Incidence and treatment of malignant tumors of the genitourinary tract in renal transplant recipients

Abstract

Purpose:To provide data of the incidence and management of common urological malignancies in renal transplant recipients.Materials and Methods:We conducted a retrospective analysis of a prospective database from August 1967 to August 2015. A descriptive analysis of the sample was performed.Results:Among 1256 consecutive RTR a total of 88 patients developed malignancies (7%). There were 18 genitourinary tumors in the 16 patients (20.45 % of all malignant neoplasms), incidence of 1.27%. The most common neoplasm encounter was renal cancer (38.8%), followed by urothelial carcinoma (33.3%). Median follow-up of transplantation was 197 months (R, 36-336). Mean time from RT to cancer diagnosis 89±70 months (R, 12-276). CsA and AZA was the most common immunosuppression regimen in 68.75%. Mean follow-up after diagnosis was 103±72 months (R 10-215). Recurrence free survival rate of 100%. Overall survival of 89.5% of the sample; there were two non-related cancer deaths during follow-up.Conclusions:The incidence of neoplasms in RTR was lower than in other series, with favorable functional and oncologic results after treatment. This suggests that actions to reduce the risk of these malignancies as well as a strict follow-up are mandatory for an early detection and treatment.

De-Novo Genitourinary Neoplasms in Transplant Recipients: The Present and Future

“…This lower risk may be due to the www.tridhascholars.org | June-2020 12 intensive screening patients undergo prior to being eligible to list for renal transplant. This is in contrast to multiple smaller series looking at the transplant population around the world that have not only noted similar trends with increased incidence [13,14] and higher proportion of genitourinary tumors (20%-23%) [15,16] but have also noted higher SIR for prostate cancer [14,17,18]. This may be a reflection of different study era as well as varying screening practices for prostate cancer.…”

Urothelial carcinoma arising from the transplanted kidney: A single‐center experience and literature review

“…As it could be seen in Table 1 Whilst UCs in many instances these are fatal, with metastatic disease the usual presentation, complete resolution has been reported with removal of the graft and cessation of immunosuppression. 37 Small RCC in this setting can be managed with parenchymal-sparing approaches including partial nephrectomy and ablative treatments such as cryotherapy and radiofrequency ablation. In a case presented with lung metastases, spontaneous disappearance of the nodules followed the nephroureterectomy of the transplanted graft.…”

“…15 Upper tract UC in our cases and the majority of previously reported cases would thus appear to have developed subsequent to renal transplantation. 37 Prior risk exposure by donors potentially contributed.…”

Re: Incidence and treatment of malignant tumors of the genitourinary tract in renal transplant recipients

“…We read with interest the recent paper by Ochoa - López et al examining the incidence of genitourinary malignancies in renal transplant patients (1). An impressive retrospective analysis of 1256 patients over 48 years is described with a cumulative incidence of 7% for all malignancies identified.…”

“…Specific to genitourinary neoplasia 16 transplant recipients developed malignancies with 18 separate tumours noted in total. Renal cell carcinoma accounted for 7 with 3 tumours developing in the graft and urothelial carcinoma noted in 6 patients (1). Only 2 developed prostate carcinoma.…”