Anti-inflammatory activity of the apolar extract from the seaweed Galaxaura marginata (Rhodophyta, Nemaliales)

Rozas, Enrique E.; Freitas, José Carlos de

doi:10.1590/s1678-91992007000200011

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…Ethanol:acetic acid extract (1mg/ear) of Galerina marginata was reported to cause 95±0.5% reduction of mouse ear edema with its 4 Hexane-thin layer chromatography (TLC) fractions inhibited 55, 75, 100, and 100%. EC 50 of ethanol:acetic extract was reached at 0.31mg/ear and its anti-inflammatory activity was associated to inhibition of PLA 2 (Rozas and Freitas, 2007).…”

Section: Ethanol Extractmentioning

confidence: 95%

Anti-inflammatory compounds of macro algae origin: A review

Jaswir¹

2011

J. Med. Plants Res.

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Inflammation, occurs frequently in living tissues, and is responsible for numerous death and precursor to some deadly diseases. This review focus on seaweed derived anti-inflammatory compounds, which have attracted interest and promising replacer of current anti-inflammatory drugs. Macro algae have both pro-and anti-inflammatory compounds, the later include sulphated polysaccharides (fucoidans) from brown seaweeds, alkaloids (Caulerpin I, II and III) from red and green seaweeds, polyunsaturated fatty acids (Docosahexaenoic acid: EDA, Eicosapentaenoic acid: EPA, Stearidonic acid: SA and Eicosatrienoic acid: ETA), carotenoids (fucoxanthin and astaxanthin), Pheophytin A and Vidalols A and B. Anti-inflammatory assays include edema, erythema, tumor necrosis factor (TNF-α), interleukin (IL 1β, 6, 8), Nitric oxide (NO), inducible Nitric oxide synthase (iNOS), Prostaglandin E (PGE 2 and 3), Cyclooxygenase (COX-2), transcription factor (NF-κB) and leukotrienes (LB 3 and 4). Although, in-vivo and in-vitro studies have been done for crude extracts and specific compounds, but some compounds have not analysed in-vitro, and investigation of their pathway need to be studied.

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Section: Ethanol Extractmentioning

confidence: 95%

Anti-inflammatory compounds of macro algae origin: A review

Jaswir¹

2011

J. Med. Plants Res.

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Taxonomy of Marine Macroalgae Used as Sources of Bioactive Compounds

Rindi

Soler-Vila

Guiry

2011

Marine Bioactive Compounds

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Anti-inflammatory, Antioxidant, Lung and Liver Protective Activity of Galaxaura oblongata as Antagonistic Efficacy against LPS using Hematological Parameters and Immunohistochemistry as Biomarkers

Nabil-Adam

Shreadah

2022

CHAMC

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Background: This study aimed to investigate the potential bioactivity and the ameliorative role of Galaxaura oblongata (G. oblongata) against LPS-induced toxicity by using hematological parameters. Objective: It is aimed also to examine its protective effect using the immunohistochemistry of liver and lungs as biomarkers in male BALB/C albino mice. Materials and Methods: the current study carried out using different in-vitro and in-vivo assays such as phytochemical, antioxidants, anti-inflammatory for in-vitro where the hematological and immunohistochemistry for lung and liver were investigated in vivo. Results: There are no previous studies were performed to investigate the in vivo and in vitro effects of the G. oblongata extracts as antioxidant and anti-inflammatory due to their rareness compared to other red algae. LPS treated mice revealed a significant decrease in total number of WBCs, RBCs, platelets, and HGB%, MPV, MCV and MCHC compared to the control group. On contrast, the HCT and MCHC were increased in the induction group which was treated with LPS compared to the control group. Furthermore, the immunohistochemistry results of the present study revealed the protective effect of G. oblongata compared to the induction group. G. oblongata can be used as protective marine natural products against the toxicity induced by LPS. Conclusion: It exhibited a significant ameliorative role against the alterations in the hematological parameters and immunohistochemistry of liver and lungs, and helps to reduce as well as coordinate the acute inflammations caused by TNF.

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Anti-inflammatory activity of the apolar extract from the seaweed Galaxaura marginata (Rhodophyta, Nemaliales)

Cited by 3 publications

References 9 publications

Anti-inflammatory compounds of macro algae origin: A review

Anti-inflammatory compounds of macro algae origin: A review

Taxonomy of Marine Macroalgae Used as Sources of Bioactive Compounds

Anti-inflammatory, Antioxidant, Lung and Liver Protective Activity of Galaxaura oblongata as Antagonistic Efficacy against LPS using Hematological Parameters and Immunohistochemistry as Biomarkers

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