White blood cell counts and neutrophil to lymphocyte ratio in the diagnosis of testicular cancer: a simple secondary serum tumor marker

Abstract

Purpose The aim of the study was to investigate white blood cell counts and neutrophil to lymphocyte ratio (NLR) as markers of systemic inflammation in the diagnosis of localized testicular cancer as a malignancy with initially low volume.Materials and Methods Thirty-six patients with localized testicular cancer with a mean age of 34.22±14.89 years and 36 healthy controls with a mean age of 26.67±2.89 years were enrolled in the study. White blood cell counts and NLR were calculated from complete blood cell counts.Results White blood cell counts and NLR were statistically significantly higher in patients with testicular cancer compared with the control group (p<0.0001 for all).Conclusions Both white blood cell counts and NLR can be used as a simple test in the diagnosis of testicular cancer besides the well-known accurate serum tumor markers as AFP (alpha fetoprotein), hCG (human chorionic gonadotropin) and LDH (lactate dehydrogenase).

Platelet‐to‐lymphocyte ratio predicts the prognosis of patients with non‐small cell lung cancer treated with surgery and postoperative adjuvant chemotherapy

“…Several studies have also shown that low lymphocyte counts are significantly associated with poor survival in lung cancer patients 19, 20. Therefore, peripheral blood lymphocyte counts have been used as an important constituent marker not only in PLR but also in numerous prognostic indicators, such as NLR and the prognostic nutritional index 6, 7, 8…”

“…This is the first study to report that PLR is a more useful prognostic indicator for NSCLC patients treated with surgery and adjuvant chemotherapy compared to all surgical patients. Biomarkers of inflammation, such as NLR or PLR, have been associated with the prognosis of patients with various cancers 7,8 and have specifically been shown to be predictive markers of postoperative prognosis in gastric cancer, 14 cholangiocarcinoma, 15 hepatocellular carcinoma, 8 and primary lung cancer. 16 Some studies have reported that hostderived inflammation, immune response, and coagulation status play important roles in tumor growth, invasion, angiogenesis, and metastasis.…”

“…Numerous factors, such as tumor biomarkers or preoperative comorbidities, have been reported to be prognostic predictors of various cancers. 3,4 In recent years, indicators such as the Glasgow prognostic score, 5 prognostic nutritional index, 6 neutrophil-to-lymphocyte ratio (NLR), 7 and platelet-to-lymphocyte ratio (PLR), 8 which reflect preoperative nutritional status, tumor immunity, potential cancer infiltration, and chronic inflammatory conditions, have been reported to be prognostic factors for several cancers. Measurement of these indicators in patient blood is technically simple, low cost, and does not require specialized facilities.…”

RE: White blood cell counts and neutrophil to lymphocyte ratio in the diagnosis of testicular cancer: a simple secondary serum tumor marker

“…We read the article by Yuksel et al (1) entitled “White blood cell counts and neutrophil to lymphocyte ratio in the diagnosis of testicular cancer: a simple secondary serum tumor marker” published in your journal. This is a very interesting study which is very well-designed and presented.…”

“…Routine peripheral blood counts may be beneficial in prognosis and diagnosis of many disorders, involving testicular cancer (1, 6–13). NLR is measured by dividing the number of neutrophils by the number of lymphocytes.…”