2005
DOI: 10.1590/s1678-91992005000400007
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Abstract: Numerous plants are used as snakebite antidotes in Brazilian folk medicine, including Casearia sylvestris Swartz, popularly known as guaçatonga. In this study, we examined the action of a hydroalcoholic extract from C. sylvestris on the neuromuscular blockade caused by bothropstoxin-I (BthTX-I), a myotoxin from Bothrops jararacussu venom, in mouse isolated phrenic nerve-diaphragm (PND) preparations. Aqueous (8 and 12 mg/ml, n=4 and 5, respectively) and hydroalcoholic (12 mg/ml, n=12) extracts of the leaves of … Show more

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Cited by 23 publications
(19 citation statements)
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References 13 publications
(19 reference statements)
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“…The inhibition of neurotoxic and myotoxic activities of snake venoms in similar experimental models was also previously observed for crude extracts of Tabernaemontana catharinensis, Casearia sylvestris, Pentaclethra macroloba, Baccharis trimera and Mandevilla velutina (27,39,(43)(44)(45)(46)(47).…”
Section: Resultssupporting
confidence: 82%
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“…The inhibition of neurotoxic and myotoxic activities of snake venoms in similar experimental models was also previously observed for crude extracts of Tabernaemontana catharinensis, Casearia sylvestris, Pentaclethra macroloba, Baccharis trimera and Mandevilla velutina (27,39,(43)(44)(45)(46)(47).…”
Section: Resultssupporting
confidence: 82%
“…This result could indicate that 1 mg/mL Cg extract could prevent the venom activity propagation. Since only higher Cg concentrations showed pharmacological effect, the bioactive compounds could be concentrated in the extract, which is interesting for a future C. gossypiosperma bio-prospection.The inhibition of neurotoxic and myotoxic activities of snake venoms in similar experimental models was also previously observed for crude extracts of Tabernaemontana catharinensis, Casearia sylvestris, Pentaclethra macroloba, Baccharis trimera and Mandevilla velutina (27,39,(43)(44)(45)(46)(47).Our experience with C. sylvestris (27, 39) using the same experimental model and all attempts to identify the bioactive compounds (mainly rutin) showed that this plant protected the muscle against the toxic effects of Bjssu venom due to phytocomplex formation. Different molecules in the plant constitution inhibit Bjssu venom activity in different ways, for example, coumarin from Mikania laevigata and tannin from Plathymenia reticulata.…”
supporting
confidence: 79%
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“…Nevertheless, in many regions numerous plants have been successfully used as snake venom antidotes (6,7). A preliminary study screened 17 plants for anti-snake venom activity and showed that only Mimosa pudica can significantly neutralize the lethal effects of five common species of venomous snakes (8).…”
Section: Introductionmentioning
confidence: 99%
“…The most studied antiophidian plants at the neuromuscular junction exhibits an in vitro ability in counteracting the neuromuscular blockade-induced by venoms, such as: Casearia sylvestris Sw. [14,15], Plathymenia reticulata Benth. [16], Mikania laevigata Sch.…”
Section: Resultsmentioning
confidence: 99%