Definition and current evaluation of subfertile men

Shefi, Shai; Turek, Paul J.

doi:10.1590/s1677-55382006000400002

Cited by 64 publications

(54 citation statements)

References 34 publications

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“…Of this, 2.5% had AZFb deletion and 5% had AZFc deletion and none had AZFa deletion. Our results are in concordance (though slightly lower) with the data published [31], which states that the relative frequency of individual microdeletions are 60%, 5% and 16% for AZFc, AZFa and AZFb regions. Don Kyung Choi et al, [32] observed an association between Y chromosome microdeletions and birth rates with multiple TESE.…”

Section: Discussionsupporting

confidence: 92%

Yq MICRODELETIONS IN IDIOPATHIC MALE INFERTILITY

Kumar¹,

Mishra²,

Dada³

2017

IJAR

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Introduction: Male infertility contributes to nearly 30% of the total infertile population worldwide. Genetic factors contribute to about 15% of the causes of male infertility. Systematically elucidating the underlying genetic causes (chromosomal and Yq microdeletion) may help to reduce the number of men with idiopathic infertility and provide them with the most suitable therapeutics and counseling.

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Section: Discussionsupporting

confidence: 92%

Yq MICRODELETIONS IN IDIOPATHIC MALE INFERTILITY

Kumar¹,

Mishra²,

Dada³

2017

IJAR

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“…Infertility affects about 15% of couples trying to conceive and the male factor contributes to about half of these cases (Shefi & Turek 2006). In fact, male infertility is a problem that is growing steadily, so that currently about 8% of men at reproductive age seek medical help (Miyaoka & Esteves 2012).…”

Section: Introductionmentioning

confidence: 99%

“…In fact, male infertility is a problem that is growing steadily, so that currently about 8% of men at reproductive age seek medical help (Miyaoka & Esteves 2012). In this context, varicocele plays an important role as it is the most common cause of male infertility, affecting from 15 to 20% of healthy adults and adolescents worldwide (Jarow et al 1996, Shefi & Turek 2006, Agarwal et al 2012, prevailing in 35% of cases of male primary infertility and in 80% of cases of secondary male infertility (Jarow et al 1996). Studies have already suggested that it disturbs from 25 to 40% of the semen analyses (Dohle et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Resveratrol improves reproductive parameters of adult rats varicocelized in peripuberty

Mendes¹,

Paccola²,

Neves³

et al. 2016

Reproduction

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The aim of this study was to investigate the protective action of resveratrol against the reproductive damage caused by left-sided experimental varicocele. There was a reduction of testicular major axis in the varicocele group when compared with the other groups; the testicular volume was reduced in varicocele group in comparison to the sham-control and resveratrol groups. The frequency of morphologically abnormal sperm was higher in varicocele and varicocele treated with resveratrol groups than in sham-control and resveratrol groups. The frequency of sperm with 100% of mitochondrial activity and normal acrosome integrity were lower in varicocele group than in varicocele treated with resveratrol, sham-control and resveratrol groups. Sperm motility was also reduced in varicocele group than in other groups. The sperm DNA fragmentation was higher in varicocele group than in other groups.

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“…The most common Y-chromosome deletion in infertile men is the one affecting the DAZ gene (deleted in azoospermia) located in AZFc region. The relative frequency of individual microdeletions are 60%, 5% and 16% for AZFc, AZFa and AZFb regions, but combined deletions occur in about 15% of the cases [15]. Since deletions tend to occur between large palindromic repeats, Repping et al (2002) proposed a more appropriate nomenclature using the name of the flanking repeats for the types of recurrent deletions [13] (Fig.…”

Section: Genetic Testing For Y-chromosome Infertilitymentioning

confidence: 99%

“…Abnormalities in the male genome characterized by damaged sperm DNA may be indicative of male subfertility regardless of routine semen parameters which do not reveal DNA defects. An abnormal proportion of spermatozoa with fragmented DNA can be found in 5% of infertile men with normal semen analyses and 25% of infertile men with abnormal semen analyses but is rarely seen in fertile men [15]. Advanced paternal age, inadequate diet intake, drug abuse, pesticide environmental exposure, tobacco use, varicocele, medical disease, hyperthermia, air pollution, genital inflammation or infectious diseases can be cited as possible causes, some of which are reversible.…”

Section: Sperm Dna Integrity Assaysmentioning

confidence: 99%

What is New in the Clinical Assessment and Treatment of the Infertile Male

Esteves¹

2011

TORSJ

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Male infertility is a fast-evolving area. Recently published evidence has challenged several established concepts and added to the knowledge in the field. Traditionally, the clinical assessment of the subfertile male includes a history and physical examination, hormonal evaluation and semen analyses. Regarding the latter, the World Health Organization has established new reference values that in general include lower limits than those of previous editions. Specialized sperm function assays, such as sperm DNA integrity and measurements of oxidative stress, are now clinically available and may be integrated to the conventional semen analysis to provide a more comprehensive evaluation of a man's fertility status. Also, molecular biology genetic testing involving the Y-chromosome can correctly identify oligozoospermic and azoospermic men misdiagnosed as having idiopathic infertility and be of prognostic value for sperm retrieval in non-obstructive azoospermia. In the field of treatment, emerging evidence suggests that antioxidant therapy along with life-style modifications improve the male reproductive health. Microsurgery has increased the success rates for both varicocele treatment and sperm retrieval for assisted conception. Microsurgical treatment of clinical varicoceles may optimize reproductive outcome of couples undergoing intracytoplasmic sperm injection or microsurgical testicular sperm extraction. Men with non-obstructive azoospermia, elevated follicle-stimulating hormone levels and small testes may no longer be considered sterile. Modern retrieval techniques are used to collect testicular sperm that can be used to produce a healthy biological offspring via assisted conception. This article reviews what is new in the clinical assessment and treatment of the infertile male, including the implications of this increased knowledge in the management of the infertile couple and assisted reproduction technology outcomes.

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Definition and current evaluation of subfertile men

Cited by 64 publications

References 34 publications

Yq MICRODELETIONS IN IDIOPATHIC MALE INFERTILITY

Yq MICRODELETIONS IN IDIOPATHIC MALE INFERTILITY

Resveratrol improves reproductive parameters of adult rats varicocelized in peripuberty

What is New in the Clinical Assessment and Treatment of the Infertile Male

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