Guest editorial: the etiology and pathogenesis of periodontitis revisited

Dyke, Thomas E. Van

doi:10.1590/s1678-77572009000100001

Cited by 35 publications

(34 citation statements)

References 3 publications

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“…It is generally accepted that the build-up of plaque bacteria on the tooth surface causes periodontal disease, however the specific organisms involved in the initiation of disease and subsequent events are not yet known (Van Dyke, 2009). It has been postulated that specific antigens or enzymes produced by bacteria in the plaque biofilm activate the host inflammatory response, which causes the ligaments and bones that support the tooth to become inflamed and progressively destroyed (Williams, 1990).…”

Section: Introductionmentioning

confidence: 99%

A longitudinal assessment of changes in bacterial community composition associated with the development of periodontal disease in dogs

Wallis¹,

Marshall²,

Colyer³

et al. 2015

Veterinary Microbiology

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Periodontal disease is the most widespread oral disease in dogs. Whilst the involvement of bacteria in the aetiology of periodontitis is well established the role of individual species and their complex interactions with the host is not well understood. The objective of this research was therefore to perform a longitudinal study in dogs to identify the changes that occur in subgingival bacterial communities during the transition from mild gingivitis to the early stages of periodontitis (<25% attachment loss). Subgingival plaque samples were collected from individual teeth of 52 miniature schnauzer dogs every six weeks for up to 60 weeks. The microbial composition of plaque samples was determined using 454-pyrosequencing of the 16S rDNA. A group of aerobic Gram negative species, including Bergeyella zoohelcum COT-186, Moraxella sp. COT-017, Pasteurellaceae sp. COT-080, and Neisseria shayeganii COT-090 decreased in proportion as teeth progressed to mild periodontitis. In contrast, there was less evidence that increases in the proportion of individual species were associated with the onset of periodontitis, although a number of species (particularly members of the Firmicutes) became more abundant as gingivitis severity increased. There were small increases in Shannon diversity, suggesting that plaque community membership remains relatively stable but that bacterial proportions change during progression into periodontitis. This is the first study to demonstrate the temporal dynamics of the canine oral microbiota; it showed that periodontitis results from a microbial succession predominantly characterised by a reduction of previously abundant, health associated taxa.

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Section: Introductionmentioning

confidence: 99%

A longitudinal assessment of changes in bacterial community composition associated with the development of periodontal disease in dogs

Wallis¹,

Marshall²,

Colyer³

et al. 2015

Veterinary Microbiology

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“…These microorganisms release substances that strictly injury periodontal tissues, in addition to inducing tissue destruction by inflammatory and immunologic responses of the host 31 .…”

Section: Introductionmentioning

confidence: 99%

Experimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in rats

et al. 2010

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ObjectiveThe aim of this study was to compare subgingival irrigation with tetracycline hydrochloride (TTC-HCL) as adjunctive treatment to scaling and root planning (SRP) on induced periodontitis in rats. Material and methodsIn 60 rats, periodontal disease was ligature-induced at the mandibular left first molar. After 7 days, the ligature was removed and all animals were submitted to SRP, and divided into 2 groups according to the following treatment: C (n=30) - subgingival irrigation with 1 mL of saline; T (n=30) - subgingival irrigation with 1 mL of TTC-HCL (50 mg/mL). Ten animals in each group were euthanized at 7, 15 and 30 days posttreatment. The histometric values were statistically analyzed (p<0.05). ResultsIn the histometric analysis, at 7, 15 and 30 days, Group T (0.72±0.05 mm2, 0.57±0.14 mm2, 0.62±0.07 mm2), showed less bone loss (p<0.05) than Group C (1.35±0.25 mm2; 1.40±0.31 mm2; 1.29±0.27 mm2), respectively. ConclusionsSubgingival irrigation with TTC-HCL was an effective adjunctive treatment for periodontal disease induced in rats.

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“…The chronic inflammation is the main mechanism that promotes the destruction and dental fragility, facilitating the occurrence of bacteremia. In addition to continuing production of interleukins and cytokines induce exacerbation of thromboembolic phenomena and atherosclerotic 3,4,19 .…”

Section: Resultsmentioning

confidence: 99%

“…This parameter is the primary evaluator of recovery and healing of periodontal disease 2,3 . The recovery of this barrier has a fundamental importance to avoid bacteremia during feeding or dental procedures.…”

Section: Resultsmentioning

confidence: 99%

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Effect of andiroba oil on periodontitis in Wistar rats

Carmona¹,

Teixeira

Brito

et al. 2013

Acta Cir. Bras.

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PURPOSE:To evaluate the effects of andiroba oil on the periodontitis in rats. METHODS:The periodontitis was induced by the placement of cotton ligatures around the cervix of the second upper molars on fifteen rats, and waiting fifty days. The animals were randomly distributed into three groups: saline group, andiroba oil group and meloxican group, differentiated by substance used in the treatment of periodontitis. The groups received the respective substance by gavage for seven days, after the periodontitis induced. It was analyzed the score of inflammatory cells and the measurement from the cementoenamel junction to the bone crest. RESULTS:The andiroba oil group (p=0.008) and meloxican group (p=0.0347) show a less score of inflammatory cells than saline group, however there weren't difference between them (p=0.2754). Regarding the analysis of measurement from the cemento-enamel junction to the bone crest, there was no difference between groups studied (p=0.3451). CONCLUSION:Andiroba oil decreased the quantity of inflammatory cells, however, it didn't have an effect on the measurement of alveolar bone loss, like the treatment with Meloxican ® .

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Guest editorial: the etiology and pathogenesis of periodontitis revisited

Cited by 35 publications

References 3 publications

A longitudinal assessment of changes in bacterial community composition associated with the development of periodontal disease in dogs

A longitudinal assessment of changes in bacterial community composition associated with the development of periodontal disease in dogs

Experimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in rats

Effect of andiroba oil on periodontitis in Wistar rats

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