2008
DOI: 10.1590/s1678-91992008000300004
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Abstract: ABSTRACT:The present study aimed to assess the effects of low-level laser (660 nm) on myonecrosis caused by the insertion of Bothrops neuwiedi venom in the gastrocnemius muscle of rats. Male Wistar rats were divided into three groups (n = 24 each): Group S (0.9% saline solution); Group V (venom) and Group VLLL (venom plus low-level laser). These categories were subdivided into four additional groups (n = 6) based on the euthanasia timing (3 hours, 24 hours, 3 days and 7 days). The groups V and VLLL were inocul… Show more

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Cited by 5 publications
(6 citation statements)
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“…Recently, we demonstrated that myonecrosis induced by B. jararacussu crude venom was diminished by laser treatment (25). Similar results were found by Dourado et al (27,28) when studying myonecrosis provoked by Bothrops moojeni and Bothrops neuwiedi venoms and treated with LLLT. They suggested that laser treatment is able to block the ability of venom to disrupt the plasma membrane integrity.…”
Section: Discussionsupporting
confidence: 80%
See 1 more Smart Citation
“…Recently, we demonstrated that myonecrosis induced by B. jararacussu crude venom was diminished by laser treatment (25). Similar results were found by Dourado et al (27,28) when studying myonecrosis provoked by Bothrops moojeni and Bothrops neuwiedi venoms and treated with LLLT. They suggested that laser treatment is able to block the ability of venom to disrupt the plasma membrane integrity.…”
Section: Discussionsupporting
confidence: 80%
“…The optical laser power was determined by a Newport 1835-C Multi Function Optical Power Meter® (Newport Corp., USA). Laser dose was low enough to avoid any thermal effect and chosen based on studies that had shown a beneficial effect of low-level laser therapy on the inflammatory process and myonecrotic effect (24,(27)(28)(29).…”
Section: Laser Devicementioning
confidence: 99%
“…Even under the anesthesia, after venom injection, pain was observed manifestating in all the G1 and G2 animals. There was muscle fasciculation in the right hind limb, which stayed flexed for about 20 h. Same demonstration was also observed by Dourado et al (2008) in mice inoculated with B. neuwiedi venom for 12 h. In the present study, the peak of hyperalgesia was observed after one hour after venom inoculation and clinical signs of pain gradually decreased and disappeared completely after 24 h. The pharmacological basis of hyperalgesia and allodynia induced by the bothropic venom has been investigated and the involvement of various mediators, such as bradykinin and leucotrienes has shown a multifactorial mechanism in the onset of pain (Chacur et al 2001). This effect can be potentialized by increased local pressure caused by edema.…”
Section: Resultssupporting
confidence: 83%
“…Due to the relevance of local effects in envenomation induced by the snakes of the genus Bothrops, several studies have been made on its different perspectives (Dourado et al 2008). The use of phytotherapy against the snake venom has long been recognized, even in modern times but only for the last 20 years, it gained closer scientific attention (Mors et al 2000).…”
Section: Introductionmentioning
confidence: 99%
“…The most LLLT used in in vivo and in vitro studies are helium-neon (HeNe), gallium arsenide (GaAs), gallium arsenide aluminum (AsGal), and Indio-gallium-aluminum-phosphide (IngGaAlP), and the wavelength ranges from 660 to 830 nm [10][11][12][13]. However, to date, only few studies investigated the effects of GaAs laser on skeletal muscle regeneration, with some studies showing positive results [7,[14][15][16], but not all [17]. Moreover, these studies used different irradiation parameters (e.g., final energy) and periods of treatment (e.g., very long 21 days, or very short 3 h up to 5 days) after injury, making it difficult to establish a consensus regarding the best application duration of GaAs laser.…”
Section: Introductionmentioning
confidence: 99%