Cytoprotective role of the aqueous extract of Terminalia chebula on renal epithelial cells

Tayal, Shivam; Duggal, Sanjeev; Bandyopadhyay, Probir K.; Aggarwal, Archana; Tandon, S. K.; Tandon, Chanderdeep

doi:10.1590/s1677-55382012000200008

Cited by 15 publications

(13 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The minimal cytotoxicity observed in the extracts investigated may be due to the presence of cytoprotective components. This cytoprotective role of plants have been reported in other studies on plant extracts [41]. In our study, this is an indication that these extracts might serve as potential candidates for the development of safe and less toxic drugs.…”

Section: Discussionsupporting

confidence: 87%

Identification of Traditional Medicinal Plant Extracts with Novel Anti-Influenza Activity

et al. 2013

View full text Add to dashboard Cite

The emergence of drug resistant variants of the influenza virus has led to a need to identify novel and effective antiviral agents. As an alternative to synthetic drugs, the consolidation of empirical knowledge with ethnopharmacological evidence of medicinal plants offers a novel platform for the development of antiviral drugs. The aim of this study was to identify plant extracts with proven activity against the influenza virus. Extracts of fifty medicinal plants, originating from the tropical rainforests of Borneo used as herbal medicines by traditional healers to treat flu-like symptoms, were tested against the H1N1 and H3N1 subtypes of the virus. In the initial phase, in vitro micro-inhibition assays along with cytotoxicity screening were performed on MDCK cells. Most plant extracts were found to be minimally cytotoxic, indicating that the compounds linked to an ethnomedical framework were relatively innocuous, and eleven crude extracts exhibited viral inhibition against both the strains. All extracts inhibited the enzymatic activity of viral neuraminidase and four extracts were also shown to act through the hemagglutination inhibition (HI) pathway. Moreover, the samples that acted through both HI and neuraminidase inhibition (NI) evidenced more than 90% reduction in virus adsorption and penetration, thereby indicating potent action in the early stages of viral replication. Concurrent studies involving Receptor Destroying Enzyme treatments of HI extracts indicated the presence of sialic acid-like component(s) that could be responsible for hemagglutination inhibition. The manifestation of both modes of viral inhibition in a single extract suggests that there may be a synergistic effect implicating more than one active component. Overall, our results provide substantive support for the use of Borneo traditional plants as promising sources of novel anti-influenza drug candidates. Furthermore, the pathways involving inhibition of hemagglutination could be a solution to the global occurrence of viral strains resistant to neuraminidase drugs.

show abstract

Section: Discussionsupporting

confidence: 87%

Identification of Traditional Medicinal Plant Extracts with Novel Anti-Influenza Activity

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Similarly, other groups have reported that oxalate decreases cell viability as determined by LDH release and trypan blue exclusion in LLC-PK1 and MDCK cells [8,38]. Tayal et al [39] used MDCK cell lines to study the effect of Terminalia chebula extract on oxalate induced renal injury and found that the cell injury (LDH release) was significantly reduced in cells treated with the extract. The inhibitory role of various plant species from Algeria in calcium oxalate growth was investigated in vitro by Beghalia et al [40].…”

Section: Discussionmentioning

confidence: 86%

Isolation and prevention of calcium oxalate-induced apoptotic death and oxidative stress in MDCK cells by diosgenin

Saha

Goswami

Anupama

2014

Chemico-Biological Interactions

View full text Add to dashboard Cite

“…The vegetable extracts such as Holarrhena antidysenterica, Origanum vulgare and Terminalia chebula can inhibit cell damage, preferably by inhibiting free radicals. [28][29][30][31] Protective action of Paronychia argentea, B. ligulata, Quercus salieina, Achyranthus Aspera and Ammi visnaga also occurs due to stimulation of antioxidant activity. [23,31,32] The effects of the main plant extracts are given in Table 1.…”

Section: In Vitro Studiesmentioning

confidence: 99%

Plant Extracts in Hyperoxaluria Treatment: A Review of Experimental and Clinical Research

Stepanova

2019

EJMO

View full text Add to dashboard Cite

This article is a review of the scientific literature. The purpose of this research was the systematization of the updated information on potential herbal medicine in hyperoxaluria treatment. We analysed the English language scientific literature Medline published from January 2008 to December 2018. Data in vitro, experimental and clinical studies demonstrated antiurolithiatic properties of many plant extracts. Reducing hyperoxaluria is mainly caused by the ability of plants to inhibit nucleation and agglomeration of crystals by changing the ionic composition of urine and due to diuretic, nephroprotective, antioxidant and antibacterial effects.

show abstract

Cytoprotective role of the aqueous extract of Terminalia chebula on renal epithelial cells

Abstract: ARTICLE INFO ___________________________________________ _

Cited by 15 publications

References 25 publications

Identification of Traditional Medicinal Plant Extracts with Novel Anti-Influenza Activity

Identification of Traditional Medicinal Plant Extracts with Novel Anti-Influenza Activity

Isolation and prevention of calcium oxalate-induced apoptotic death and oxidative stress in MDCK cells by diosgenin

Plant Extracts in Hyperoxaluria Treatment: A Review of Experimental and Clinical Research

Contact Info

Product

Resources

About

Cytoprotective role of the aqueous extract of Terminalia chebula on renal epithelial cells

Abstract: ARTICLE INFO _______________________________________________________________ _____________________

Cited by 15 publications

References 25 publications

Identification of Traditional Medicinal Plant Extracts with Novel Anti-Influenza Activity

Identification of Traditional Medicinal Plant Extracts with Novel Anti-Influenza Activity

Isolation and prevention of calcium oxalate-induced apoptotic death and oxidative stress in MDCK cells by diosgenin

Plant Extracts in Hyperoxaluria Treatment: A Review of Experimental and Clinical Research

Contact Info

Product

Resources

About

Abstract: ARTICLE INFO ___________________________________________ _