2010
DOI: 10.1590/s1678-91992010000200012
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Abstract: Snakebites comprise a serious health problem in several countries due to their global incidence, which exceeds 2.5 million per year, and the elevated number of victim fatalities. To counteract envenomations, antivenoms have been used regularly for more than a century. Apart from side effects including anaphylactic reactions, antivenoms are not able to efficiently neutralize local tissue damage, which contributes to increasing the severity and morbidity observed in patients. This fact, in turn, may be responsib… Show more

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Cited by 25 publications
(12 citation statements)
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“…Low mortality rate of S. adstringens and L. pacari extracts can be attributed to a different composition that is seasonal and geographic dependent (Santos et al 2010). Both extracts have been related with insecticidal activities (Mazzonetto & Vendramim 2003, Rogério et al 2008, but mostly, they have been reported with high presence of anti--inflammatory and anti-oxidant compounds, where substances such as tannins (Porfírio et al 2009, Silva Júnior et al 2010, De Paula et al 2010. Further studies must be done to verify the potential in vivo activity, once botanical fractions and bioproducts are preferred for their economic benefits, low environmental persistence, lack of resistance in arthropods and relative non-toxicity to animals (Du et al 2008).…”
Section: Discussionmentioning
confidence: 99%
“…Low mortality rate of S. adstringens and L. pacari extracts can be attributed to a different composition that is seasonal and geographic dependent (Santos et al 2010). Both extracts have been related with insecticidal activities (Mazzonetto & Vendramim 2003, Rogério et al 2008, but mostly, they have been reported with high presence of anti--inflammatory and anti-oxidant compounds, where substances such as tannins (Porfírio et al 2009, Silva Júnior et al 2010, De Paula et al 2010. Further studies must be done to verify the potential in vivo activity, once botanical fractions and bioproducts are preferred for their economic benefits, low environmental persistence, lack of resistance in arthropods and relative non-toxicity to animals (Du et al 2008).…”
Section: Discussionmentioning
confidence: 99%
“…Most often, the available anti-dote depends on the effect of known plants comprising of different parts such as leaves, stem, roots, tubers and seeds etc. as antidote (Agoro, 1978;Hati et al, 1992;Biondo et al, 2003;Ambikapathi et al, 2009;Paula et al, 2010 andAmui et al, 2011). In rural area, several medicinal plants are most commonly being used by traditional healers as a source valid medicine for venomous snake bite such as Datura metel, Rubia chordifolia, Embelia ribes, Glyceria glabra etc (Houghton and Osibogun, 1993;Soars et al, 2004;Marcussi et al, 2007).…”
Section: Introductionmentioning
confidence: 99%
“…However, in most cases, scientific evidence of their antiophidian activity is still needed. Several plants have already shown antiophidian activity and the Brazilian flora has a wide variety of medicinal plants with antisnake-venom potential (2,3,5,6,11).…”
Section: Introductionmentioning
confidence: 99%