Human papillomavirus and penile cancers in Rio de Janeiro, Brazil: HPV typing and clinical features

Scheiner, Marcos Antônio Maurício; Campos, Maria Martha; Ornellas, Antônio Augusto; Chin, Eduardo Wei Kin; Ornellas, Maria Helena; Andrada-Serpa, Maria José

doi:10.1590/s1677-55382008000400009

Cited by 42 publications

(42 citation statements)

References 32 publications

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“…HPV positive tumors show a variable prognostic outcome. In a previous article we reported the analysis of 80 consecutive cases of patients with penile cancers and HPV status was not signifi cantly associated with the presence of re- gional metastases (21). Up to now, P53 status may correlate with survival in T1 disease but further studies are required to establish the link to lymph node spread (22) Therefore, it is still necessary to fi nd biomarkers for early detection of metastases, prognosis and follow-up of this disease (22).…”

Section: Discussionmentioning

confidence: 97%

Downregulation of C3 and C4A/B complement factor fragments in plasma from patients with squamous cell carcinoma of the penis

Ornellas¹,

Ornellas²,

Chinello³

et al. 2012

Int. braz j urol.

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Purpose: To investigate the use of ClinProt technique to identify cancer markers in plasma of patients suffering from squamous cell carcinoma of the penis (SCCP). Materials and Methods: Plasma of 36 healthy subjects and 25 patients with penile carcinoma who underwent surgical treatment between June 2010 and June 2011 was collected and analyzed by the ClinProt/MALDI/ToF technique. Then the peptides were identifi ed from the C8 MB eluted fraction of patients' and control subjects' plasma by LIFT MS/MS. Results: A cluster of 2 peptides (A=m/z 1897.22 ± 9 Da and B=m/z 2021.99 ± 9 Da) was able to discriminate patients from control subjects. Cross validation analysis using the whole casuistic showed 62.5% and 86.76% sensitivity and specifi city, respectively. The cluster also showed very high sensitivity (100%) and specifi city (97%) for SCCP patients that died due to the disease. Furthermore, patients with lymph node involvement presented sensitivity and specifi city of 80% and 97%, respectively. These two peptides were identifi ed by the proteomic approach based on a MALDI-TOF/TOF as fragments of C3 (m/z 1896.17) and C4a/b (m/z 2021.26) complement proteins. Conclusions:The results showed that as the disease progresses, the fragments C3 and C4 A/B are less expressed in comparison with healthy subjects. These results may be useful as prognostic tools.

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Section: Discussionmentioning

confidence: 97%

Downregulation of C3 and C4A/B complement factor fragments in plasma from patients with squamous cell carcinoma of the penis

Ornellas¹,

Ornellas²,

Chinello³

et al. 2012

Int. braz j urol.

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“…Only 30% to 60% of patients with HPV infection are correctly identified by these methods (17,21,22). In another study conducted by our group, it was possible using a more sophisticated method to detect HPV DNA in 75% of patients with invasive carcinomas (23).…”

Section: Commentsmentioning

confidence: 99%

Epidemiological aspects of penile cancer in Rio de Janeiro: evaluation of 230 cases

Koifman

Vides²,

Koifman

et al. 2011

Int. braz j urol.

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Purpose: To determine epidemiological characteristics of penile cancer in Rio de Janeiro, its associated risk factors and clinical manifestations. Patients and Methods: Between 2002 and 2008 we evaluated 230 patients at three public institutions, considering age, ethnicity, birthplace, marital status, educational level, religion, tobacco smoking, presence of phimosis and practice of circumcision. Results: The ages ranged from 25 to 98 years, with an average of 58.35 years. Of the 230 patients, 167 (72.7%) were from the southeast region of Brazil (which includes Rio de Janeiro) and 45 (19.5%) were from the northeast of the country. Most patients were white (67.3%), married (58.6%), smokers (56.5%) and had not completed primary school (71.3%). The predominant religion was Catholic (74.8%). Of the 46 (20%) circumcised patients, only 1 (2.2%) had undergone neonatal circumcision. Grade I tumors were present in 87 (37.8%) of the patients, grade II in 131 (56.9%) and grade III in 12 (5.3%). Lymphovascular embolization was observed in 63 (27.3%) and koilocytosis in 124 (53.9%) patients. Of the total, 41.3% had corpora cavernosa or corpus spongiosum infiltration, and 40 (17.4%) had urethral invasion. Prophylactic lymphadenectomy was performed on 56 (36.1%), therapeutic lymphadenectomy on 84 (54.2%) and hygienic lymphadenectomy for advanced disease on 15 (9.7%) patients. The median time between the lesion onset and clinical diagnosis was 13.2 months. The mean follow up was 28.8 months. Conclusion: Most of our patients were born in this state and had low socioeconomic status. Most of them were white men, married, smokers, uncircumcised, of the Catholic faith and in their sixties or older. Their disease was in most cases diagnosed only in the advanced stages.

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“…These factors are coincident with our results: most patients had an informal job (67%), with income lower than two minimum wages and many were illiterates (50%). Most studied patients had a bad cultural status, with compromised personal hygiene, with high risk sexual behavior (unprotected sexual relations, promiscuity) and exposition to sexually transmitted diseases (HPV) that could be related to PC (13). It is also important to stress the habitus of zoophilia, common in interior regions of the country, increasing the chance of PC occurrence, as related by Zequi et al (14).…”

Section: Discussionmentioning

confidence: 95%

Epidemiological study of penile cancer in Pernambuco: experience of two reference centers

et al. 2014

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ARTICLE INFO ______________________________________________________________ ______________________Objectives: To investigate and analyze the epidemiological profile of penile cancer in the state of Pernambuco and compare this information with other studies related to the issue. Material and Methods:We conducted a retrospective, observational and descriptive study of all patients with penile cancer in two reference centers in Pernambuco -Brazil, from 2007 to 2012. The variables studied were: age, region from the state, socio--economic situation, previous postectomy, smoking, time from the beginning of injury to diagnosis, staging of the primary lesion, tumor differentiation, treatment performed and death due to cancer. Results:The total number of patients was 88. The highest prevalence was seen in those aged between 66 and 75 years. About the socio-economic situation, 67% worked informally and 64.8% received up to two minimum wages. Of all patients, 57% were married and 50% illiterate. The Metropolitan Region of Recife was the one with the highest number of cases, 41%. Tobacco smoking was reported in 48.9% of cases and prior postectomy in 3.4%. Most often it was observed an average period of six months from the onset of symptoms to diagnosis. And when the lesion was diagnosed, it usually had 2 to 5 cm (64.7%), stage T2 in 50% and well differentiated in 79.6%. Partial penectomy was performed in 76.1% and total in 17%. Death was observed in 27.3%. Conclusion:The clinical profile and epidemiological characteristics found in this study are similar to other national and international studies related to the issue, i.e., typical of underdeveloped or developing countries.

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Human papillomavirus and penile cancers in Rio de Janeiro, Brazil: HPV typing and clinical features

Cited by 42 publications

References 32 publications

Downregulation of C3 and C4A/B complement factor fragments in plasma from patients with squamous cell carcinoma of the penis

Downregulation of C3 and C4A/B complement factor fragments in plasma from patients with squamous cell carcinoma of the penis

Epidemiological aspects of penile cancer in Rio de Janeiro: evaluation of 230 cases

Epidemiological study of penile cancer in Pernambuco: experience of two reference centers

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