Neutralization of pharmacological and toxic activities of Bothrops jararacussu snake venom and isolated myotoxins by Serjania erecta methanolic extract and its fractions

Fernandes, RS; Costa, T. R.; Marcussi, Silvana; Bernardes, C.; Menaldo, Danilo L.; Gonzaléz, II Rodriguéz; Pereira, Paulo Sérgio; Soares, A.M.

doi:10.1590/s1678-91992011000100011

Cited by 16 publications

(7 citation statements)

References 41 publications

(45 reference statements)

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“…Reactive oxygen species are involved in the pathogenesis of gastric lesions, , and antioxidants play an important role in protecting against such damage. It has been shown that rutin at a dose of 200 mg kg –1 showed a gastroprotective effect against 50% ethanol-induced ulcers, and this effect may be related to the antioxidant properties, since rutin was able to decrease the levels of lipoperoxide and increase the antioxidant activity of the enzyme GSH-Px .…”

Section: Results and Discussionmentioning

confidence: 99%

Unusual C,O-Fused Glycosylapigenins from Serjania marginata Leaves

et al. 2014

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A phytochemical study of a Serjania marginata leaf extract with antiulcer activity afforded 15 compounds, including the new 3-O-α-l-arabinopyranosyl(1→3)-α-l-rhamnopyranosyl(1→2)[β-d-glucopyranosyl(1→4)]-α-l-arabinopyranosyloleanolic acid (1) and 7,5″-anhydroapigenin 8-C-α-(2,6-dideoxy-5-hydroxy-ribo-hexopyranosyl)-4'-O-β-d-glucopyranoside (4). The structures of the new compounds were determined by spectroscopic analysis, including 1D and 2D NMR techniques, mass spectrometry, and chemical methods. Compound 4 is a C-hexopyranosylapigenin with an unusual cyclic ether linkage between C-5″ and C-7 of apigenin. The isolated proanthocyanidins have high antioxidant activities, and these compounds are probably responsible for the gastroprotective effect of the extract.

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Section: Results and Discussionmentioning

confidence: 99%

Unusual C,O-Fused Glycosylapigenins from Serjania marginata Leaves

et al. 2014

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“… 24 Its is alreay proved that the methanolic extract and fractions of Serjania erecta rich in flavonoids and tannins exhibited as powerful inhibitors of the hemorrhagic and clotting activity, possibly due to interaction with metalloproteases and thrombin-like enzymes. 25 Studies of several plants ( Heliconia curtispatha , Pleopeltis percussa , Brownea rosademonte , Bixa orellana (紅木 hóng mù), Trichomanes elegans , Struthanthus orbiculareis and Casearia sylvestris (林生腳骨脆 lín shēng jiǎo gǔ cuì) describe the inhibitory effect of all or part of the coagulant activity of snake venoms from B. asper , B. jararacussu , B. pirajai , B. neuwiedi , B. moojeni and C. d. terrificus . 26 , 27 , 28 The present study documents 38 species of ethnomedicinal plants from 25 families used by the tribal healers and medical practitioners in non-tribal communities.…”

Section: Discussionmentioning

confidence: 99%

A randomized ethnomedicinal survey of snakebite treatment in southwestern parts of Bangladesh

Hasan

Azam²,

Ahmed³

et al. 2016

Journal of Traditional and Complementary Medicine

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Snakebite is the single most important toxin-related injury, causing substantial mortality in many parts of the Africa, Asia and the Americas. Incidence of snakebite is usually recorded in young people engaged in active physical work in rural areas. The various plant parts used to treat snakebite included whole plant, leaves, barks, roots and seeds. Most bites in Bangladesh are recorded between May and October with highest number in June. Lower and upper limbs are most common sites of snakebite, but it may happen in other sites as well. Snake venom (蛇毒 shé dú) has been the cause of innumerable deaths worldwide. However, antiserum does not provide enough protection against venom induced hemorrhage, necrosis, nephrotoxicity and hypersensitivity reactions. Informed consent was obtained from the practitioners prior to interviews. After the survey, it is concluded that the medicinal plants used by tribal medicinal practitioners in Bangladesh for treatment against snakebite are Acyranthes aspera L. (土牛膝 tǔ niú xī), Amaranthus Viridis L. (野莧菜 yě xiàng cài), Asparagus racemosus Willd (總序天冬 zǒng xù tiān dōng) and Emblica officinalis Gaertn (油柑 yóu gān), while the non-tribal communities used 35 plant species among them, most of the plants reported as new species used against snakebite in the belonging family. The plants present a considerable potential for discovery of novel compounds with fewer side effects for treatment of antisnake venom and can, at least in Bangladesh, become a source of affordable and more easily available drugs.

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“…Further investigations reveal that extracts from plants and their antioxidant components can neutralize the myotoxic effects induced by certain toxins such as BthTx-II [51,52]. This enzyme is known to causes evident muscle tissue damage characterized by distinct ultra-structural modifications, which can be measured through the CK levels.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Thiol-dependent Enzymes on the Pharmacological Effects Induced by the Catalytically Active PLA2 from Bothrops jararacussu

Toyama¹,

Crc²,

Mn³

et al. 2021

Preprint

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Background: Clinical cases reports with snake accidents show that venom bite induces increased oxidative stress including several markers of lipid peroxidation and other oxidative stress marker in plasma. Methods: The main findings of this work were performed with BthTx-II on paw edema of animals treated with the toxin and biochemical measurement of COX-2, PGE2, MDA and the effects of peroxiredoxin inhibitors on edema and myotoxicity were also evaluated. Results: The results show that edema and myotoxocity induced by PLA2 (BthTx-II) induces a strong mobilization of arachidonic acid and an increase in cellular oxidative stress as measured by increased malondialdehydo (MDA) concentration and protein carbonylation. Thus, these findings establish the strong link between oxidative stress, arachidonic acid mobilization and that these events may explain the presence of oxidative stress markers in snake-bitten patients. Experiments performed with animals previously treated with commercially purchased inhibitors showed enzymes such as thioredoxin (TXN), thioredoxin reductase (TXNRD) and other glutathione (GSH)-related antioxidant defenses could play an essential role controlling and defining the end of edema on the late phase of PLA2 BthTx-II-induced process. Conclusion. This study showed that thioate-dependent antioxidant enzymes play an important role in resolving the edema induced by BthTx-II.

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Neutralization of pharmacological and toxic activities of Bothrops jararacussu snake venom and isolated myotoxins by Serjania erecta methanolic extract and its fractions

Cited by 16 publications

References 41 publications

Unusual C,O-Fused Glycosylapigenins from Serjania marginata Leaves

Unusual C,O-Fused Glycosylapigenins from Serjania marginata Leaves

A randomized ethnomedicinal survey of snakebite treatment in southwestern parts of Bangladesh

Evaluation of Thiol-dependent Enzymes on the Pharmacological Effects Induced by the Catalytically Active PLA2 from Bothrops jararacussu

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