Parametric values of Androctonus crassicauda (Oliver, 1807) (scorpiones: buthidae) from Turkey

Özkan, Özcan; Adiguzel, S.; Kar, Sırrı

doi:10.1590/s1678-91992006000400003

Cited by 12 publications

(8 citation statements)

References 4 publications

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“…Also, such venom variability must be taken into consideration in the development of an antivenom product, which must neutralize the toxic effects of venom samples from all scorpions within a species (30). Venom toxicity varies among species or among members of one species that are from different regions (8,13,21). Ismail (11) reported that LD 50 of Leiurus quinquestriatus venom varies from 0.23 mg/kg to 6.5 mg/kg.…”

Section: Sds-page and Western Blottingmentioning

confidence: 99%

Comparison of proteins, lethality and immunogenic compounds of Androctonus crassicauda (Olivier, 1807) (Scorpiones: Buthidae) venom obtained by different methods

Özkan¹,

Kar

Güven

et al. 2007

J. Venom. Anim. Toxins incl. Trop. Dis

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Scorpions are venomous arthropods of the class Arachnida and are considered relatives of spiders, ticks and mites. There are approximately 1,500 species of scorpions worldwide, which are characterized by an elongated body and a segmented tail that ends in a venomous stinger. No specific treatment is available for scorpion envenomation, except for the use of antivenom. The current study aimed at comparing protein content and lethality of Androctonus crassicauda venom extracted by two different methods (electric stimulation and maceration of telsons). The LD50 calculated by probit analysis was 1.1mg/kg for venom obtained by electric stimulation and 39.19mg/kg for venom obtained by maceration of telsons. In the electrophoretic analysis, protein bands of the venom sample obtained by electric stimulation were between 12 and 53kDa (total: five bands), and those of venom extracted by maceration appeared as multiple protein bands, relative to the other venom sample. Low-molecular-weight proteins, revealed by western blotting, played an important immunogenic role in the production of antivenom. Lethality and protein levels varied according to the extraction method; venom obtained by the maceration technique showed lower toxicity than that obtained by electric stimulation

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Section: Sds-page and Western Blottingmentioning

confidence: 99%

Comparison of proteins, lethality and immunogenic compounds of Androctonus crassicauda (Olivier, 1807) (Scorpiones: Buthidae) venom obtained by different methods

Özkan¹,

Kar

Güven

et al. 2007

J. Venom. Anim. Toxins incl. Trop. Dis

Self Cite

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“…Androctonus crassicauda is the most significant scorpion species in Turkey due to scorpionism and antivenom production (8,9). This species can be found in Azerbaijan, Iran, Iraq, Syria, Jordan, Saudi Arabia and Yemen, besides Turkey (5,10,11).…”

Section: Introductionmentioning

confidence: 99%

A study on the genetic diversity of Androctonus crassicauda (Olivier, 1807; Scorpiones: Buthidae) from Turkey

Özkan

Ahmet²,

Zafer

2010

J. Venom. Anim. Toxins incl. Trop. Dis

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Mitochondrial DNA (mtDNA) has been widely employed in phylogeographic and phylogenetic studies. In the present study, the genetic identification of the scorpion Androctonus crassicauda (Olivier, 1807) was carried out by using the 16S mitochondrial gene, since this scorpion represents the most important species in Turkey regarding scorpionism and antivenom production. Two genetic groups were found according to the sequence analysis results, while five different loci at the nucleotide level presented genetic variation in the 16S region when compared to a known A. crassicauda sequence data (GenBank, AJ277598). Nucleotide variations found in the current work constitute the first descriptive report for A. crassicauda. Moreover, future studies may enlighten the genetic and venom composition variations for this scorpion species.

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“…The species is mainly found in Egypt and the Middle East region including the Arabian Peninsula, Iran, Iraq, Israel, and Turkey. 16 Leiurus quinquestriatus is known as the Palestine yellow scorpion. This particular species are found throughout the Middle East, Turkey, Iran, Oman, and Yemen.…”

mentioning

confidence: 99%

Scorpion Venom Causes Apoptosis by Increasing Reactive Oxygen Species and Cell Cycle Arrest in MDA-MB-231 and HCT-8 Cancer Cell Lines

Alasmari

Riyasdeen

Islam

2018

J Evid Based Complementary Altern Med

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Scorpion venom induces apoptosis in breast and colorectal cell lines as reflected by the changes in the cell morphology and cell cycle studies. Furthermore, a high percentage of total reactive oxygen species as well as apoptotic cells also contribute to cell death as observed after venom treatments. To the best of authors' knowledge, this is the first scientific evidence demonstrating the induction of apoptosis and cell cycle arrest by these species of scorpion venoms.

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Parametric values of Androctonus crassicauda (Oliver, 1807) (scorpiones: buthidae) from Turkey

Cited by 12 publications

References 4 publications

Comparison of proteins, lethality and immunogenic compounds of Androctonus crassicauda (Olivier, 1807) (Scorpiones: Buthidae) venom obtained by different methods

Comparison of proteins, lethality and immunogenic compounds of Androctonus crassicauda (Olivier, 1807) (Scorpiones: Buthidae) venom obtained by different methods

A study on the genetic diversity of Androctonus crassicauda (Olivier, 1807; Scorpiones: Buthidae) from Turkey

Scorpion Venom Causes Apoptosis by Increasing Reactive Oxygen Species and Cell Cycle Arrest in MDA-MB-231 and HCT-8 Cancer Cell Lines

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