Free serum testosterone level in male rats treated with tribulus alatus extracts

El-Tantawy, Walid Hamdy; Temraz, Abeer; El-Gindi, Omayma D.

doi:10.1590/s1677-55382007000400015

Cited by 45 publications

(25 citation statements)

References 9 publications

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“…Thus, BTB appears to be superior to some potential herbal aphrodisiacs. Since BTB can elevate serum testosterone level a possibility exists that it may facilitate the above-mentioned sexual functions with regular long-term administration (El-Tantawy et al, 2007;Thakur and Dixit, 2007;Yakubu et al, 2007). However, further studies are required to clarify this view.…”

Section: Discussionmentioning

confidence: 99%

Effect of black tea brew of Camellia sinensis on sexual competence of male rats

Ratnasooriya

Fernando

2008

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Effect of black tea brew of Camellia sinensis on sexual competence of male rats

Ratnasooriya

Fernando

2008

Journal of Ethnopharmacology

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“…An alternative method to increase the endocrine secretion of endogenous androgens is to stimulate the endocrine system to release various hormones that in turn mimic, boost or result in the release of higher serum androgen levels. For example, some of the so called androgenic herbs could mimic the endocrine signaling process in the body and increase serum level of androgen hormones, among which, tribulus terrestris L. (TT) is one of the best known endocrine testosterone booster (El-Tantawy et al 2007;Gauthaman et al 2002;Gauthaman and Ganesan 2008;Qureshi et al 2014;Singh et al 2012). TT, a flowering plant native to the warm temperate and tropical regions of Europe, southern Asia, Africa and Australia, has been widely used not only in traditional, ancient medicine in China, India (Ayurvedic medicine) and Greece for the treatment of a variety disorders (Chhatre et al 2014;Qureshi et al 2014), but also in Western countries as a testosterone booster, an enhancer of libido and adaptogenic aid for healthy men and competitive athletes largely due to its claimed effects on the induction of endogenous T secretion as described above.…”

mentioning

confidence: 99%

“…TT extracts (primary saponins) are commonly used by athletes and bodybuilders who are concerned about increasing muscle mass, strength and improving performance, even though this biological pathway is not entirely proven. The main claimed effect of TT is the increase in anabolic and androgenic action through the activation of endogenous testosterone production, thus providing a natural, safe and legal method to increase testosterone levels with no side effects (Brown et al 2001;El-Tantawy et al 2007;Gauthaman et al 2002;Singh et al 2012). However, conflicting results about the effect of TT extracts on serum level of androgens and performance have been reported in different in intact and castrated male rats (Martino-Andrade et al 2010), Rugby athletes (Rogerson et al 2007), resistance training men (Antonio et al 2000;Brown et al 2000) and untrained females (Saudan et al 2008).…”

mentioning

confidence: 99%

Effects of Tribulus terrestris saponins on exercise performance in overtraining rats and the underlying mechanisms

Yin

Wang

et al. 2016

Can. J. Physiol. Pharmacol.

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The objective of this study was to determine the effects of Tribulus terrestris L. (TT) saponins on exercise performance and the underlying mechanisms. A rat overtraining model was established and animals were treated with TT extracts (120 mg/kg body mass) 30 min before each training session. Serum levels of testosterone and corticosterone and levels of androgen receptor (AR) and insulin growth factor-1 receptor (IGF-1R) in the liver, gastrocnemius, and soleus were determined by ELISA and Western blot. Treatment of rats with TT saponins significantly improved the performance of the overtraining rats, reflected by the extension of time to exhaustion, with a concomitant increase in body mass, relative mass, and protein levels of gastrocnemius. Overtraining alone induced a significant decrease in the serum level of testosterone. In contrast, treatment with TT saponins dramatically increased the serum level of testosterone in overtraining rats to about 150% of control and 216% of overtraining groups, respectively. In addition, TT saponins resulted in a further significant increase in AR in gastrocnemius and significantly suppressed the overtraining-induced increase in IGF-1R in the liver. These results indicated that TT saponins increased performance, body mass, and gastrocnemius mass of rats undergoing overtraining, which might be attributed to the changes in androgen-AR axis and IGF-1R signaling.

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“…Additionally, clinical data indicate the stimulatory effects of TT on sperm quantity and quality and improved sexual response in men. Increased androgen levels have also been reported following T terrestris administration in nonhuman primates, rats, and rabbits (Gauthaman & Ganesan;El-Tantawy et al, 2007), but most of these effects were short-lived and showed no clear dose-response relationship. In addition, there is no consensus on the mechanism underlying the effects of TT on sexual performance and spermatogenesis.…”

Section: Cisplatin (Cis-[pt(ii)(nh(3))(2)cl(2)]([ptclmentioning

confidence: 99%

Protective Effect of Tribulus terrestris Hydroalcoholic Extract against Cisplatin-Induced Cytotoxicity on Sperm Parameters in Male Mice

et al. 2014

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SUMMARY:Cisplatin is an anti-cancer drug used in chemotherapy. One of the limiting side effects of cisplatin is decreasing genital gland function, azoospermia and oligospermia. Tribulus terrestris has been used as an aphrodisiac. The present study amid to investigate protective effect of Tribulus terrestris hydroalcoholic extract against cisplatin-induced cytotoxicity on sperm parameters in mice. Male adult mice (n=30) were divided into control and 4 experimental groups (n=6). Control group received saline, first experimental group received cisplatin (5.5 mg/kg) and other three experimental groups received cisplatin (5.5 mg/kg) and different doses of hydroalcoholic extact of Tribulus terrestris (100, 300 and 500 mg/kg/i.p) respectively. On the day after the last injection, blood samples were collected for serum Nitric oxide (NO) assay. Also weights of body and testis, sperm parameters and seminiferous tubules diameter were assessed. Data analysis was performed using one-way ANOVA followed by Tukeys' test. The results showed that cisplatin lead to a reduction in the weight of body and testes, sperm parameters and increased level serum of NO significantly compared to the control group (P<0.05), while in treated groups with Tribulus terrestris, the weights of body and testes, sperm parameters, seminiferous tubules diameter were significantly higher compared with cisplatin group (P<0.05), but serum level of NO did not show significant differences. The study demonstrates that extract of Tribulus terrestris could protective effect against cisplatin-induced cytotoxicity on sperm parameters that may be related to the presence of antioxidant components acting via a multitude of central and peripheral mechanisms.

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Free serum testosterone level in male rats treated with tribulus alatus extracts

Abstract: Tribulus alatus extract appears to possess aphrodisiac activity due to its androgen increasing property.

Cited by 45 publications

References 9 publications

Effect of black tea brew of Camellia sinensis on sexual competence of male rats

Effect of black tea brew of Camellia sinensis on sexual competence of male rats

Effects of Tribulus terrestris saponins on exercise performance in overtraining rats and the underlying mechanisms

Protective Effect of Tribulus terrestris Hydroalcoholic Extract against Cisplatin-Induced Cytotoxicity on Sperm Parameters in Male Mice

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