Potential role of zinc in the visceromegaly regression and recovery of hematological parameters during treatment of visceral leishmaniasis in children from an endemic area

Carbone, Débora Cardozo Bonfim; Zanoni, Lourdes Zélia; Cônsolo, Fernanda Zanoni; Sanches, Simone Camargo; Reis, Vanessa Quadros dos; Müller, Kirsten M.; Carvalho, Cristiano Marcelo Espínola; Silva, Maria Cláudia

doi:10.1590/s1678-9946201860050

Cited by 8 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Kala-azar patients reported low serum levels of vitamin A and zinc [31]. Improved clinical outcome of the disease was reported in children with kala-azar who received zinc supplementation along with amphotericin B or pentavalent antimonial treatment [32,33]. The serum levels of vitamin A, vitamin D, zinc, and iron improve the treatment outcomes in systemic leishmaniasis [34].…”

Section: Discussionmentioning

confidence: 99%

Mucosal Leishmaniasis Involving the Nostril and Maxillary Sinus: A Case Report

Bhowate¹,

Bhargava²,

Badki³

et al. 2022

Cureus

View full text Add to dashboard Cite

An eight-year-old child presented with nasal discharge, stuffiness, and whitish polypoid swelling in the left nostril with Bitot's spot. Computed tomography (CT) evaluation showed complete involvement of the left nostril and maxillary sinus. Blood investigations revealed leukocytosis, raised absolute eosinophils, increased alkaline phosphatase, and reduced vitamin A levels. Histopathological examination revealed inflammatory infiltrate with Leishman-Donovan bodies, which confirms the diagnosis of mucosal leishmaniasis (ML). In the present case, the recording of demographic data is important as the child was a migrant from the leishmaniasis-endemic area of Bihar state, India. Nasal polypoid growth was removed by endoscopic surgery, followed by a combination of allopathic and polyherbal preparation. The child responded well to these therapeutic measures, and there was no recurrence of nasal discharge, stuffiness, and crustation at six-month follow-up.

show abstract

Section: Discussionmentioning

confidence: 99%

Mucosal Leishmaniasis Involving the Nostril and Maxillary Sinus: A Case Report

Bhowate¹,

Bhargava²,

Badki³

et al. 2022

Cureus

View full text Add to dashboard Cite

show abstract

“…This finding is in line with those described in the literature 21 , 22 , 54 . Carbone et al 55 showed that children with kala-azar who received zinc supplementation during amphotericin B or pentavalent antimonial treatment showed faster clinical improvement than the group that did not receive zinc supplementation. However, a recent systematic review did not find any study that assessed the effects of oral nutritional supplements in patients with VL treated with antileishmanial drug therapy 56 .…”

Section: Discussionmentioning

confidence: 99%

Nutritional status and vitamin A and zinc levels in patients with kala-azar in Piauí, Brazil

Monteiro

Silva

Paiva

et al. 2021

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

INTRODUCTION: Malnutrition and kala-azar (or visceral leishmaniasis) are significant public health problems in different parts of the world. Immunity and susceptibility to infectious and parasitic diseases are directly linked to the host’s nutritional state, but little is known about the interaction between nutrition and kala-azar. This study aimed to evaluate nutritional status with kala-azar and correlate these findings with the clinical and laboratory manifestations of the disease, and zinc and retinol levels. METHODS: This was a cross-sectional study of 139 patients with kala-azar. Nutritional status classification was performed according to international recommendations. Parametric or nonparametric tests were applied whenever indicated in a two-sided test with a 5% significance level. RESULTS: Weight loss and malnutrition were more frequent in adults. Body mass index-for-age, fat area of the arm, and upper arm muscle area were significantly associated with probability of death. The presence of human immunodeficiency virus, hepatomegaly, and splenomegaly was correlated with nutritional assessment. Blood leukocyte and lymphocyte, serum creatine, and vitamin A levels were significantly higher in adult men. Vitamin A levels were highly associated with the level of hemoglobin and C-reactive protein (CRP) in multivariate analysis. All patients had reduced plasma zinc levels, but this finding had no association with the outcome variables. CONCLUSIONS: Malnutrition was correlated with severe disease and was more prevalent in older people with kala-azar. Vitamin A deficiency was associated with hemoglobin and CRP. Zinc levels were reduced in patients with kala-azar.

show abstract