“…There are multiple interventions to try to fulfill this objective, such as topic chemotherapy with imiquimod and 5-fluorouracil, laser with carbon dioxide or neodymium: yttrium-aluminum-garnet (Nd: YAG), glans resurfacing excision with circumcision laser, glansectomy with reconstruction, radiotherapy, partial amputation with reconstruction, radical penectomy with perineal urethrostomy, neoadjuvant or adjuvant therapy with surgery, among other interventions (14,15). Also, there are different interventions for managing the inguinal region with the potential to limit morbidities, such as the dynamic sentinel node excision and the video endoscopic inguinal lym-ph node dissection (VEIL) (16,17). T1 low-grade patients could be treated with a conservative approach; otherwise, higher T or high-grade stages will require more extensive procedures (1, 2, 18).…”