Intestinal parasitism among waste pickers in Mato Grosso do Sul, Midwest Brazil

Júnior, Minoru German Higa; Cardoso, Wesley Márcio; Weis, Sabrina Moreira dos Santos; França, Adriana de Oliveira; Pontes, Elenir Rose Jardim Cury; Silva, Patrícia Vieira da; Oliveira, Márcia Pereira de; Dorval, Maria Elizabeth Moraes Cavalheiros

doi:10.1590/s1678-9946201759087

Cited by 5 publications

(4 citation statements)

References 19 publications

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“…40,41 In Brazil, the number of incidences of intestinal parasitosis related to serum eosinophils is scare, a study with 66 garbage collectors showed eosinophils >8% was 17% of the sample, and this number was not related to parasitosis. 42 We observed that this eosinophil group presented the higher mean value of 6MWD with the same lung function parameters to other groups. This can be associated to the lower rate of the previous exacerbation rate.…”

Section: Discussionsupporting

confidence: 58%

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<p>Different Clusters in Patients with Chronic Obstructive Pulmonary Disease (COPD): A Two-Center Study in Brazil</p>

Zucchi¹,

Franco²,

Schreck³

et al. 2020

COPD

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Background: Chronic obstructive pulmonary disease (COPD) has a functional definition. However, differences in clinical characteristics and systemic manifestations make COPD a heterogeneous disease and some manifestations have been associated with different risks of acute exacerbations, hospitalizations, and death. Objective: Therefore, the objective of the study was to evaluate possible clinical clusters in COPD at two study centers in Brazil and identify the associated exacerbation and mortality rate during 1 year of follow-up. Methods: We included patients with COPD and all underwent an evaluation composed of the Charlson Index, body mass index (BMI), current pharmacological treatment, smoking history (packs-year), history of exacerbations/hospitalizations in the last year, spirometry, six-minute walking test (6MWT), quality of life questionnaires, dyspnea, and hospital anxiety and depression scale. Blood samples were also collected for measurements of C-reactive protein (CRP), blood gases, laboratory analysis, and blood count. For the construction of the clusters, 13 continuous variables of clinical importance were considered: hematocrit, CRP, triglycerides, low density lipoprotein, absolute number of peripheral eosinophils, age, pulse oximetry, BMI, forced expiratory volume in the first second, dyspnea, 6MWD, total score of the Saint George Respiratory Questionnaire and packs-year of smoking. We used the Ward and K-means methods and determined the best silhouette value to identify similarities of individuals within the cluster (cohesion) in relation to the other clusters (separation). The number of clusters was determined by the heterogeneity values of the cluster, which in this case was determined as four clusters. Results: We evaluated 301 COPD patients and identified four different groups of COPD patients. The first cluster (203 patients) was characterized by fewer symptoms and lower functional severity of the disease, the second cluster by higher values of peripheral eosinophils, the third cluster by more systemic inflammation and the fourth cluster by greater obstructive severity and worse gas exchange. Cluster 2 had an average of 959±3 peripheral eosinophils, cluster 3 had a higher prevalence of nutritional depletion (46.1%), and cluster 4 had a higher BODE index. Regarding the associated comorbidities, we found that only obstructive sleep apnea syndrome and pulmonary thromboembolism were more prevalent in cluster 4. Almost 50% of all patients presented an exacerbation during 1 year of follow-up. However, it was higher in cluster 4, with 65% of all patients having at least one exacerbation. The mortality rate was statistically higher in cluster 4, with 26.9%, vs 9.6% in cluster 1. Conclusion: We could identify four clinical different clusters in these COPD populations, that were related to different clinical manifestations, comorbidities, exacerbation, and mortality rate. We also identified a specific cluster with higher values of peripheral eosinophils.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

<p>Different Clusters in Patients with Chronic Obstructive Pulmonary Disease (COPD): A Two-Center Study in Brazil</p>

Zucchi¹,

Franco²,

Schreck³

et al. 2020

COPD

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“…Giardia duodenalis infections followed distinctive gender- and age-related distribution patterns, being significantly more frequent in males than in females and children younger than ten years of age than in older subjects. The observed predominance of giardiasis in male subjects may be linked to unidentified behavioural or occupational habits [ 65 , 66 ]. Also, reporting of gastrointestinal symptoms was significantly higher in individuals with light to moderate Giardia infection burdens than in heavily infected individuals.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of intestinal parasites, with emphasis on the molecular epidemiology of Giardia duodenalis and Blastocystis sp., in the Paranaguá Bay, Brazil: a community survey

et al. 2018

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BackgroundIntestinal protozoan parasites are major contributors to the global burden of gastrointestinal disease causing significant socioeconomic consequences. Children living in resource-poor settings with restricted access to water and sanitary services are particularly at risk of these infections.MethodsA prospective, community-based, cross-sectional survey was conducted in Paraná (southern Brazil) between May 2015 and May 2016. A total of 766 stool samples were individually collected from volunteers (male/female ratio: 0.99; age range: 0–76 years) and used for investigating the presence of intestinal helminth and protozoan species by routine microscopic procedures including the Kato-Katz and modified Ritchie concentration methods and the Ziehl-Neelsen stain technique. Quantitative real-time PCR confirmed microscopy-positive samples for Giardia duodenalis and the assemblages and sub-assemblages determined by multilocus sequence-based genotyping of the glutamate dehydrogenase (gdh) and β-giardin (bg) genes of the parasite. Identification of Blastocystis subtypes was carried out by amplification and sequencing of a partial fragment of the small-subunit ribosomal RNA gene (SSU rDNA) of this heterokont microorganism.ResultsOverall, 46.1% (353/766) of the participants were infected/colonised by at least one intestinal parasite/commensal species. Protozoan and helminth species were detected in 42.7% and 10.1% of the surveyed population, respectively. Blastocystis sp. (28.2%), Endolimax nana (14.9%), and Giardia duodenalis (11.0%) were the most prevalent species found among protozoans and Ascaris lumbricoides (5.0%), Trichuris trichiura (4.6%) and hookworms (1.0%) among helminths. A total of 38 G. duodenalis-positive samples were genotyped at gdh and bg markers, revealing the presence of the sub-assemblages AII (47.4%), AII/AIII (2.6%), BIII (5.3%), BIV (26.3%) and BIII/BIV (13.1%). Two samples (5.3%) were only identified as assemblage B. AII was predominantly found in females aged 5–9 years and was associated with a higher likelihood of reporting gastrointestinal symptoms. A total of 102 Blastocystis-positive samples were successfully subtyped at the SSU rRNA gene revealing the presence of ST1 (36.3%), ST2 (15.7%), ST3 (41.2%), ST4 (2.9%), ST6 (1.0%) and ST8 (2.9%).ConclusionsData presented here indicate that enteric parasites still represent a pressing health concern in Paraná, Brazil, probably due to sub-optimal water, sanitation and hygiene conditions. A mostly anthroponotic origin is suspected for G. duodenalis and Blastocystis sp. infections.Electronic supplementary materialThe online version of this article (10.1186/s13071-018-3054-7) contains supplementary material, which is available to authorized users.

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“…Our systematic literature search yielded 1694 manuscripts using the established search strategies. As per the eligibility criteria (after exclusion of duplicate texts and articles related to other topics and exclusion of text based on review criteria or owing to method quality), 182 studies were selected for analysis ( Table 1 ) [ 2 – 4 , 6 , 7 , 9 – 25 , 27 – 37 , 39 , 40 , 42 – 45 , 47 – 56 , 58 , 60 – 63 , 65 – 69 , 71 , 72 , 74 , 75 , 77 – 83 , 85 – 93 , 95 – 104 , 106 – 109 , 111 , 114 – 123 , 125 – 130 , 132 , 135 , 136 , 138 – 140 , 142 – 146 , 148 – 150 , 153 – 164 , 167 , 169 – 173 , 175 – 192 , 194 – 204 , 207 – 210 , 212 – 215 , 217 – 219 ]. Of these studies, 166 evaluated the prevalence of Entamoeba spp.…”

Section: Resultsmentioning

confidence: 99%

Diversity, geographical distribution, and prevalence of Entamoeba spp. in Brazil: a systematic review and meta-analysis

Zanetti¹,

Malheiros²,

Matos³

et al. 2021

Parasite

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The genus Entamoeba includes a variety of widely distributed species adapted to live in the digestive tracts of humans and a large variety of animals of different classes. The objective of this study was to investigate the prevalence, distribution, and molecular epidemiology of Entamoeba spp. in different classes of hosts in Brazil. Studies that analyzed hosts from several classes, including humans and domestic, wild, or captive animals, were considered. The pooled prevalence of Entamoeba spp. was calculated using the random-effects model. A total of 166 studies on humans and 16 on animals were included. The prevalence of Entamoeba spp. in the Brazilian population was 22% (95% CI: 21–24). The state with the highest prevalence was Paraiba with 72%, followed by Federal District with 53%, and Rondonia with 50%. In immunocompromized patients, the prevalence was 18%, and cancer (36%) was the most prevalent cause of immunosuppression. The prevalence of Entamoeba spp. in animal hosts was 12% (95% CI: 7–17). Captive wild animals and domestic farm animals showed the highest prevalence, with 16% and 15%, respectively. The species found more often were E. coli (86.5%), E. dispar (7.9%), and E. histolytica (3.1%). In conclusion, a high prevalence (22%) of Entamoeba spp. was found in the Brazilian population, with a prevalence of up to 50% mainly in the northern, northeastern, and central-western regions. The pathogenic species E. histolytica is distributed in most Brazilian regions, with significant prevalence percentages. Among animals, unidentified Entamoeba species were most prevalent in mammals.

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Intestinal parasitism among waste pickers in Mato Grosso do Sul, Midwest Brazil

Cited by 5 publications

References 19 publications

<p>Different Clusters in Patients with Chronic Obstructive Pulmonary Disease (COPD): A Two-Center Study in Brazil</p>

<p>Different Clusters in Patients with Chronic Obstructive Pulmonary Disease (COPD): A Two-Center Study in Brazil</p>

Prevalence of intestinal parasites, with emphasis on the molecular epidemiology of Giardia duodenalis and Blastocystis sp., in the Paranaguá Bay, Brazil: a community survey

Diversity, geographical distribution, and prevalence of Entamoeba spp. in Brazil: a systematic review and meta-analysis

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