Low serum vitamin D is associated with an increased likelihood of acquired premature ejaculation

Abstract

Purpose:To investigate the relationship between 25-hydroxyvitamin D (25 (OH) D) levels and acquired premature ejaculation (PE).Materials and Methods:A total of 97 patients with acquired PE and 64 healthy men as a control group selected from volunteers without PE attending our Andrology Outpatient Clinic between November 2016 and April 2017 were included the study. All patients were considered to have acquired PE if they fulfilled the criteria of the second Ad Hoc International Society for Sexual Medicine Committee. Premature ejaculation diagnostic tool questionnaires were used to assessment of PE and all participants were instructed to record intravaginal ejaculatory latency time. Vitamin D levels were evaluated in all participants using high performance liquid chromatography method included in the study.Results:Compared to men without PE, the patients with acquired PE had significantly lower 25 (OH) D levels (12.0 ± 4.5 ng/mL vs. 18.2 ± 7.4 ng/mL, p < 0.001). In the logistic regression analysis, 25 (OH) D was found to be an independent risk factor for acquired PE, with estimated odds ratios (95% CI) of 0.639 (0.460-0.887, p = 0.007) and the area under curve of the ROC curve of 25 (OH) D diagnosing acquired PE was 0.770 (95% CI: 0.695 to 0.844, p < 0.001). The best cut-off value was 16 ng/mL with a sensitivity of 60.9%, specificity of 83.5%, PPV of 70.9%, and NPV of 76.4% to indicate acquired PE.Conclusions:This study demonstrates that lower vitamin D levels are associated with the acquired PE. The result of our study showed that the role of serum vitamin D levels should be investigate in the etiology of acquired PE. Perhaps supplementation of vitamin D in men with acquired PE will ameliorate the sexual health of these patients.

Premature Ejaculation and Endocrine Disorders: A Literature Review

“…In logistic regression analysis, vitamin D was determined to be an important risk factor for LPE (p<0.001). Canat et al [ 92 ] investigated the relationship between vitamin D levels and APE, and determined the vitamin D level in the APE group as 12.0±4.5 ng/mL and in the control group as 18.2±7.4 ng/mL. They suggested that serum vitamin D levels should be investigated in the etiology of APE, although the sensitivity and specificity are relatively low in the relationship between vitamin D deficiency and APE (60.9% and 83.5%, respectively).…”

Association between serum vitamin D levels and acquired premature ejaculation

“…The vit D cut-off level for aPE patients was 16 ng/mL, with a sensitivity of 60.9% and specificity of 83.5%. As a result, they supported that low serum vit D may be an underlying etiological factor for acquired PE [26]. Another study, which included 40 patients with lifelong PE and 40 healthy men, reported that serum vit D levels might be a potential risk factor for PE.…”