Some arachnidan peptides with potential medical application

Lima, M.E. de; Borges, Márcia Helena; Verano‐Braga, Thiago; Torres, Fernanda Silva; Montandon, Gabriela; Cardoso, Fernanda C.; Peixoto, K. D. B. A.; Cardoso-Jr, H. C.; Benelli, M. T.

doi:10.1590/s1678-91992010000100004

Cited by 8 publications

(3 citation statements)

References 52 publications

(67 reference statements)

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“…Accidents by Phoneutria species cause local pain that may radiate, edema, erythema, paresthesia (burning, numbness, itching), sweating near the site of the bite, hypothermia, tachypnea, bradypnea, blurred vision, pallor, cyanosis, prostarion, generalized muscle fasciculation (involuntary muscle contraction), vomiting, cardiac arrhythmia, tachycardia, poor peripheral perfusion, elevated blood pressure, and, depending on severity, may progress to death 7,8,21,22,23,24 . In many cases, the victim may not notice the bite or chooses not to seek treatment through negligence or difficulties of access to health care facilities.…”

Section: Case Report | Relato De Casomentioning

confidence: 99%

Brazilian wandering spider accident with sequela of Raynaud phenomenon

Salvatierra

Ramos

2018

Revista Pan-Amazônica de Saúde

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INTRODUCTION: Mild symptoms of envenoming by Phoneutria spiders are local pain, erythema, and edema. Systemic manifestations are uncommon and sequelae have been rarely reported in literature. OBJECTIVE: To describe the case of a young woman bitten by a Phoneutria spider on middle toe of left foot. CASE REPORT: The evaluation was described as a case of moderate complication with Raynaud phenomenon sequelae. The bite site became darker and pain, swelling, and cold sensation persisted for several days along with numbness and desquamation. The clinical examination of the patient also indicated poor circulation on middle toe. After four months from the accident, the wound healed, but the patient experienced persistent pain, which radiated to plantar area, and insistent abnormal blood flow (Raynaud phenomenon) as sequelae. CONCLUSION: This study brings light to sequelae of phoneutrism rarely reported in literature.

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Section: Case Report | Relato De Casomentioning

confidence: 99%

Brazilian wandering spider accident with sequela of Raynaud phenomenon

Salvatierra

Ramos

2018

Revista Pan-Amazônica de Saúde

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“…Experimental studies have shown that the venom causes an activation of voltage-dependent sodium channels, and a blockade of voltage-dependent potassium and calcium channels in muscle fibers and sensory nerve endings in both the motor and autonomic nervous systems. As a consequence, there is a release of neurotransmitters, especially acetylcholine and catecholamines, which explains the following symptoms: severe pain at the bite site, sweating, agitation, salivation and, in severe cases, arrhythmias and priapism [ 75 , 77 , 78 ].…”

Section: Reviewmentioning

confidence: 99%

Arachnids of medical importance in Brazil: main active compounds present in scorpion and spider venoms and tick saliva

Cordeiro¹,

Amorim²,

Anjolette³

et al. 2015

J Venom Anim Toxins Incl Trop Dis

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Arachnida is the largest class among the arthropods, constituting over 60,000 described species (spiders, mites, ticks, scorpions, palpigrades, pseudoscorpions, solpugids and harvestmen). Many accidents are caused by arachnids, especially spiders and scorpions, while some diseases can be transmitted by mites and ticks. These animals are widely dispersed in urban centers due to the large availability of shelter and food, increasing the incidence of accidents. Several protein and non-protein compounds present in the venom and saliva of these animals are responsible for symptoms observed in envenoming, exhibiting neurotoxic, dermonecrotic and hemorrhagic activities. The phylogenomic analysis from the complementary DNA of single-copy nuclear protein-coding genes shows that these animals share some common protein families known as neurotoxins, defensins, hyaluronidase, antimicrobial peptides, phospholipases and proteinases. This indicates that the venoms from these animals may present components with functional and structural similarities. Therefore, we described in this review the main components present in spider and scorpion venom as well as in tick saliva, since they have similar components. These three arachnids are responsible for many accidents of medical relevance in Brazil. Additionally, this study shows potential biotechnological applications of some components with important biological activities, which may motivate the conducting of further research studies on their action mechanisms.

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“…In relation to peptides, toxin PnTx4-3, isolated from venom of the spider Phoneutria nigriventer , interacts with glutamatergic neurotransmission [ 29 – 31 ]. Assays performed using rat brain synaptosomes revealed a dose-dependent inhibition of glutamate uptake; however, action studies in animal models for neurological disorders, focused on evaluating the neuroprotective effect have not yet been completed [ 30 ].…”

Section: Reviewmentioning

confidence: 99%

Neuroactive compounds obtained from arthropod venoms as new therapeutic platforms for the treatment of neurological disorders

Monge-Fuentes¹,

Gomes²,

Campos³

et al. 2015

J Venom Anim Toxins Incl Trop Dis

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The impact of neurological disorders in society is growing with alarming estimations for an incidence increase in the next decades. These disorders are generally chronic and can affect individuals early during productive life, imposing real limitations on the performance of their social roles. Patients can have their independence, autonomy, freedom, self-image, and self-confidence affected. In spite of their availability, drugs for the treatment of these disorders are commonly associated with side effects, which can vary in frequency and severity. Currently, no effective cure is known. Nowadays, the biopharmaceutical research community widely recognizes arthropod venoms as a rich source of bioactive compounds, providing a plethora of possibilities for the discovery of new neuroactive compounds, opening up novel and attractive opportunities in this field. Several identified molecules with a neuropharmacological profile can act in the central nervous system on different neuronal targets, rendering them useful tools for the study of neurological disorders. In this context, this review aims to describe the current main compounds extracted from arthropod venoms for the treatment of five major existing neurological disorders: stroke, Alzheimer’s disease, epilepsy, Parkinson’s disease, and pathological anxiety.

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Some arachnidan peptides with potential medical application

Cited by 8 publications

References 52 publications

Brazilian wandering spider accident with sequela of Raynaud phenomenon

Brazilian wandering spider accident with sequela of Raynaud phenomenon

Arachnids of medical importance in Brazil: main active compounds present in scorpion and spider venoms and tick saliva

Neuroactive compounds obtained from arthropod venoms as new therapeutic platforms for the treatment of neurological disorders

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