Prospective study of patients with persistent symptoms of dengue in Brazil

Abstract

Dengue is an arboviral infection clinically recognized as an acute and self-limited disease. Persistence of dengue symptoms is known, but it has been little studied. The aim of this study was to characterize persistent symptoms in 113 patients with dengue followed up clinically and by laboratory testing at a tertiary hospital. Symptoms that persisted for more than 14 days were observed in 61 (54.0%) patients, and six (6.2%) of them had symptoms for 6 months or more. The persistent symptoms identified were myalgia, weakness, hair loss, memory loss, reduced resistance to physical effort, headache, reasoning problems, arthralgia, sleepiness- and emotional lability. The progression to persistent symptoms was significantly associated with hospitalization, older age, more severe disease, the presence of bleeding and comorbidities upon univariate analysis. Upon multivariate analysis, the presence of persistent symptoms continued to be significantly associated only with increased age and dengue with warning signs. The platelet count during the acute phase of the disease was significantly lower in the group with persistent symptoms. In conclusion, the frequency of progression to persistent symptoms in dengue is relevant in patients seen at a tertiary hospital and the persistence of symptoms is more common in patients with dengue with warning signs.

Stegomyia Indices and Risk of Dengue Transmission: A Lack of Correlation

“…Dengue is one of the most widespread mosquito-borne arbovirus disease worldwide. Dengue viruses are present in 128 countries worldwide with major public health, social and economic consequences (1)(2)(3)(4)(5)(6)(7). Dengue is a complex disease with a wide spectrum of clinical symptoms, ranging from asymptomatic to fatal, which is often unrecognized or misdiagnosed and confused with other fever-causing tropical diseases (8).…”

A Incidência de Sífilis Congênita em Porto Nacional-TO No Período de 2016 a 2019

“…Fato confirmado por Quirino (2017), no qual o motivo para a não procura é afirmado pela falta de conhecimento sobre o TR, devido à baixa escolaridade e o nível socioeconômico.…”

The Uncertainty Surrounding the Burden of Post-acute Consequences of Dengue Infection

“…A range of post-acute consequences of dengue have been reported across different studies [3]. The most consistently reported included myalgia, weakness, headache, fever, and fatigue [3][4][5][6][7]. However, some of these symptoms, such as fever or headache, are quite common and are prevalent during an acute dengue episode.…”

“…The estimated proportion of patients experiencing post-acute consequences varies significantly across studies and tends to decrease over time after the acute illness [3,6]. Figure 2 illustrates the percentage of patients reporting dengue symptoms that may result in productivity losses (fatigue, asthenia, or trouble working) by elapsed follow-up time.…”

“…Abbreviations: YLDs: years of healthy life lost due to disability, YLLs: years of life lost due to premature death. of patients experiencing any fatigue or trouble working after recovery from dengue [6,8]. It was noteworthy that the time that the majority of studies followed up patients was short.…”