Role of cytokines, NO, and H2O2 on the immunopathology of Leptospirosis in genetically selected mice

Marinho, Márcia; Langoni, Hélio; Oliveira, S. L.; Lima, Verônica Castro; Peiró, Juliana Regina; Perri, S. H. V.; Carreira, Rodrigo da Costa

doi:10.1590/s1678-91992005000200009

Cited by 8 publications

(5 citation statements)

References 9 publications

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“…Marinho et al (5) observed similar results in the production of cytokines using Leptospira interrogans Icterohaemorrhagiae. We suggest that factors related to inflammatory response are associated with the immunopathogenesis of the disease.…”

Section: Discussionmentioning

confidence: 54%

Cytokine and antibody production during murine leptospirosis

Marinho¹,

Silva²,

Lima³

et al. 2006

J. Venom. Anim. Toxins incl. Trop. Dis

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The aim of the present study was to investigate the kinetics of humoral and cellular responses during leptospirosis. We observed that the presence of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) was associated with antibody production and bacterial recovery, and the compromising of both TNF-alpha and IL-6 in the immunopathogenesis of leptospirosis during an experimental infection of BALB/c mice inoculated with Leptospira interrogans serovar Canicola was verified. Results showed higher levels of TNF-alpha and IL-6 in the initial phase of infection, in which the greatest bacterial clearance was observed. However, when the bacterial recovery was compared with the kinetics of the production of antibodies, the results revealed a kinetics proportionally inverted to antibody production. This fact may be related to some inhibitory factor which could be responsible for the selective suppression of the cellular immune response. We concluded that during leptospirosis there was a greater mobilization of the cellular immune response activity, mainly in the initial phase of the infectious process, for posterior involvement of the humoral response, and that both TNF-alpha and IL-6 could be associated with the immunopathogenesis of the disease

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Section: Discussionmentioning

confidence: 54%

Cytokine and antibody production during murine leptospirosis

Marinho¹,

Silva²,

Lima³

et al. 2006

J. Venom. Anim. Toxins incl. Trop. Dis

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“…In the case of leptospirosis, it might be more useful to focus on cytokines with serum levels that have been repeatedly associated with leptospiral infections, studying all of their genetic polymorphisms and suspected impact on promoter activity or protein funtion. This could be the case of IL-4 [35,37], IL-6 [37,38], IL-12 [37,39], TNF-␣ [37][38][39][40][41], IFN-␥ [37,39], and IL-10 [35,42]. Genetic polymorphisms have been providing important clues into the host's ability to successfully deal with infection.…”

Section: Discussionmentioning

confidence: 99%

Role of human leukocyte antigen, killer-cell immunoglobulin-like receptors, and cytokine gene polymorphisms in leptospirosis

et al. 2009

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“…4,5 The presence of inflammatory cytokines has also been confirmed in sera of patients with leptospirosis. 6 Marinho and others 7,8 showed that high levels of tumor necrosis factor (TNF)-a and interleukin (IL)-6 in the supernatant of peritoneal macrophage cellular culture of genetically selected mice inoculated with a sample of Leptospira interrogans serovars Canicola was determined by immunoenzymatic assays. The lungs are an important target organ in leptospirosis presenting hemorrhagic pneumonitis with varying degrees of severity.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Disease in Hamsters Infected with Leptospira interrogans: Histopathologic Findings and Cytokine mRNA Expressions

Marinho

Oliveira-Júnior²,

Monteiro³

et al. 2009

The American Journal of Tropical Medicine and Hygiene

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Abstract. Our aim was to evaluate the pulmonary changes induced by Leptospira interrogans infection in hamsters, and the gene expression of endogenous mediators in lung fragments during 28 days of observation. The animals were euthanized on days 4, 7, 14, 21, and 28 post-inoculation. Histopathologic lung analysis showed hemorrhage, pneumonia, alveolar congestion, and infiltrated cellular areas, with increasing severity until day 21 post-inoculation. Tumor necrosis factor (TNF)-a mRNA expression enhanced in first days with peak on day 4 and slightly decreased in the final phase. The interleukin (IL)-10 remained relatively constant throughout the period, with the exceptions of days 4 and 14. The endothelial nitric-oxide synthesis (eNOS) showed an increased expression on day 4, followed by an augment on days 7 and 14, and remaining constant up to day 28 post-infection. Our results demonstrate that inoculation of L. interrogans sorovar Icterohaemorrhagiae induced pulmonary lesions, including pulmonary hemorrhage, supporting that the lung is a target organ.

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Role of cytokines, NO, and H2O2 on the immunopathology of Leptospirosis in genetically selected mice

Cited by 8 publications

References 9 publications

Cytokine and antibody production during murine leptospirosis

Cytokine and antibody production during murine leptospirosis

Role of human leukocyte antigen, killer-cell immunoglobulin-like receptors, and cytokine gene polymorphisms in leptospirosis

Pulmonary Disease in Hamsters Infected with Leptospira interrogans: Histopathologic Findings and Cytokine mRNA Expressions

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