage presents an increase in ACE2 receptor affinity due to the presence of the N501Y mutation 16,18 , which significantly impacts its transmissibility rate, shown to be 1.4-2.2-fold higher than the wild type strain 13 . Moreover, P.1 also exhibited a reduction of anti-RBD antibody neutralization 19 , and it has been implicated in breakthrough infections of vaccinated individuals as well as reinfections 20,21,22 . Although several studies documented P.1’s increased transmissibility 15,23 and immune evasion 20,22,24–26 , little is known about its association with the severity of COVID-19 disease and mortality risk, which is crucial to better understand and mitigate the severe impact of the ongoing pandemic.…”

Section: Introductionmentioning

confidence: 99%

Effects of SARS-CoV-2 P.1 introduction and the impact of COVID-19 vaccination on the epidemiological landscape of São José Do Rio Preto, Brazil

Banho

Sacchetto

Campos

et al. 2021

Preprint

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The emergence of the new Brazilian variant of concern, P.1 lineage (Gamma), raised concern about its impact on the epidemiological profile of COVID-19 cases due to its higher transmissibility rate and immune evasion ability. Using 272 whole-genome sequences combined with epidemiological data, we showed that P.1 introduction in Sao Jose do Rio Preto, Sao Paulo, Brazil, was followed by the displacement of eight circulating SARS-CoV-2 variants and a rapid increase in prevalence two months after its first detection. Our findings support that the P.1 variant is associated with an increase in mortality risk and severity of COVID-19 cases in younger aged groups, which corresponds to the unvaccinated population at the time. Moreover, our data highlight the beneficial effects of vaccination indicated by a pronounced reduction of severe cases and deaths in immunized individuals, reinforcing the need for rapid and massive vaccination.

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SARS-CoV-2 reinfection caused by the P.1 lineage in Araraquara city, Sao Paulo State, Brazil

Cited by 35 publications

References 14 publications

Early detection of SARS-CoV-2 P.1 variant in Southern Brazil and reinfection of the same patient by P.2

Early detection of SARS-CoV-2 P.1 variant in Southern Brazil and reinfection of the same patient by P.2

Present variants of concern and variants of interest of severe acute respiratory syndrome coronavirus 2: Their significant mutations in S‐glycoprotein, infectivity, re‐infectivity, immune escape and vaccines activity

Effects of SARS-CoV-2 P.1 introduction and the impact of COVID-19 vaccination on the epidemiological landscape of São José Do Rio Preto, Brazil

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