2017
DOI: 10.1590/s1677-5538.ibju.2016.0638
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Abstract: Aim:URS is a very commonly used procedure for treatment of ureter stones. Increased hydrostatic pressure in the collecting system linked to fluids used during the procedure may cause harmful effects on the kidney. The aim of this study is to determine whether the URS procedure has a negative effect on the kidney by investigating NGAL, KIM-1, FABP and Cys C levels in urine.Material and Methods:This study included 30 patients undergoing ureterorenoscopy (URS) for ureter stones. Urine samples were collected 5 tim… Show more

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Cited by 16 publications
(19 citation statements)
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“…The primary end point of the study was to compare the changes of NGAL levels and sample size calculation was performed according to this parameter. In the previous studies NGAL levels showed an increase of 50% for PNL cases 6 and 30% for ureterorenoscopy [5] postoperatively. Sample size calculation revealed that 28 patients were needed for each group to determine a difference of 20% increase in NGAL levels with an alpha value of 0.05 and power level of 80%.…”
Section: Sample Size Calculationmentioning
confidence: 71%
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“…The primary end point of the study was to compare the changes of NGAL levels and sample size calculation was performed according to this parameter. In the previous studies NGAL levels showed an increase of 50% for PNL cases 6 and 30% for ureterorenoscopy [5] postoperatively. Sample size calculation revealed that 28 patients were needed for each group to determine a difference of 20% increase in NGAL levels with an alpha value of 0.05 and power level of 80%.…”
Section: Sample Size Calculationmentioning
confidence: 71%
“…AKI develops following stone surgery and NGAL has been shown to be a good marker for detection of the level of AKI [5,6,9]. Renal parenchymal injury mainly causes the elevation of NGAL in the PNL cases and increased intrarenal pressure is blamed for AKI in RIRS cases [5,6]. In a recent study, Daggulli et al evaluated the changes in NGAL levels in PNL cases and reported a doubled NGAL/creatinine ratio in the postoperative measurement.…”
Section: Discussionmentioning
confidence: 99%
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“…In the present study, we have identified specific kidney and potential infection biomarkers that may provide clinically important information that will aid monitoring and subsequent managing of these patients. Cystatin C is a cysteine proteinase inhibitor which is produced by all nucleated cells and is has gathered increasing interest as a specific marker of kidney function [ 2 ].…”
Section: Introductionmentioning
confidence: 99%
“…Several studies have suggested NGAL may be a useful kidney injury biomarker, particularly in patients with nephrolithiasis or its associated pathologies [ 7 10 ]. NGAL has been reported as a potential renal injury biomarker in the early period after surgery and has a multifaceted role in inflammation and cancer [ 2 , 11 ]. Notably, in their study of urinary biomarkers in 30 patients post-FURS, Benli et al (2017) reported a significant increase in NGAL levels 2 h post-operatively [ 2 ].…”
Section: Introductionmentioning
confidence: 99%