2007
DOI: 10.1590/s1678-91992007000200004
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Abstract: Due to the development of antibiotic resistance in microorganisms, antimicrobial peptides from natural sources have attracted attention in recent times. Several antimicrobial peptides have been isolated from a wide range of animal sources, particularly snake venoms. Naja naja venom showed antibacterial as well as direct and indirect hemolytic activities, and an antibacterial peptide was purified through gel permeation and ion exchange chromatography. Its molecular mass was 2491Da, which was determined using Ma… Show more

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Cited by 13 publications
(5 citation statements)
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References 27 publications
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“…Plates were incubated at 37 ∘ C for 24 h with continuous shaking. Percentage inhibition was calculated according to Sachidananda et al as follows [22]:…”
Section: Mnps Inhibitory Potentials and Growth Kineticsmentioning
confidence: 99%
“…Plates were incubated at 37 ∘ C for 24 h with continuous shaking. Percentage inhibition was calculated according to Sachidananda et al as follows [22]:…”
Section: Mnps Inhibitory Potentials and Growth Kineticsmentioning
confidence: 99%
“…Strong bactericidal effects against Gram-positive bacteria are shown for a rattlesnake PLA 2 [66], with similar activity against S. aureus reported for a basic PLA 2 [68], a myotoxic PLA 2 from B. neuwiedi pauloensis venom [90], PLA 2 s from Bothrops venom [91][92], and a myotoxic Lys49 PLA 2 from the venom of B. asper [77]. More recently, small peptides from Naja naja venom display higher inhibitory activity against S. aureus [93]. Another study, cardiotoxin 3 (N. naja atra) and toxin Y (N. nigricolliss) showed potent inhibitory activity for the growth of S. aureus [54,55].…”
Section: Anti-staphylococcal Activity Of Svpla 2 Smentioning
confidence: 59%
“…Examples include crotamine, a myotoxin from venom of the South American rattlesnake, which is structurally related to beta-defensins. The later are antimicrobial peptides found in vertebrate animals [13] , peptides from NajA naja venom [48] , and a venom protein from the inland taipan which all exhibit antimicrobial activity. Previous studies have shown that the naturally occurring proteins display antimicrobial activity [12] .…”
Section: Discussionmentioning
confidence: 99%