Coexistence of prostate neoplasia in patients undergoing radical cystoprostatectomy due to vesical neoplasia

Romero, Frederico R.; Castro, Marí­lia Germanos de; Júnior, Adalberto Andriolo; Meneses, Alex H. de; Fernandes, Roni C.; Perez, Marcelo Vaz

doi:10.1590/s1677-55382004000400005

Cited by 11 publications

(7 citation statements)

References 13 publications

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“…As the depth of biopsy is limited, the tissue taken is usually from bladder transitional epithelial mucosa above the tumor mass. Therefore, it is sometimes hard in these cases to obtain an accurate diagnosis by biopsy of a mass of prostatic origin, especially when the patient has inflammation, atypical hyperplasia or in situ carcinoma of the bladder trigone [9,10]. …”

Section: Discussionmentioning

confidence: 99%

A retrospective study of prostate cancer cases mimicking urothelial cell carcinoma of the bladder

Liu

Xie

2013

Eur J Med Res

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BackgroundProstate cancer (PCa) originating from the prostate base may intrude into the urinary bladder and may be misdiagnosed as bladder cancer. In this retrospective study, we reviewed the clinic data on PCa cases which were initially misdiagnosed as bladder cancer in order to identify diagnostic methods that would allow a better differential diagnosis for PCa.MethodsOut of a total of 455 patients treated for PCa at our hospital between April 2003 and June 2011, 14 patients (3.1%) had been initially misdiagnosed as urinary bladder urothelial cell carcinoma. The clinical data on these 14 cases was retrieved and analyzed.ResultsOf the 14 patients, 11 patients were eventually diagnosed with PCa after MRI examination, and seven out of these had PCa with bladder neck invasion. Prostate needle biopsy or transurethral resection of prostate (TURP) revealed that all 14 patients had adenocarcinoma of prostate with Gleason scores ranging from 7 to 9. Nine patients received TURP for hematuria or lower urinary tract blockage. The mean follow-up was 37 months, during which six patients survived.ConclusionsAs clinical presentation and in emergency settings, prostate cancer originating from the prostate base can be confused with bladder cancer originating from the neck or the triangle region of the urinary bladder. Serum prostate specific antigen (PSA) levels and digital rectal examination, in combination with transrectal ultrasound (TRUS), MRI, and prostate needle biopsy are valuable tools for definitive differential diagnosis of the basal prostate cancer.

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Section: Discussionmentioning

confidence: 99%

A retrospective study of prostate cancer cases mimicking urothelial cell carcinoma of the bladder

Liu

Xie

2013

Eur J Med Res

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“…Incidental PCa is a common finding in RCP specimens in developed countries, according to a series of reports [16][17][18][19][20][21][22][23]. However, no studies have compared the prevalence of incidental PCa in RCP specimens in Asia with that in Western countries.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of incidental prostate cancer in patients undergoing radical cystoprostatectomy: data from China and other Asian countries

Zhu¹,

Ye²,

Yao³

et al. 2008

Asian J Androl

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The purpose of this study is to investigate the frequency of prostate cancer (Pca) discovered incidentally in radical cystoprostatectomy specimens in Asia and to determine the feasibility of prostate-sparing cystectomy (PSC) for Asian patients. Ninety-two male bladder cancer patients who underwent radical cystoprostatectomy at our center between January 2003 and January 2008 were included in this study. The mean age of patients was 67.1 years (range: 32-75 years). Prostate-specific antigen (PSA) levels and digital rectal examination (DRE) results before surgery were obtained retrospectively. Prostates of all patients were embedded and sectioned at 5-mm intervals. The same pathologist examined the prostatic tissues from radical cystoprostatectomy specimens. Finally, a structured literature review was performed using MEDLINE and PUBMED to estimate the occurrence of incidental Pca in Asia. Of the 92 patients, 3 (3.3%) were found to have Pca; in one out of three (33.3%) patients the disease was clinically significant due to a Gleason grade 4 carcinoma. Eight articles were included in our review. The overall incidence of Pca discovered incidentally in radical cystoprostatectomy specimens in Asia was 9.9% (64/642). When age was restricted to < 60 years, only 7 out of 222 (3.2%) patients were found to have synchronous Pca, and none of the cases was clinically significant. The occurrence of Pca in radical cystoprostatectomy specimens in Asia is much lower than that in Western countries. PSC might be feasible for Asian patients under a strict preoperative selection.

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“…The prostate adenocarcinoma has a relatively high incidence (22-55%; in our series 21.6%) in cystoprostatectomy specimens [2,[11][12][13][14][15][16][17][18][19] . Most of these tumors are clinically ignorable.…”

Section: Discussionmentioning

confidence: 99%

Should Prostate Cancer Status Be Determined in Patients Undergoing Radical Cystoprostatectomy?

Şanlı¹,

Acar²,

Celtik³

et al. 2006

Urol Int

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Introduction: We estimate the frequency of prostate cancers detected incidentally in radical cystoprostatectomy specimens and discuss whether the prostate cancer status should be determined in patients undergoing radical cystoprostatectomy. Materials and Methods: A total of 97 radical cystoprostatectomies without evidence of prostate cancer on digital rectal examination were performed for transitional cell carcinomas of the bladder between January 2001 and May 2004. The mean patient age at the time of surgery was 66.9 ± 9.52 (range 49–75) years. Results: The overall incidence of prostate cancer detected in radical cystoprostatectomy specimens was 21.6% (21/97 specimens). The mean tumor volume was found to be 0.93 ± 0.81 ml. The tumor volume was >0.5 ml in 12 cases (57.1%). The surgical margin was negative in all cases, and the disease was organ confined in 20 patients (95.2%). Capsular invasion was evident in 2 patients (9.5%), 1 of whom had lymph-node-positive disease. Conclusions: Despite the high prevalence of incidental prostate carcinomas among patients with bladder cancer undergoing cystoprostatectomy, the vast majority of the cancers are organ confined. However, the prostate cancer status should be determined on the basis of digital rectal examination and prostate-specific antigen in patients undergoing radical cystoprostatectomy – especially if prostate-sparing cystectomy is planned.

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Coexistence of prostate neoplasia in patients undergoing radical cystoprostatectomy due to vesical neoplasia

Cited by 11 publications

References 13 publications

A retrospective study of prostate cancer cases mimicking urothelial cell carcinoma of the bladder

A retrospective study of prostate cancer cases mimicking urothelial cell carcinoma of the bladder

Prevalence of incidental prostate cancer in patients undergoing radical cystoprostatectomy: data from China and other Asian countries

Should Prostate Cancer Status Be Determined in Patients Undergoing Radical Cystoprostatectomy?

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