“…In vitro studies have demonstrated the antimicrobial effect of an Aloe vera based dentifrice, which promoted the growth inhibition of several oral microorganisms, such as S. mutans, S. sanguis, A. viscosus and C. albicans [16][17] . In another clinical study, the Aloe vera based dentifrice did not show any additional effect neither on plaque nor gingivitis compared with the fluoride dentifrice 11 . Although different studies discussed about the benefits of Aloe vera tooth gel in oral conditions, the effects of toothbrushing using Aloe vera based dentifrice on the initial caries lesions must be reported.…”