2012
DOI: 10.1590/s1678-91992012000200005
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Abstract: Although sea anemones are well known for being rich sources of toxins, including cytolysins and neurotoxins, their venoms and toxins have been poorly studied. In the present study, the venoms from five sea anemones (Heteractis crispa, Heteractis magnifica, Heteractis malu, Cryptodendrum adhaesivum and Entacmaea quadricolor) were obtained by the milking technique, and the potential of these venoms to kill cancer cells was tested on three cell lines (A549 lung cancer, T47D breast cancer and A431 skin cancer). Th… Show more

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Cited by 19 publications
(10 citation statements)
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“…Soletti et al (2008) demonstrated that two sea anemone cytolysins, toxin Bc2 and EqTx-II, induced cytotoxicity against U87 and A172 human glioblastoma cell lines. There have only been a small number of studies on the cytotoxicity of venom from anemone on cancer cells (Soletti et al 2008;Ramezanpour et al 2012). However, the mechanisms underlying any cytotoxic effects of sea anemone venom on cancer cells have not been elucidated.…”
Section: Introductionmentioning
confidence: 99%
“…Soletti et al (2008) demonstrated that two sea anemone cytolysins, toxin Bc2 and EqTx-II, induced cytotoxicity against U87 and A172 human glioblastoma cell lines. There have only been a small number of studies on the cytotoxicity of venom from anemone on cancer cells (Soletti et al 2008;Ramezanpour et al 2012). However, the mechanisms underlying any cytotoxic effects of sea anemone venom on cancer cells have not been elucidated.…”
Section: Introductionmentioning
confidence: 99%
“…Crystal violet stains the DNA of the live cells that adheres the plate after the dead cells are washed away [18]. The relative number of viable cells was determined using crystal violet assay (CV) as described in [19]. Briefly, 50 µL of crystal violet stain (0.5% of crystal violet in 50% methanol) was added to each well and incubated for 10 minutes at ambient temperature.…”
Section: Crystal Violet Assaymentioning
confidence: 99%
“…The relative number of viable cells was determined using crystal violet assay (CV) as described in [21]. Briefly, 50 μL of crystal violet stain (0.5% of crystal violet in 50% methanol) was added to each well and incubated for 10 minutes at ambient temperature.…”
Section: Crystal Violet Assaymentioning
confidence: 99%