Prevalence and molecular typing of rotavirus in children with acute diarrhoea in Northeastern Colombia

Martínez-Gutiérrez, Marlen; Arcila-Quiceno, Víctor; Trejos-Suárez, Juanita; Ruíz-Saenz, Julián

doi:10.1590/s1678-9946201961034

Cited by 10 publications

(11 citation statements)

References 34 publications

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“…We believe that the emergence of Wa-1 equine-like G3P [8] in this study may be the result of a rearrangement between a non-previously reported equine-like-DS-1 variants and a local Wa-like strain as has been reported elsewhere [29]. Since G12P [8] strains have been recently reported in Colombia [6], it could be possible that backbone strains belong to local G12P [8] with a high identity (>99.4%) to human G12P [8] strains from Spain (Table 1).…”

Section: Discussionsupporting

confidence: 67%

“…A recently published case-control study assessing the etiology of moderate to severe acute gastroenteritis in children that were less than 5 years of age, carried out in the same city from the patient of our current study (Bucaramanga, Colombia), found that norovirus and rotavirus explained the major proportion of moderate to severe clinical cases [35]. However, after the introduction of RVA vaccination in 2009, there was a reduction of 39% in diarrhea-related mortality in children <5 years old (95% CI, 35 to 44) in Colombia [36], with a rapid switch from Wa-like to DS-1-like strains [37] and a high frequency of unusual G9P [4] in 2012 [38] and G3 P[8]/P [9] strains accounting for the vast majority of cases (82.8%) in 2015-2016 [6]. As has been seen in other countries in Latin America, the strong bias towards G3 strains, mainly in Brazil, is mostly due to the presence of the Equine-like RVA strains [12,15].…”

Section: Discussionmentioning

confidence: 99%

“…This was a retrospective and descriptive study conducted in a G3P [8] positive sample belonging to a cohort study previously analyzed [6]. Sample (RVA/Human-wt/COL-BUC/55/2015/G3P [8]) belonged to a two-year-old child who presented with acute gastroenteritis at a public hospital belonging to the Bucaramanga Institute of Health-ISABU in the north-eastern region of Colombia in November 2015.…”

Section: Type Of Study and Samplesmentioning

confidence: 99%

“…Specifically in Bucaramanga City (the north-eastern region of Colombia), prior to the vaccine introduction, RVA was considered the main cause of diarrheal disease in children under five years who consulted emergency services, accounting for 44.4% (95% confidence interval [CI] 37.1-52.0) of the reported cases [5]. Recent data showed that the prevalence of rotavirus infections had decreased to 30.53% (95% [CI] = 21.2-39.7%) [6].…”

Section: Introductionmentioning

confidence: 99%

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Wa-1 Equine-Like G3P[8] Rotavirus from a Child with Diarrhea in Colombia

Martínez-Gutiérrez

Hernández-Mira

Rendón-Marín

et al. 2021

Viruses

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Rotavirus A (RVA) has been considered the main cause of diarrheal disease in children under five years in emergency services in both developed and developing countries. RVA belongs to the Reoviridae family, which comprises 11 segments of double-stranded RNA (dsRNA) as a genomic constellation that encodes for six structural and five to six nonstructural proteins. RVA has been classified in a binary system with Gx[Px] based on the spike protein (VP4) and the major outer capsid glycoprotein (VP7), respectively. The emerging equine-like G3P[8] DS-1-like strains reported worldwide in humans have arisen an important concern. Here, we carry out the complete genome characterization of a previously reported G3P[8] strain in order to recognize the genetic diversity of RVA circulating among infants in Colombia. A near-full genome phylogenetic analysis was done, confirming the presence of the novel equine-like G3P[8] with a Wa-like backbone for the first time in Colombia. This study demonstrated the importance of surveillance of emerging viruses in the Colombian population; furthermore, additional studies must focus on the understanding of the spread and transmission dynamic of this important RVA strain in different areas of the country.

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Section: Type Of Study and Samplesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Wa-1 Equine-Like G3P[8] Rotavirus from a Child with Diarrhea in Colombia

Martínez-Gutiérrez

Hernández-Mira

Rendón-Marín

et al. 2021

Viruses

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“… 7–10 Others found no sex differences in incidence. 11 , 12 Rotaviral enteritis among adults has not decreased despite effective vaccination in childhood; infections with rotavirus among adults are generally underappreciated by age and sex 13 , 14 and may spread between patients, making recognition of rotaviral enteritis important for infection control. 15–17 …”

Section: Introductionmentioning

confidence: 99%

A Pooled Analysis of Sex Differences in Rotaviral Enteritis Incidence Rates in Three Countries Over Different Time Periods

Peer

Schwartz

Green

2022

Women's Health Reports

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Background: Sex differences in incidence rates (IRs) of infectious diseases could provide clues to the mechanisms of infection. The results of studies on sex differences in the incidence of rotaviral enteritis have been inconsistent. Methods: We carried out a pooled analysis of sex differences in IRs for rotaviral enteritis in three countries for a period of 7–22 years. Male-to-female incidence rate ratios (IRRs) were computed by age group, country, and years of reporting. A meta-analytic methodology was used to combine IRRs. Metaregression was performed to evaluate the contribution of age group, country, and years of reporting to the IRR. Results: Significantly higher IRs in males were found in the age groups 0–4, 5–9, and 10–14 years, with pooled IRRs (with 95% confidence intervals [CIs]) of 1.12 (1.09–1.14), 1.07 (1.05–1.09), and 1.13 (1.05–1.21), respectively. In adults, the sex differences were reversed with higher rates in females. The pooled male-to-female IRRs (with 95% CIs) were 0.66 (0.64–0.68), 0.78 (0.72–0.85), and 0.78 (0.72–0.84) for the age groups 15–44, 45–64, and 65+ years, respectively. Metaregression results demonstrated that age is responsible for much of the variation in IRRs. Conclusions: The higher rotaviral enteritis IRs in males at a very early age suggest that sex-related factors unrelated to exposure may play a role. The higher IRs in adult females could result, at least partly, from behavioral and occupational factors.

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The association between short‐term exposure to air pollutants and rotavirus infection in Wuhan, China

Xing

Zhang

2021

Journal of Medical Virology

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Background The impact of various meteorological factors on rotavirus (RV) infection has been previously studied; however, few studies have explored the association between short‐term exposure to air pollutants and RV infection. Methods Daily RV positive cases among children aged 0–6 years were collected from July 2014 to August 2019 in Tongji hospital (Wuhan, China). Daily data on air temperature and air pollutants were obtained from the China Meteorological Network. A distributed lag model to explore the lagged effects of short‐term exposure to air pollutants and RV infection was performed. The distribution lag model was used to study the lag effect of short‐term exposure to air pollutants and RV infection. Results RV infection was negatively correlated with mean air temperature and O3 concentration. The RV infection risk decreased by 5.2% and 0.47% for every 1℃ increase in average temperature and 1 ug/m3 increase in O3 concentration, respectively. Increased PM2.5, SO2, and NO2 concentrations were independent risk factors for an increase in positive rates; their relative risk values were 1.0014 (95% confidence interval [CI], 1.0013–1.0015), 1.0050 (95% CI, 1.0047–1.0053), and 1.0030 (95% CI, 1.0028–1.0032), respectively. The highest RV‐positive rates were from January to March and November to December. Additionally, children <18 months of age and boys were more vulnerable to infection. Conclusions Air pollutants were important factors impacting the RV‐positivity of children in Wuhan. These findings may help develop an early environment‐based warning system to prevent and control RV infection.

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Prevalence and molecular typing of rotavirus in children with acute diarrhoea in Northeastern Colombia

Abstract: This is an open-access article distributed under the terms of the Creative Commons Attribution License.

Cited by 10 publications

References 34 publications

Wa-1 Equine-Like G3P[8] Rotavirus from a Child with Diarrhea in Colombia

Wa-1 Equine-Like G3P[8] Rotavirus from a Child with Diarrhea in Colombia

A Pooled Analysis of Sex Differences in Rotaviral Enteritis Incidence Rates in Three Countries Over Different Time Periods

The association between short‐term exposure to air pollutants and rotavirus infection in Wuhan, China

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