2008
DOI: 10.1590/s1678-77572008000400012
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Abstract: The effect of Aloe vera on the reduction of plaque and gingivitis was evaluated in a randomized, parallel and double-blind clinical trial. Subjects were randomly allocated to the test group (n=15) – dentifrice containing Aloe vera - or the control group (n=15) – fluoridated dentifrice. Plaque index (PI) and gingival bleeding index (GBI) were assessed at days 0 and 30. Subjects were asked to brush their teeth with the control or test dentifrice, three times a day, during a 30-day period. There was a significant… Show more

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Cited by 75 publications
(96 citation statements)
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“…After 100,000 cycles of brushing, both dentifriceAloe vera and Colgate Total 12 -exhibited microhardness values as same as the baseline time, which showed the effectiveness of the both dentifrice in treatment of white spot lesion. In a previous clinical trials, Aloe vera toothpaste did not show any significant differences from fluoridated dentifrices for the control and reduction of dental plaque and gingivitis 11 . It is highlighted that fluoride and Aloe vera are incompatible because the therapeutic potential of Aloe vera is lost together with fluoride.…”
Section: Discussionmentioning
confidence: 68%
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“…After 100,000 cycles of brushing, both dentifriceAloe vera and Colgate Total 12 -exhibited microhardness values as same as the baseline time, which showed the effectiveness of the both dentifrice in treatment of white spot lesion. In a previous clinical trials, Aloe vera toothpaste did not show any significant differences from fluoridated dentifrices for the control and reduction of dental plaque and gingivitis 11 . It is highlighted that fluoride and Aloe vera are incompatible because the therapeutic potential of Aloe vera is lost together with fluoride.…”
Section: Discussionmentioning
confidence: 68%
“…In vitro studies have demonstrated the antimicrobial effect of an Aloe vera based dentifrice, which promoted the growth inhibition of several oral microorganisms, such as S. mutans, S. sanguis, A. viscosus and C. albicans [16][17] . In another clinical study, the Aloe vera based dentifrice did not show any additional effect neither on plaque nor gingivitis compared with the fluoride dentifrice 11 . Although different studies discussed about the benefits of Aloe vera tooth gel in oral conditions, the effects of toothbrushing using Aloe vera based dentifrice on the initial caries lesions must be reported.…”
Section: Effects Of Fluoride and Aloe Vera Tooh Gel In Artificial Whimentioning
confidence: 87%
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“…[14] Unlike previous plaque associated studies on ALV, present study is the first one to follow a crossover design instead of parallel as it is more standardized and recommended method for a four day plaque re-growth study. [17][18][19][20][21][22] A particular advantage of a crossover design is that each subject serves his or her own control so it reduces the influence of confounding that arises because of individual variables that effect plaque formation like the salivary flow and composition, existing plaque retention sites, pre-existing gingivitis, dietary habits, and the composition of pellicle. [23,24] Also optimal crossover designs are statistically significant so require fewer subjects than non crossover design.…”
Section: Discussionmentioning
confidence: 99%