“…), but was only significant difference at 80 day in infected and treated groups. Generally, , it was noticed an increased concentration Azotemia (high serum values of urea and creatinine) of infected mice, this result agrees with several authors ( Ferrer, et al, 1992;Kontos & Koutinas, 1993;Denerolle, 1996 ;Ciaramella, et al, 1997;Slappendel & Ferrer, 1998;Solano-Gallega, et al, 2001;Langoni, et al, 2005 andJoshi, et al, 2006). However, some studies disagree with our data on the serum urea and creatinine levels that are usually normal (Pagliano, et al, 2005;Bhattacharya, et al, 2006 andLópez-Peña, et al,2009(. In the present study, in kidneys of infected mice with VL was observed hemorrhages, destruction in some renal tubules, lymphocyte infiltrations glomerular inflammation, glomerular tuft was increased, intravascular accumulations of neutrophils and monocytes, destructions of Bowman's capsule, diffuse chronic interstitial inflammation.…”