2006
DOI: 10.1590/s1678-91992006000100004
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Abstract: ABSTRACT:A comparative study on the sensitivity of erythrocytes from different vertebrate species (avian, mammalian and reptilian) to the hemolytic action caused by cardiotoxin isolated from Naja naja atra venom was carried out. Cardiotoxin was able to induce direct hemolysis in washed erythrocytes from several animals, except for llama. The EC50 values from hemolysis of the most sensitive (cat) and the most resistant (snake) animal varied approximately tenfold. According to the cell behavior, it was possible … Show more

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Cited by 5 publications
(2 citation statements)
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“…Cytotoxins are the principal toxic components that cause hemolytic damage, membrane disruption, and circulatory failure [ 29 ]. Cardiotoxin isolated from N. atra venom induces direct hemolysis in washed erythrocytes from several animals [ 30 ]. Although we were unable to identify a single specific component of venom for inducing hemolysis, we did find that N. atra venom induce direct hemolysis in rabbit erythrocytes in the present study, unlike other cobra venoms [ 31 ].…”
Section: Discussionmentioning
confidence: 99%
“…Cytotoxins are the principal toxic components that cause hemolytic damage, membrane disruption, and circulatory failure [ 29 ]. Cardiotoxin isolated from N. atra venom induces direct hemolysis in washed erythrocytes from several animals [ 30 ]. Although we were unable to identify a single specific component of venom for inducing hemolysis, we did find that N. atra venom induce direct hemolysis in rabbit erythrocytes in the present study, unlike other cobra venoms [ 31 ].…”
Section: Discussionmentioning
confidence: 99%
“…Histopathological tissue sections of gastrocnemius muscle, heart, kidney, liver, and lungs of mice injected with venom from all five regions manifested severe pathological anomalies including tissue necrosis associated with haemorrhage and congestion, while control mice group resulted in their normal tissue structures. Several studies with similar histopathology in mice tissues suggest that the potent toxic effect of nonenzymatic fraction of cytotoxins and phospholipase A 2 (PLA 2 ) enzyme leads to these extensive necrotic observations in venom affected tissues by the formation of pores and disturbing the phospholipid structure of lipid bilayer [ 12 , 16 , 54 , 55 ]. Other research reports state similar haemorrhages and congestion in several tissue types as haemostatic disturbances produced by N. naja venom components of metalloproteinases and PLA 2 [ 13 , 35 , 56 ].…”
Section: Discussionmentioning
confidence: 99%