Late acute pulmonary embolism after mild Coronavirus Disease 2019 (COVID-19): a case series

Vechi, Hareton Teixeira; Maia, Lucas Rodrigues; Alves, Manoella do Monte

doi:10.1590/s1678-9946202062063

Cited by 34 publications

(46 citation statements)

References 33 publications

(55 reference statements)

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“…The correlation between thrombotic complications and elevated levels of D-dimer in COVID-19 patients has also been reported [1,9]. One study reported the occurrence of PE in mild COVID-19; however, the presence or absence of associated parenchymal involvement was not mentioned [8].…”

Section: Discussionmentioning

confidence: 94%

“…One study reported the occurrence of PE in mild COVID-19; however, the presence or absence of associated parenchymal involvement was not mentioned [ 8 ]. Another case series reported late acute PE in patients with mild COVID-19; however, the patients in the case series were noted to have lung infiltrates [ 9 ]. The occurrence of PE even in mild COVID-19 has significant implications since the initiation of anticoagulation presumptively in patients with elevated D-dimers has been shown to improve mortality rates [ 10 , 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

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Submassive Pulmonary Embolism in Mild COVID-19 Without Lung Infiltrates

Manek¹,

Gupta²,

Congrete³

et al. 2021

Cureus

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A 66-year-old man who had been diagnosed with mild coronavirus 2019 (COVID-19) infection nine days prior presented to the emergency room with acute-onset chest pain and shortness of breath. Chest CT angiogram (CTA) revealed pulmonary emboli (PE) in the right and left pulmonary arteries with right heart strain; lung parenchyma showed no infiltrates. Although severe COVID-19 infection is associated with thrombotic complications, data regarding the occurrence of PE in mild cases of COVID-19 is scarce. However, even mild cases of COVID-19 are reported to have revealed lung infiltrates, particularly groundglass opacities, on imaging. The possibility of the lungs being the primary source of COVID-19-associated coagulopathy has been raised. We report an uncommon case of submassive PE occurring in mild COVID-19, without any associated lung infiltrates. This case indicates that mild COVID-19, without significant lung parenchymal involvement, can also cause a hypercoagulable state, resulting in venous thromboembolism (VTE).

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Submassive Pulmonary Embolism in Mild COVID-19 Without Lung Infiltrates

Manek¹,

Gupta²,

Congrete³

et al. 2021

Cureus

View full text Add to dashboard Cite

show abstract

“…The recommendation to continue combined hormonal contraceptives in patients with COVID-19 disregards the fact that patients with COVID-19 may have several coagulation abnormalities that suggest a hypercoagulable state [5,6]. Though more commonly identified in patients with COVID-19 and severe illness, contrary to common belief, patients with only mild symptoms may also manifest hypercoagulable state as evidenced by the development of venous thromboembolic events in this patient population [7,8]. Therefore, we believe a more appropriate action would be to discontinue any forms of combined hormonal contraceptives in patients with suspected or confirmed COVID-19.…”

Section: The Use Of Combined Hormonal Contraceptives Amid the Covid-1mentioning

confidence: 99%

The use of combined hormonal contraceptives amid the COVID-19 pandemic

Kow

Mustafa

Hasan

2020

The European Journal of Contraception & Reproductive Health

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“…Indeed, an abnormally high incidence of venous thromboembolic events has been observed particularly in patients suffering from severe forms and hospitalized in intensive care [ 5 , 6 ]. But in a minority of patients with non-severe forms of the disease, the silent thrombogenicity associated with SARS-CoV-2 can sometimes complicate the clinical condition of patient despite the recovery [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Late pulmonary embolism in a patient with non-severe COVID-19: case report, value of antithrombotic prophylaxis and review of the literature

Maloumbi¹,

Hassouni²,

Ibara-Onguema³

et al. 2021

Pan Afr Med J

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Since the onset of the COVID-19 pandemic, several small cohorts have reported the recurrent occurrence of venous thromboembolic disease (VTE), particulary pulmonary embolism, in serious patients hospitalized in intensive care units. We report the case of a patient who presented a minor COVID-19 infection treated on an outpatient basis with good clinical resolution. She developed a pulmonary embolism three weeks after the onset of symptoms. When she was admitted to the emergency room, the two real time reverse transcription polymerase chain reactions (RT-PCRs) performed were negative, moreover the anti-SARS-CoV-2 Immunoglobulin Gs (IgGs) serological test was positive and the chest scanner without and with injection of contrast product showed specific images of COVID-19 with intermediate pulmonary embolism according to the classification of the European society of cardiology (ESC). This observation is interesting since there are not many studies which address the question of the occurrence of late pulmonary embolism in patients with non-severe COVID-19 and raises the discussion on the criteria for the initiation of thromboembolic prophylaxis treatment at the first diagnosis of the disease and duration of that treatment.

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Late acute pulmonary embolism after mild Coronavirus Disease 2019 (COVID-19): a case series

Abstract: This is an open-access article distributed under the terms of the Creative Commons Attribution License.

Cited by 34 publications

References 33 publications

Submassive Pulmonary Embolism in Mild COVID-19 Without Lung Infiltrates

Submassive Pulmonary Embolism in Mild COVID-19 Without Lung Infiltrates

The use of combined hormonal contraceptives amid the COVID-19 pandemic

Late pulmonary embolism in a patient with non-severe COVID-19: case report, value of antithrombotic prophylaxis and review of the literature

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