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doi:10.1590/s1678-91992011000400007

Cited by 15 publications

(10 citation statements)

References 17 publications

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“…Methanol extracts of Cymbopogan citratus, Andrographis paniculata, Momordica charantia, Ocimum sanctum, Pelargonium citrosum, and Citrus limon showed inhibitory effects on DENV type-1 (DENV-1) growth in Vero E6 cells with A. paniculata exhibiting the highest activity followed by M. charantia [50]. Similar findings were also reported in ethanol and aqueous extracts of A. paniculata leaves [84,85]. The ethanol extract possessed higher inhibitory potential (75%), attributable to the presence of polyphenols and terpenes [88].…”

Section: In Vitro Studiessupporting

confidence: 67%

“…Reduction in cytopathic effect-structural changes in host cell due to viral invasionis the major technique used for the detection of the extract's inhibitory capacity against DENV. Polar extracts such as aqueous [36,81,84], methanol [50,[84][85][86], and ethanol [87,88] have been reported to possess anti-dengue activity. The inhibitory potential is attributable to the presence of polyphenols and terpenes [88].…”

Section: In Vitro Studiesmentioning

confidence: 99%

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Potential Medicinal Plants for the Treatment of Dengue Fever and Severe Acute Respiratory Syndrome-Coronavirus

Saleh

Kamisah

2020

Biomolecules

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While dengue virus (DENV) infection imposes a serious challenge to the survival of humans worldwide, severe acute respiratory syndrome-coronavirus (SARS-CoV) remains the most devastating pandemic in human history. A significant number of studies have shown that plant-derived substances could serve as potential candidates for the development of safe and efficacious remedies for combating these diseases. Different scientific databases were used to source for literature on plants used against these infections. Thirty-five studies described the traditional use of 25 species from 20 families for treating DENV infection with Carica papaya and Euphorbia hirta were the most widely used across different regions. 13 in vivo studies, 32 in vitro studies, and eight clinical studies were conducted on 30 species from 25 families against different DENV serotypes, while plants from 13 families were reported to inhibit different forms of SARS-CoV, all of which were investigated through in vitro studies. Phytoconstituents belonging to various chemical classes were identified to show a wide range of antiviral activity against these infections. Extensive studies on the potentials of medicinal plants are needed to confirm their efficacy. This paper reveals the capabilities of medicinal plants and their phytochemicals in inhibiting DENV and SARS-CoV infections.

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Section: In Vitro Studiessupporting

confidence: 67%

Section: In Vitro Studiesmentioning

confidence: 99%

Potential Medicinal Plants for the Treatment of Dengue Fever and Severe Acute Respiratory Syndrome-Coronavirus

Saleh

Kamisah

2020

Biomolecules

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“…Separation was performed with a linear gradient as previously described, with some modifications (Silva et al, 2011). Acetonitrile (C) and Milli-Q water (pH 2.8) (D) were used as the mobile phases with the following gradient elution programme: 0-15 min, isocratic elution with C:D (20:80 v/v); 17-25 min, linear change to C:D (40:60 v/v); and 25-40 min, isocratic elution with C:D (20:80 v/v).…”

Section: High-performance Liquid Chromatographymentioning

confidence: 99%

Chemical constituents of Calotropis procera latex and ultrastructural effects on Haemonchus contortus

Cavalcante

Morais

André

et al. 2020

Rev. Bras. Parasitol. Vet.

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This study aimed to evaluate the anthelmintic and ultrastructural effects of Calotropis procera latex on Haemonchus contortus. C. procera latex was twice centrifuged at 10,000×g and dialyzed to obtain a fraction rich in proteins, named LP (latex protein), and at 3,000 rpm to obtain a fraction rich in secondary metabolites, named LNP (latex non-protein). Specimens of H. contortus exposed to LNP, LP and PBS in the Adult Worm Motility Test (AWMT) were submitted to scanning (SEM) and transmission (TEM) electron microscopy to verify changes in their ultrastructure. Phytochemical tests in the LNP indicated the presence of phenols, steroids, alkaloids and cardenolides. High-Performance Liquid Chromatography (HPLC) characterized the presence of the compounds gallic acid and quercetin in the LNP. The protein content in the LP was 43.1 ± 1.1 mg/mL and 7.7 ± 0.3 mg/mL in LNP. In AWMT, LNP and LP inhibited the motility of 100% of the nematodes, with LNP being more effective than LP and ivermectin more effective than both (p <0.05). Cuticle changes were observed by SEM and TEM in nematodes treated with LP and LNP. Calotropis procera latex has anthelmintic effects against H. contortus, causing damage to its cuticle and other alterations in its ultrastructure.

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“…Em análises por Cromatógrafo Líquido Ultra Rápido encontraram a presença de ácido gálico, clorogênico (8,5 µg.g -1 de polpa) foi o majoritário, protocatecóico, pcumárico, vanílico e ferrulíco, os quais possuem propriedades terapêuticas. No estudo do extrato das folhas do umbuzeiro (S. tuberosa) apresentou a presença de ácido elágico, flavonóis, quercetina e rutina os quais desempenham atividade antiviral contra o vírus da dengue tipo 2 (Silva, 2011).…”

Section: Introductionunclassified

Licor funcional a base de umbu (Spondias tuberosa Arruda) e microalga (Spirulina spp.)

Neto

Santos

Cunha

et al. 2021

RSD

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O umbu é uma fonte vegetal muito importante para a Caatinga, por possuir compostos importante para alimentação. A microalga Spirulina spp. tem uso como suplemento alimentar funcional. No presente estudo, objetivou-se elaborar e avaliar as características físico-químicas dos licores das folhas e dos frutos de umbu, acrescidos de microalga Spirulina spp., obtidos no Instituto Federal de Alagoas, localizado no município de Piranhas - AL. Foram elaboradas quatro formulações de licor da folha do umbu e quatro formulações de licor da polpa do umbu, adicionados de microalga Spirulina spp. Em seguida, foi realizada a caracterização física de 20 amostras de frutos através das medidas de massa dos frutos, comprimento, diâmetro, densidade e rendimento da polpa. Para a caracterização físico-química dos licores, foram realizadas as análises de pH, acidez total titulável, sólidos solúveis, umidade e cinzas. Os licores das folhas de umbu e polpa de umbu apresentaram os teores médios de pH entre 2,93 a 3,01, respectivamente. Entre as formulações, podemos perceber que a umidade foi elevada, ficando acima de 90%. A partir destes resultados, observou-se a capacidade destes licores no processamento agroindustrial, pois possuem elevados rendimentos. E que a inclusão de microalga (Spirulina spp.) potencializa o valor nutricional do licor.

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Cited by 15 publications

References 17 publications

Potential Medicinal Plants for the Treatment of Dengue Fever and Severe Acute Respiratory Syndrome-Coronavirus

Potential Medicinal Plants for the Treatment of Dengue Fever and Severe Acute Respiratory Syndrome-Coronavirus

Chemical constituents of Calotropis procera latex and ultrastructural effects on Haemonchus contortus

Licor funcional a base de umbu (Spondias tuberosa Arruda) e microalga (Spirulina spp.)

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