Influence of antisperm antibodies in the semen on intracytoplasmic sperm injection outcome

Abstract

Our data indicate that intracytoplasmic sperm injection (ICSI) outcomes are not influenced by ASA levels on sperm.

Unexplained Male infertility: diagnosis and Management

“…One study showed that couples who had a poor fertilization rate during IVF (6%) showed a dramatic increase in fertilization rate with ICSI treatment (79%) which was comparable to an ASA negative group (68%) (113). In another study, Esteves et al reported that the outcome of ICSI in men with autoimmune infertility was not influenced by the percentage of ASA-bound spermatozoa (114).…”

Roles of Antiphospholipid Antibodies, Antithyroid Antibodies and Antisperm Antibodies in Female Reproductive Health

“…Vujisic et al [65] reported that the presence of ASAs on sperm or in the serum and follicular fluid was not associated with poorer IVF outcomes in couples with good quality semen characteristic. Esteves et al [66] demonstrated that ICSI outcomes are not influenced by ASA levels [66]. …”

Role and Significance of Sperm Function in Men with Unexplained Infertility

“…The findings of sperm agglutination, "shaking motility," or both, during conventional semen analysis are highly suggestive of elevated ASA titers [7]. The term "agglutination" describes spermatozoa that are stuck to each other by antibodies.…”

“…As such, it is important not only to have 50 % or more motile spermatozoa attached to the beads but also an impairment in sperm function caused by these elevated ASA levels, as determined by other sperm function tests such as the sperm-mucus penetration test, zona binding assays, and the AR response to stimulants [12]. ASA alone have a poor correlation with natural, IVF, or ICSI pregnancy rates [7]. Moreover, treatment of immunologic-male infertility with corticosteroids not only controversial but also associated with many side effects.…”