2017
DOI: 10.1590/s1678-9946201759005
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Abstract: Clinical and laboratory parameters including blood and cerebrospinal fluid (CSF) neopterin were investigated in human-T-lymphotropic-virus-type-I associated-myelopathy/tropical-spastic-paraparesis-HAM/TSP and in HTLV-I carriers. HAM/TSP (n = 11, 2 males/9 females, median age = 48 years), recently diagnosed HTLV-I carriers (n = 21, 15 females/6 males, median age = 44 years), healthy individuals (n = 20, 10 males/10 females, median age = 34.6 years) from the Brazilian Amazon (Manaus, Amazonas State) were investi… Show more

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Cited by 8 publications
(12 citation statements)
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“…Nonetheless, several studies suggest a higher prevalence and incidence in Brazil, in which an incidence density up to 5.3 cases per 1000 HTLV‐1 seropositive cases per year was detected . HAM/TSP cases have been described in many other countries (Table ) , most of them presenting a higher prevalence in people of African and mixed ancestry.…”
Section: Resultsmentioning
confidence: 99%
“…Nonetheless, several studies suggest a higher prevalence and incidence in Brazil, in which an incidence density up to 5.3 cases per 1000 HTLV‐1 seropositive cases per year was detected . HAM/TSP cases have been described in many other countries (Table ) , most of them presenting a higher prevalence in people of African and mixed ancestry.…”
Section: Resultsmentioning
confidence: 99%
“…O vírus linfotrópico T humano 1 (HTLV-1) é um retrovírus da família Retroviridae que afeta os linfócitos T do sangue humano e pode causar distúrbios neurológicos [1]. Acredita-se que existam atualmente 15 a 20 milhões de pessoas infectadas em todo o mundo [2,3] e vários países da América do Sul são frequentemente relatados com alta endemia, dentre eles, o Brasil [4,5], com a maior prevalência nas regiões Norte e Nordeste [6].…”
Section: Introductionunclassified
“…As células T CD4+ representam os principais reservatórios do vírus e são responsáveis pelo aumento da produção de citocinas inflamatórias, como IFN, TNFα e IL1 [2,7]. Esta resposta inflamatória ao HTLV-1, se perdurar, causará lesão no Sistema Nervoso Central e resultará na situação neuropatológica mais claramente relacionada à infecção viral crônica: a Paraparesia Espástica Tropical/Mielopatia associada ao HTLV-1 (PET/MAH) [2,7,8,9,10]. Assim, a PET/ MAH é considerada uma doença inflamatória crônica na qual o dano celular levou à desmielinização da medula espinhal [2,8,9].…”
Section: Introductionunclassified
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“…Approximately 0.25% to 3.8% of HTLV-1 carriers will develop HAM/TSP [ 5 , 6 ]. The predominant features of HAM/TSP are neurological; it evolves as a slow-progressing demyelinating disease of the central nervous system that manifests with gradual spastic paraparesis, neurogenic bladder, gait disturbances, and many mild sensory signs [ 7 ]. This condition predominantly affects female patients and is usually diagnosed at the age of 40 or 50, although, by the time of diagnosis, most patients had endured symptoms for over a decade [ 8 , 9 ].…”
Section: Introductionmentioning
confidence: 99%